A kind of enrofloxacin microcapsule for injection and preparation method thereof
A technology for enrofloxacin and injection, which is applied in the field of traditional Chinese veterinary medicine, can solve the problems of animal refusal to eat, poor palatability, and bitterness of enrofloxacin, and achieve the effects of low cost, increased palatability, and simple preparation process
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Embodiment 1
[0017] An enrofloxacin microcapsule for injection, consisting of enrofloxacin and auxiliary materials, is characterized in that: it consists of the following raw materials in parts by weight: 0.5-2 parts of enrofloxacin, 6-8 parts of gum arabic, carboxylated 1-2 parts of sodium methylcellulose, 0.5-2 parts of emulsifier, 0.5-2 parts of anti-sticking agent, 17-80 parts of solvent, 2.5-8 parts of antioxidant.
[0018] The emulsifier is composed of the following raw materials by weight: 1-1.5 parts of lipophilic emulsifier, and 0.5-2 parts of hydrophilic emulsifier;
[0019] The lipophilic emulsifier is at least one of Span, cholesterol and soybean lecithin;
[0020] The hydrophilic emulsifier is at least one of Tween, glycerin, poloxamer and polyethylene glycol-6000.
[0021] Described antisticking agent is a kind of in talcum powder, silica gel and stearate;
[0022] The solvent is at least one of propylene glycol, polyethylene glycol-4000, glycerol formal and dimethylformami...
Embodiment 2
[0028] An enrofloxacin microcapsule for injection, consisting of enrofloxacin and auxiliary materials, is characterized in that: it is composed of the following raw materials in parts by weight: 50g of enrofloxacin, 600g of gum arabic, and 100g of sodium carboxymethylcellulose , emulsifier 50g, talcum powder 50g, propylene glycol 1700g, sodium formaldehyde sulfoxylate 250g.
[0029] The emulsifier is composed of the following crude drugs in parts by weight: Span-20100g as the lipophilic emulsifier, and Tween-2050g as the hydrophilic emulsifier.
[0030] The specific steps are:
[0031] Weigh Arabic gum and sodium carboxymethyl cellulose, dissolve in water, add enrofloxacin and emulsifier, and stir with a homogenizer to obtain an emulsion; then add anti-tack agent talcum powder to the emulsion, stir to make it disperse evenly, and carry out Spray drying to obtain white powdery microcapsules; mix the microcapsules with the prepared solvent propylene glycol, add the antioxidant ...
Embodiment 3
[0034] An enrofloxacin microcapsule for injection, consisting of enrofloxacin and auxiliary materials, is characterized in that: it consists of the following raw materials in parts by weight: 60g of enrofloxacin, 610g of gum arabic, and 105g of sodium carboxymethylcellulose , emulsifier 60g, silica gel 60g, polyethylene glycol-40002200g, sodium metabisulfite 300g.
[0035] The emulsifier is composed of the following raw materials in parts by weight: the lipophilic emulsifier is 105 g of cholesterol, and the hydrophilic emulsifier is 60 g of glycerin.
[0036] The specific steps are:
[0037] Weigh Arabic gum and sodium carboxymethylcellulose, dissolve in water, add enrofloxacin and emulsifier, and stir with a homogenizer to obtain an emulsion; then add anti-sticking agent silica gel to the emulsion, stir to disperse evenly, and spray Dry to obtain white powdery microcapsules; mix the microcapsules with the prepared solvent polyethylene glycol 4000, add antioxidant sodium meta...
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