Noninvasive human liver cancer early detection and differential diagnosis method and system

A technology for early detection and differential diagnosis, applied in the field of clinical medicine, can solve the problems of imaging examinations that cannot be used for early diagnosis, serological tests lack specificity, and cannot be used for early diagnosis.
CN104313136AInactive Publication Date: 2015-01-28YIKONGENOMICS
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
YIKONGENOMICS
Publication Date
2015-01-28
Estimated Expiration
Not applicable Β· inactive patent

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Abstract

The invention discloses a noninvasive human liver cancer early detection and differential diagnosis method which comprises the following steps: 1) extracting free DNA of plasma from in-vitro plasma, and constructing a genomic sequencing library; 2) sequencing the DNA, measuring the DNA sequence of the genome, and performing sequence alignment; 3) by taking different genome sequence lengths as basic analysis units, performing chromosome copy number variation CNV analysis, and constructing chromosome CNV graphs to observe whether visual observable copy number variation exists; and 4) by taking the different genome sequence lengths as basic analysis units, performing Z-score analysis of chromosome copy number variation CNV. The detection method disclosed by the invention can be used for early detection and differential diagnosis of liver cancer and is used for preclinical study or clinical detection.
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Description

technical field

[0001] The invention relates to a molecular detection method for realizing non-invasive early detection and differential diagnosis of liver cancer by detecting isolated blood, and belongs to the field of clinical medicine. Background technique

[0002] Liver cancer is the fifth most common cancer and the second most common cause of cancer death in the world. The survival rate of small liver cancer after surgery can reach more than 80%, but most patients are diagnosed at an advanced stage, and the survival rate is often less than 6 months. Therefore, timely and accurate diagnosis of liver cancer is the primary task to improve the survival rate of liver cancer patients. Because liver cancer often occurs on the basis of chronic hepatitis cirrhosis, it is generally not easy to distinguish early. Therefore, traditional detection methods have many defects in the early detection, differential diagnosis and early treatment of liver cancer, especially the inability to...

Claims

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