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Preparation method of ox-gall powder

A technology of ox gall powder and ox gall, which is applied in the field of biomedicine, can solve the problems of active ingredient loss, low content, and many impurities, and achieve the effect of less impurities

Inactive Publication Date: 2015-01-07
ANHUI KEBAO BIOLOGICAL ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology involves making an oily substance called bile grease that contains small amounts of various chemicals used for medical purposes like medicine or food products. By removing unwanted materials from this oil through heating under specific conditions, these harmful compounds can be reduced without affecting their quality.

Problems solved by technology

Invention describes how cow's biles can help treat diseases such as laminitis by reducing their symptoms without losing any beneficial chemical compounds that they contain. However current methods involve collecting them from animals themselves which may lead to decomposition and lose some nutrients due to environmental factors like humidity during storage. Therefore an improved way of producing ox biliary powders would provide more effective treatment options while minimizing these drawbacks associated with existing processes involving collection and purification steps.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] In a small laboratory test, weigh 1.5Kg of ox gall paste, add 0.45Kg of sodium hydroxide and 9Kg of purified water, hydrolyze at a temperature of 98°C, hydrolyze for 4 hours, let it stand for cooling and separate layers, take the lower sediment and add purified water to the original volume, Add 0.3kg of 30% hydrogen peroxide several times in small amounts, and the oxidation time is 10 hours. After the oxidation is completed, filter with 0.8μm and 1.2μm filter membranes, filter to obtain the supernatant, and input it into the spray dryer for drying. The air temperature is 120°C, the outlet air temperature is 60°C, the evaporation water is 10L / h, and the maximum feeding amount is 20L / h. After drying, 0.975kg of ox gall powder is obtained, with a yield of 65%. The content is 41.5% by UV-Vis spectrophotometry. %.

Embodiment 2

[0016] In the pilot test in the workshop, weigh 15Kg of ox gall paste, add 4.5Kg of sodium hydroxide and 90Kg of purified water, hydrolyze at 100°C, hydrolyze for 6 hours, let stand for cooling and separate layers, take the lower layer of sediment and add purified water to the original volume, a small amount and more Add 6kg of 30% hydrogen peroxide every time, and the oxidation time is 10h. After the oxidation is completed, filter with 0.8μm and 1.2μm filter membranes, filter to obtain the supernatant, and input it into the spray dryer for drying, and set the inlet air temperature 135°C, air outlet temperature 70°C, evaporation water volume 80L / h, maximum feeding volume 100L / h, after drying, 9.5kg of ox gall powder was obtained, with a yield of 63.3%, and a content of 43.3% determined by UV-Vis spectrophotometry.

Embodiment 3

[0018] In large-scale production in the workshop, weigh 200Kg plus 100Kg of sodium hydroxide and 1600Kg of purified water, hydrolyze at a temperature of 102°C, hydrolyze for 8 hours, let stand for cooling and stratify, take the lower layer of sediment and add purified water to the original volume, and add 80kg30 for several times % hydrogen peroxide, the oxidation time is 12h, after the oxidation is completed, filter with 0.8μm and 1.2μm filter membranes, filter to obtain the supernatant, input it into the spray dryer for drying, set the air inlet temperature to 150°C, and the air outlet The temperature is 80°C, the evaporation water is 120L / h, and the maximum feeding amount is 150L / h. After drying, 139.5kg of ox gall powder is obtained, with a yield of 69.75%. The content is 44.7% as determined by UV-Vis spectrophotometry.

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Abstract

The invention discloses a preparation method of ox-gall powder. The ox-gall powder is prepared according to the following steps of: hydrolyzing ox-gall cream by adding sodium hydroxide of which the weight is 0.3-0.5 fold of that of the ox-gall cream and purified water of which the weight is 6-8 folds of that of the ox-gall cream for 4-8 hours at the temperature of 98-102 DEG C; keeping stand, and cooling and layering; adding purified water into the bottom-layer sediment obtained after hydrolysis until the volume reaches the original volume, and oxidizing the bottom-layer sediment with 30 percent hydrogen peroxide of which the weight is 0.2-0.4 fold of that of the ox-gall cream for 10-12 hours; filtering by using microfiltration membranes with the apertures of 0.8 and 1.2 microns to obtain supernate; feeding the supernate in to a spray dryer for drying to obtain the ox-gall powder after drying is finished. The preparation method has the advantages that impurities are less (many impurities exist in the traditional method because of no impurity removal through oxidation); the content of cholic acid is between 40 and 45 percent (the content of cholic acid in the traditional method is between 20 and 35 percent); the yield is up to 60-70 percent (the yield in the traditional method is 40-55 percent); the product is powder of which the color is from faint yellow to yellow (the conventional product is powder of which the color is from yellowish-brown to tawny).

Description

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Claims

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Application Information

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Owner ANHUI KEBAO BIOLOGICAL ENG CO LTD
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