A kind of processing method of traditional Chinese medicine toad venom
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A processing method, the technology of toad venom, applied in the direction of amphibian medical raw materials, etc., can solve the problem of low content of bufadienolactones
Active Publication Date: 2019-08-23
许翔鸿
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[0017] Aiming at the low content of bufadiene lactones commonly found in toad venom medicinal materials, the invention discloses a method for treating toad venom medicinal materials or to-be-processed toad venom raw materials with water or an acidic aqueous solution. The method can significantly increase the concentration of bufadiene lactones The content of bufadienolactones can solve the problem that the content of bufadienolactones in Bufadienolactones is generally low
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Embodiment 1
[0060] Pulverize the toad venom medicinal material, take 50g of toad venom powder, add 400ml of 0.5% hydrochloric acid aqueous solution (pH value is 0.9) to soak, shake well, let it stand for layering, discard the upper liquid; add 200ml of the above-mentioned 0.5% hydrochloric acid aqueous solution to soak, shake well , place to make layers, discard the upper liquid; add 200ml of water, shake well, let stand to make layers, discard the upper liquid, and repeat again; keep the lower layer of solid, after drying at 60 ℃, it is the processed toad's venom.
Embodiment 2
[0062] Crush the toad venom medicinal material, take 50g of toad venom powder, add 400ml of 1% acetic acid aqueous solution (pH value is 2.8) to soak, shake well, place to separate layers, discard the upper liquid; add 200ml of the above 1% acetic acid aqueous solution to soak, shake well, and place Make layers, discard the upper liquid; add 200ml of water, shake well, let stand to make layers, discard the upper liquid, and repeat again; keep the lower solid, dry at 60°C, it is the processed toad's venom.
Embodiment 3
[0064] Pulverize the toad venom medicinal material, take 50g of toad venom powder, add 400ml of 0.2% acetic acid + 0.1% hydrochloric acid aqueous solution (pH value is 1.6) to soak, shake well, place to separate layers, discard the upper liquid; add 200ml of the above acidic aqueous solution to soak, Shake well, let it stand for stratification, discard the upper liquid; add 200ml of water, shake well, let it stand for stratification, discard the upper liquid, and repeat again; keep the lower solid, dry it at 60°C, and it will be the processed toad’s venom .
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Abstract
The invention discloses a treatment method for processing traditional Chinese medicine venenum bufonis. The treatment method comprises the following steps: adopting water or an acidic aqueous solution to perform extracting treatment on venenum bufonis or a raw material to be processed of venenum bufonis; selecting the solid layer, and drying to obtain the processed venenum bufonis. The treatment method can remarkably improve the contents of the bufadienolide compositions which are the medicinal effective components in venenum bufonis; as numerous venenum bufonis products in the traditional Chinese medicine product market are discrepant to the standard of the contents of the bufadienolide compositions specified by Chinese pharmacopoeia, by adopting the treatment method to process venenum bufonis, the qualification rate of the index of the contents of the bufadienolide compositions specified by Chinese pharmacopoeia can be greatly improved.
Description
technical field [0001] The invention belongs to the field of traditional Chinese medicine processing, and specifically relates to a processing method capable of significantly improving the quality of traditional Chinese medicine toad venom. Background technique [0002] Bufonis Venenum (Bufonis Venenum) was first recorded in the already lost Tang Dynasty Materia Medica "On the Properties of Medicine", and its original name was Bufonis Venenum. It has the functions of relieving pain, resuscitating the mind, detoxifying and reducing swelling, etc., and is widely used clinically. It is the dry secretion of Bufo bufo gargarizans Cantor or Bufo melanositictus Schneider (Chinese Pharmacopoeia Part I 2010). [0003] Ming Li Shizhen's "Compendium of Materia Medica" records the traditional harvesting and processing methods: "Take toad cakes in different ways, or pinch the eyebrows with your hands, take white juice on oil paper, and mulberry leaves, and put them in the shade of the b...
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