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Application of insulin growth factor acceptor inhibitor PQ401 in as medicine for treating echinococcosis granulosa

A growth factor receptor and cystic echinococcosis technology, which can be used in drug combinations, anti-infective drugs, and pharmaceutical formulations, and can solve problems such as drug resistance of Echinococcus granulosus

Active Publication Date: 2014-12-17
THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In addition, animal experiments and clinical case reports have shown that long-term use of albendazole can lead to drug resistance in Echinococcus granulosus

Method used

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  • Application of insulin growth factor acceptor inhibitor PQ401 in as medicine for treating echinococcosis granulosa
  • Application of insulin growth factor acceptor inhibitor PQ401 in as medicine for treating echinococcosis granulosa
  • Application of insulin growth factor acceptor inhibitor PQ401 in as medicine for treating echinococcosis granulosa

Examples

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Embodiment 1

[0029] Example 1, the application of the insulin-like growth factor receptor inhibitor PQ401 as a drug for the treatment of cystic echinococcosis.

[0030] The insulin-type growth factor receptor inhibitor PQ401 is used as a drug for the preparation of cystic echinococcosis, and its application test is as follows:

[0031] 1. In vitro experiment of insulin-like growth factor receptor inhibitor PQ401 (insulin-like growth factor receptor inhibitor PQ401 referred to as PQ401)

[0032] 1.1 In vitro experiment of PQ401

[0033] 1.1.1 Purpose of the experiment: To explore the effect of PQ401 on the mortality of Echinococcus granulosus cysts in vitro at different concentrations with a period of 2 days.

[0034] 1.1.2 Experimental grouping (overview):

[0035] This experiment is divided into 7 groups, namely PQ401 intervention group 1, PQ401 intervention group 2, PQ401 intervention group 3, PQ401 intervention group 4, PQ401 intervention group 5, negative group and DMSO group; The ...

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Abstract

The invention relates to the technical filed of an insulin growth factor acceptor inhibitor PQ401, and concretely relates to an application of the insulin growth factor acceptor inhibitor PQ401 as a medicine for treating echinococcosis granulosa. The insulin growth factor acceptor inhibitor PQ401 is a novel echinococcosis resistance medicine; in vivo and in vitro pharmacodynamic experiment data show that the PQ401 is an efficient echinococcosis resistance medicine molecule, can destroy the tissue structure of the Echinococcus granulosus vesicles and causes necrosis of a large amount of cells of the Echinococcus granulosus vesicles; in vivo pharmacodynamic experiment data show that the medicine has same echinococcosis granulose treatmetn effect with clinically commonly used albendazole; and the long term administration of albendazole by clinic echinococcosis granulosa patients causes medicine resistance, so the medicine can substitute albendazole to be used in the treatment of the echinococcosis granulosa.

Description

technical field [0001] The invention relates to the technical field of insulin-like growth factor receptor inhibitor PQ401, and relates to the application of the insulin-like growth factor receptor inhibitor PQ401 as a medicine for treating cystic echinococcosis. Background technique [0002] Cystic echinococcosis is a serious hazard, and there is a lack of effective drugs for clinical treatment [0003] Echinococcus (Echinococcus) is a serious zoonotic parasitic disease caused by parasitic larvae of Echinococcus granulosus (Echinococcus granulosus, Eg) in 95% of cases. Cystic echinococcosis (Cystis Echinococcosis, CE) caused by parasitism in the human body. The disease is distributed globally, and the seven provinces in western my country (Xinjiang, Qinghai, Ningxia, Gansu, Tibet, Sichuan, and Inner Mongolia) are high-endemic areas, with a threatened population of 66 million and an annual economic loss of more than 3 billion yuan. One of the main reasons for herdsmen to "f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4706A61P33/02
Inventor 温浩吕国栋林仁勇王建华李娟赵军肖云峰高慧静刘辉王俊华张传山李亮毕晓娟
Owner THE FIRST TEACHING HOSPITAL OF XINJIANG MEDICAL UNIVERCITY
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