Application of microRNA (ribonucleic acid) has-miR939 in hypertension diagnosis

A has-mir939, tiny nucleotide technology, applied in the application field of the tiny nucleotide has-miR939 in the diagnosis of hypertension, can solve problems such as family and national burden, consumption of medical and social resources, and disability

Active Publication Date: 2015-02-18
YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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Problems solved by technology

[0004] Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases. Its major complications such as stroke, myocardial infarction, heart failure and chronic kidney disease not only cause disability and high mortality rate, but also seriously consume medical and social resources. heavy burden on the state

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  • Application of microRNA (ribonucleic acid) has-miR939 in hypertension diagnosis
  • Application of microRNA (ribonucleic acid) has-miR939 in hypertension diagnosis
  • Application of microRNA (ribonucleic acid) has-miR939 in hypertension diagnosis

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Embodiment 1

[0018] In this embodiment, the present invention mainly discusses and clarifies the differentially expressed miRs in the process of prehypertension and hypertension through the research method of miR expression profile chip. This study revealed for the first time the expression changes of miRs related to prehypertension and hypertension, which not only helps to more comprehensively elucidate the molecular mechanism of hypertension, but also provides a series of new molecular markers for the evaluation of hypertension disease progression , and provided a series of new miR-based therapeutic targets, which laid a good foundation for the research and development of miR-based treatments for lowering blood pressure and protecting target organs in hypertension.

[0019] 1. Method

[0020] 1. Sample collection for clinical research

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Abstract

The invention relates to an application of microRNA (ribonucleic acid) has-miR939 in hypertension diagnosis. The application has the advantages as follows: plasma of hypertension patients in prehypertension and normal people is collected for research on whole-genome miR expression profile, research results show that a series of miRs are related to prehypertension and hypertension, and differentially expressed miRs help to explain the molecular mechanism for hypertension incidence; a molecular marker is provided for progress evaluation of prehypertension and hypertension; a brand new therapeutic target is provided for effective blood pressure control and treatment of prehypertension and hypertension; and meanwhile, an antagonist and a mimic containing a single miR or combining multiple miRs are adopted, and a brand new means is provided for treatment of prehypertension and hypertension.

Description

[0001] This application is a divisional application with an application date of November 26, 2013, application number 201310605650.4, and an invention titled "Application of Micronucleotides in the Diagnosis of Hypertension and Preparation of Antihypertensive Drugs". technical field [0002] The present invention relates to a new application of micro nucleotides, specifically, the application of micro nucleotide (microRNA) has-miR939 in the diagnosis of hypertension. Background technique [0003] Hypertension (hypertension) is a common chronic disease characterized by persistently elevated arterial blood pressure, which refers to arterial systolic blood pressure ≥ 140 mmHg and / or diastolic blood pressure ≥ 90 mmHg in a resting state. A systolic blood pressure of 120-139 mmHg and / or a diastolic blood pressure of 80-89 mmHg is called prehypertension or high normal. [0004] Hypertension is the most important risk factor for cardiovascular and cerebrovascular diseases. Its majo...

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6883C12Q2600/136C12Q2600/158C12Q2600/178
Inventor 张腾陈瑜贾成林杨琴波王培伟李黎崔金刚杜宵烨宁冰冰刘丽
Owner YUEYANG INTEGRATED TRADITIONAL CHINESE & WESTERN MEDICINE HOSPITAL SHANGHAI UNIV OF CHINESE TRADITIONAL MEDICINE
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