Method for measuring TSNAs (tobacco-specific nitrosamines) in electronic cigarette smoke

A measurement method and technology of electronic cigarettes, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of few reports on measurement methods, and achieve the effects of simple pre-treatment, improved analysis throughput, and accurate analysis results

Active Publication Date: 2014-12-24
CHINA TOBACCO YUNNAN IND
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  • Description
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Problems solved by technology

Therefore, the detection of TSNAs content in electronic cigarette smoke is of great signific

Method used

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  • Method for measuring TSNAs (tobacco-specific nitrosamines) in electronic cigarette smoke
  • Method for measuring TSNAs (tobacco-specific nitrosamines) in electronic cigarette smoke
  • Method for measuring TSNAs (tobacco-specific nitrosamines) in electronic cigarette smoke

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[0031] Example 1:

[0032] A liquid chromatography tandem mass spectrometry method for the determination of tobacco peculiar nitrosamines in electronic cigarette smoke. The test process is that the electronic cigarette smoke sample is diluted and directly introduced into a high performance liquid chromatography-triple quadrupole tandem mass spectrometry system for analysis.

[0033] This method is the determination of four specific nitrosamines: NNK, NNN, NAT and NAB, and includes the following steps:

[0034] a. Cigarette smoking: e-cigarette samples are smoked in Canada deep smoking, Massachusetts or ISO smoking mode;

[0035] b. Smoke capture: Use full smoke traps in series with absorption bottles or Cambridge filters, or Cambridge filters in series with absorption bottles, or use Cambridge filters or absorption bottles alone for e-cigarette smoke collection.

[0036] c. Configure standard series solutions: prepare series standard solutions with NNK, NNN, NAT and NAB standard substan...

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Abstract

The invention relates to a high performance liquid chromatography-tandem mass spectrometry method for measuring TSNAs (tobacco-specific nitrosamines) in electronic cigarette smoke, which belongs to the technical field of physical and chemical inspection of an electronic cigarette. The method is characterized by comprising the steps: sucking an electronic cigarette sample by virtue of a smoking machine, trapping the electronic cigarette smoke by adopting a full-smoke trapping device, adopting a Cambridge filter to be serially connected with an absorption bottle, independently adopting the Cambridge filter or independently adopting the absorption bottle, measuring the smoke by adopting a high efficiency liquid phase chromatography-triple quadrupole tandem mass spectrograph, and quantifying analyte by adopting an internal standard method. The method is a brand new method for measuring the content of TSNAs in the electronic cigarette smoke. The method is good in selectivity and accuracy.

Description

technical field [0001] The invention provides a method for measuring TSNAs in electronic cigarette smoke, and relates to the technical field of physical and chemical inspection of electronic cigarettes. Background technique [0002] Electronic cigarettes are officially defined by the World Health Organization as electronic nicotine delivery systems (ENDS). The smoking method and other aspects are relatively close to traditional cigarettes, and are favored by consumers. In the face of various electronic cigarettes on the market, there have been reports that they have potential safety hazards, and some countries have also begun to supervise and conduct related research on them. 4-(nitrosomethylamino)-1-β-pyridyl)-1-butanone (NNK), N-nitrosonornicotine (NNN), N-nitrosoanatabine (NAT) and N-Nitrososine (NAB) is a carcinogen widely present in cigarette smoke, and these substances only exist in tobacco products or cigarette smoke, so they are called tobacco-specific nitrosamines...

Claims

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Application Information

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IPC IPC(8): G01N30/88
Inventor 赵伟张凤梅吴亿勤杨柳尚善斋雷萍段沅杏杨继韩敬美汤建国朱东来陈永宽缪明明
Owner CHINA TOBACCO YUNNAN IND
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