Unlock instant, AI-driven research and patent intelligence for your innovation.

Dialysis concentrate for supplementing nickel elements

A concentrate and nickel element technology, which is applied in the direction of drug combination, medical preparations containing active ingredients, active ingredients of alkali/alkaline earth metal chlorides, etc., can solve the problems of component concentration gradient difference and loss, and achieve the reduction of nickel element Loss, reduce the burden of metabolism, improve the effect of comfort

Inactive Publication Date: 2015-03-25
TIANJIN SHENYOUDA MEDICAL EQUIP TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, because the components of the human blood inside the dialyzer membrane and the dialysate outside the membrane are different, the components in the human blood will be partially lost due to the concentration gradient difference

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Dialysis concentrate for supplementing nickel elements
  • Dialysis concentrate for supplementing nickel elements
  • Dialysis concentrate for supplementing nickel elements

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0028] Blood side: 5L of 706 generation plasma, added NiCl 2 ·6H 2 O0.53mg (ie Ni 2+ The ion concentration is 0.44μmol / L);

[0029] Dialysate side: the formula of the dialysis concentrate is selected from the formula described in Example 1 in Table 3, and after dilution according to A:B:water=1:1.6:32.4, the ion concentration in the dialysate is as shown in Table 4:

[0030] Table 4: After the dialysis concentrate was diluted in Experimental Example 1, the ion concentration and pH value in the dialysate

[0031] ion

Na +

K +

Ca 2+

Mg 2+

Cl -

HCO 3 -

Ni 2+

pH

concentration

138mmol / L

2.0mmol / L

1.5mmol / L

0.5mmol / L

114mmol / L

27.36mmol / L

0.44μmol / L

7.0-8.0

[0032] After the simulated dialysis experiment example 1 was completed, the content of nickel element in the 706 generation plasma and dialysate was detected by atomic absorption method, as shown in Table 5.

[0033] Table 5: ...

experiment example 2

[0036] Blood side: 5L of 706 generation plasma, added NiCl 2 ·6H 2 O0.53mg (ie Ni 2+ The ion concentration is 0.44μmol / L);

[0037] Dialysate side: the formula of the dialysis concentrate is selected from the formula described in Example 2 in Table 3, and after dilution according to A:B:water=1:1.6:32.4, the ion concentration of the dialysate is as shown in Table 6:

[0038] Table 6: After the dialysis concentrate was diluted in Experimental Example 2, the ion concentration and pH value in the dialysate

[0039] ion

Na +

K +

Ca 2+

Mg 2+

Cl -

HCO 3 -

Ni 2+

pH

concentration

138mmol / L

2.0mmol / L

1.5mmol / L

0.5mmol / L

114mmol / L

27.36mmol / L

0.22μmol / l

7.0-8.0

[0040] After the simulated dialysis experiment example 2 was completed, the content of nickel element in the 706 generation plasma and dialysate was detected by atomic absorption method, as shown in Table 7.

[0041] Table 7: ...

experiment example 3

[0044] Blood side: 5L of 706 generation plasma, added NiCl 2 ·6H 2 O0.53mg (ie Ni 2+ The ion concentration is 0.44μmol / L);

[0045] Dialysate side: the formula of the dialysis concentrate is selected from the formula described in Example 3 in Table 3, and after dilution according to A:B:water=1:1.6:32.4, the ion concentration of the dialysate is as shown in Table 8:

[0046] Table 8: After the dialysis concentrate was diluted in Experimental Example 3, the ion concentration and pH value in the dialysate

[0047] ion

Na +

K +

Ca 2+

Mg 2+

Cl -

HCO 3 -

Ni 2+

pH

concentration

138mmol / L

2.0mmol / L

1.5mmol / L

0.5mmol / L

114mmol / L

27.36mmol / L

0.11μmol / l

7.0-8.0

[0048] After the simulated dialysis experiment example 3 was completed, the content of nickel element in the 706 generation plasma and dialysate was detected by atomic absorption method, as shown in Table 9.

[0049] Table 9: ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention provides a dialysis concentrate for supplementing nickel elements, and the dialysis concentrate comprises water soluble nickel chloride, wherein the water soluble nickel chloride comprises NiCl2.6H2O; the water soluble nickel chloride comprises NiCl2.6H2O with concentration of 9.2-36.8 mg / 10L. According to the invention, nickel ions are added in dialyzate to effectively prevent the loss of the nickel ions in a human body and control the nickel ions within a reasonable concentration range of the human body, in order to reduce the metabolism burden of patients and improve the dialysis comfort to ensure the living quality of the patients.

Description

technical field [0001] The invention belongs to the technical field of dialysis concentrates, in particular to a dialysis concentrate supplemented with nickel. Background technique [0002] In the existing technology, the dialysis concentrate is usually composed of A and B components, wherein the A preparation is sodium chloride, potassium chloride, calcium chloride, magnesium chloride, and acid regulators, etc., and the B preparation is bicarbonate Sodium, or add sodium chloride to form. Its form can be dry powder or concentrated solution. When used, the dialysis dry powder needs to be dissolved and diluted into a concentrated solution. The dialysis concentrated solution can be directly connected to a dialysis machine for hemodialysis. [0003] Regardless of the formulations of preparations A and B, and regardless of the dilution ratio of the dialysis machine, the main ion content in the dialysate diluted by the dialysis machine must meet the treatment requirements, that i...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K33/24A61P7/08A61K33/14A61K33/06A61K33/00
CPCA61K33/24A61K33/00A61K33/06A61K33/14A61K2300/00
Inventor 李波曹慕真李杰刘娟琴
Owner TIANJIN SHENYOUDA MEDICAL EQUIP TECH