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A kind of preparation method and product of hydroxyapatite/graphene nanocomposite powder

A technology of hydroxyapatite and nanocomposite, which is applied in dental preparations, pharmaceutical formulations, medical science, etc., and can solve the problems of rod-shaped hydroxyapatite size and shape, which limit the application of nanocomposites, and harsh preparation conditions. , achieve excellent mechanical properties and biocompatibility, improve mechanical and biological properties, controllable particle size and shape

Active Publication Date: 2016-06-29
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The hydrothermal method provided in this patent document prepares graphene / hydroxyapatite nanocomposite materials, the preparation conditions are harsh, the equipment requirements are high, and the energy consumption is also high; The size and shape are not adjustable, which greatly limits the application of the nanocomposite

Method used

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  • A kind of preparation method and product of hydroxyapatite/graphene nanocomposite powder
  • A kind of preparation method and product of hydroxyapatite/graphene nanocomposite powder
  • A kind of preparation method and product of hydroxyapatite/graphene nanocomposite powder

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] (1) Weigh the redox graphene powder according to the mass of graphene accounting for 1% of the mass of the final theoretically produced hydroxyapatite powder, and ultrasonicate it in deionized water for 120 hours in a water bath ultrasonic environment.

[0052] (2) Add calcium nitrate to the graphene solution to form Ca 2+ Calcium nitrate / graphene mixed solution with a concentration of 2.5mol / L, and an aqueous solution of diammonium hydrogen phosphate with a concentration of 1.5mol / L.

[0053] (3) Add ammonia water to the mixed solution of calcium nitrate and graphene to adjust the pH value to 11, then stir and drop the diammonium hydrogen phosphate aqueous solution, and at the same time use the method of stirring and dropping ammonia water to adjust the pH value of the mixed solution to 11, During this process, the dropping speed was 5ml / min, the stirring speed was 200 rpm, and the stirring was continued for 2 hours after the dropwise addition was completed to obtain a...

Embodiment 2

[0059] (1) Weigh the redox graphene powder according to the mass of graphene accounting for 0.1% of the mass of the final theoretically generated hydroxyapatite powder, and ultrasonicate it in deionized water for 120 hours in a water bath ultrasonic environment.

[0060] (2) Add calcium nitrate to the graphene solution to form Ca 2+ Calcium nitrate / graphene mixed solution with a concentration of 2.5mol / L, and an aqueous solution of diammonium hydrogen phosphate with a concentration of 1.5mol / L.

[0061] (3) Add ammonia water to the mixed solution of calcium nitrate and graphene to adjust the pH value to 11, then stir and drop the diammonium hydrogen phosphate aqueous solution, and at the same time use the method of stirring and dropping ammonia water to adjust the pH value of the mixed solution to 11, In this process, the dropping speed is 5ml / min, and the stirring speed is 200 rev / min, and the stirring is continued for 2 hours after the dropwise addition is completed, and the...

Embodiment 3

[0065] (1) Weigh the redox graphene powder according to the mass of graphene accounting for 1% of the mass of the final theoretically produced hydroxyapatite powder, and ultrasonicate it in deionized water for 120 hours in a water bath ultrasonic environment.

[0066] (2) Add calcium nitrate to the graphene solution to form Ca 2+ A calcium nitrate / graphene mixed solution with a concentration of 0.5mol / L, and an aqueous solution of diammonium hydrogen phosphate with a concentration of 0.3mol / L.

[0067] (3) Add ammonia water to the mixed solution of calcium nitrate and graphene to adjust the pH value to 12, then stir and drop diammonium hydrogen phosphate aqueous solution, and at the same time use the method of stirring and dropping ammonia water to adjust the pH value of the mixed solution to 12, During this process, the dropping speed was 5ml / min, the stirring speed was 300 rpm, and the stirring was continued for 3 hours after the dropping was completed, to obtain a hydroxyap...

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Abstract

The invention discloses a preparation method of hydroxyapatite / graphene nano-composite powder. The preparation method comprises the following steps: ultrasonically dispersing graphene into ionized water, so as to obtain graphene dispersion liquid; adding calcium nitrate into graphene dispersion liquid, uniformly mixing to obtain a mixed solution, firstly dropwise adding ammonia water into the mixed solution to regulate the pH value to 11-14, stirring, dropwise adding a diammonium hydrogen phosphate solution so that calcium nitrate completely reacts, simultaneously dropwise adding ammonia water to keep the pH value constant, after dropwise adding, carrying out continuous stirring and curing, and carrying out filtering, washing, drying and grinding to obtain the hydroxyapatite / graphene nano-composite powder. The preparation method is mild in reaction condition, simple, easy to control, low in facility request and convenient for industrial production. According to the prepared hydroxyapatite / graphene nano-composite powder, the particle size and the shape of hydroxyapatite which coats the surface of graphene are controllable, and graphene is well combined with hydroxyapatite, so that the dynamical and biological properties of hydroxyapatite can be effectively improved.

Description

technical field [0001] The invention relates to the field of preparation of nanocomposite materials, in particular to a method for preparing hydroxyapatite / graphene nanocomposite powder and its products. Background technique [0002] Biomedical materials are a class of high-tech materials developed in the past 30 years, which are used for diagnosis, treatment, or replacement of human tissues and organs or their functions. With the advancement of social civilization, economic development, and increasing living standards, human beings also attach great importance to their own medical rehabilitation. my country's modern biomedical materials and artificial organ industries are in their infancy, and most of the achievements are still in the laboratory stage. Therefore, the research and development of biomedical materials has great social and economic value. [0003] Hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 , abbreviated as HAP or HA) is an inorganic component of human and anim...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/08A61K6/033A61K6/027A61K6/838
Inventor 刘奕黄晶袁建辉刘玉鑫李华
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI