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Medicine combination with antibacterial and synergically-antibacterial effects, and preparation method and application

An antibacterial effect and drug technology, applied in the field of drug research and development, can solve the problems of no antibacterial and synergistic antibacterial drug substance combinations, no research reports on the treatment of infectious diseases, etc., to improve sensitivity, prolong survival time, and reduce death rate effect

Active Publication Date: 2015-02-25
石任兵 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no relevant reports on the purification and preparation of antibacterial and synergistic antibacterial drug substance combinations from Perilla Prescription, and there are no relevant research reports on the composition in the treatment of infectious diseases

Method used

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  • Medicine combination with antibacterial and synergically-antibacterial effects, and preparation method and application
  • Medicine combination with antibacterial and synergically-antibacterial effects, and preparation method and application
  • Medicine combination with antibacterial and synergically-antibacterial effects, and preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0098] Embodiment 1: antibacterial traditional Chinese medicine drug substance combination preparation process

[0099] Perilla seed 133.3g Perilla stem 133.3g Salvia 333.3g

[0100] Sophora flavescens 200g Scutellaria baicalensis 200g

[0101] According to the above ratio, take 1 kg of the raw material drug decoction pieces, extract 2 times with 10 times the amount of 50% ethanol under reflux, and extract for 2 hours each time, combine the two extracts (total 20L) and concentrate under reduced pressure until the relative density is 1.15-1.20g / ml Add water to disperse the clear paste, so that the concentration of the sample solution is 0.05g / mL (in terms of the amount of raw medicinal materials, the total phenol concentration is 3.1493mg / ml, the total alkaloid concentration is 0.4504mg / ml, and the baicalin concentration is 1.3042 mg / ml, the concentration of salvianolic acid B is 1.0660mg / ml, the concentration of rosmarinic acid is 0.0790mg / ml, the concentration of tanshinone ...

Embodiment 2

[0122] Perilla seed 133.3g Perilla stem 133.3g Salvia 333.3g

[0123] Sophora flavescens 200g Scutellaria baicalensis 200g

[0124] Take 1 kg of raw drug decoction pieces according to the above ratio, extract once with 5 times the amount of 50% ethanol under reflux, and extract for 1 hour each time, combine the two extracts (total 20L) and concentrate under reduced pressure until the relative density is 1.15-1.20g / ml Add water to disperse the clear paste, so that the concentration of the sample solution is 0.05g / mL (in terms of the amount of raw medicinal materials, the total phenol concentration is 3.1493mg / ml, the total alkaloid concentration is 0.4504mg / ml, and the baicalin concentration is 1.3042 mg / ml, the concentration of salvianolic acid B is 1.0660mg / ml, the concentration of rosmarinic acid is 0.0790mg / ml, the concentration of tanshinone II A is 0.0296mg / ml), and the sample solution is adsorbed through 3L AB-8 type macroporous The resin is dynamically adsorbed, the ad...

Embodiment 3

[0145] Perilla seed 133.3g Perilla stem 133.3g Salvia 333.3g

[0146] Sophora flavescens 200g Scutellaria baicalensis 200g

[0147] According to the above ratio, take 1 kg of the raw material drug decoction pieces, extract 2 times with 10 times the amount of 50% ethanol under reflux, and extract for 2 hours each time, combine the two extracts (total 20L) and concentrate under reduced pressure until the relative density is 1.15-1.20g / ml Add water to disperse the clear paste, so that the concentration of the sample solution is 0.05g / mL (in terms of the amount of raw medicinal materials, the total phenol concentration is 3.1493mg / ml, the total alkaloid concentration is 0.4504mg / ml, and the baicalin concentration is 1.3042 mg / ml, the concentration of salvianolic acid B is 1.0660mg / ml, the concentration of rosmarinic acid is 0.0790mg / ml, the concentration of tanshinone II A is 0.0296mg / ml), and the sample solution is adsorbed through 3L AB-8 type macroporous The resin is dynamical...

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Abstract

The invention discloses a medicine combination with antibacterial and synergically-antibacterial effects. The traditional Chinese medicine combination is obtained by performing ethanol extraction, macroporous adsorption resin purifying on a perilla frutescens prescription, phenols, alkaloids and diterpenoid quinones compositions in the perilla frutescens prescription are enriched, also in-vitro and in-vivo antibacterial experiments prove that the medicine combination has obvious in-vitro bacteriostatic effect, and the medicine combination is capable of improving sensitivity of pathogen on antibiotics and has synergic antibacterial effect by being combined with a cephalo-type antibiotic for usage. Prophylactic medicine usage is capable of reducing the mortality of a generally-infected model mouse, prolonging the survival time and improving the life quality. The medicine combination shows relatively strong antibacterial activity both in vivo and in vitro.

Description

technical field [0001] The invention belongs to the field of drug research and development, and relates to a combination of Chinese medicine substances, in particular to a combination of Chinese medicine substances with antibacterial and synergistic antibacterial effects, and a method for simultaneously preparing the combination. Background technique [0002] Bacterial infection poses a huge threat to human health. With the long-term, large-scale, and irrational use of antibiotics, the problem of bacterial resistance is becoming more and more serious, which not only causes adverse reactions, drug-induced diseases and even death in patients, but also the possibility of superinfection It has increased greatly, and has increased the economic burden of the patient's family, and has also caused a serious waste of national medical and health resources. Traditional Chinese medicine is a unique natural resource in our country. Many single Chinese medicines have been confirmed to hav...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539A61P31/04A61P29/00A61P11/10A61P11/14
CPCA61K9/0019A61K9/0053A61K9/08A61K9/143A61K9/2031A61K9/2059A61K36/489A61K36/535A61K36/537A61K36/539A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2300/00
Inventor 石任兵王永炎安琪彭平姜艳艳唐雪阳卢广英温静朱乃亮王春梅张硕峰
Owner 石任兵
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