65 results about "Dialyzates" patented technology

The invention provides synthesis of a T-2 toxin antigen and preparation and application of a monoclonal antibody. Relates to the technical field of biotoxin detection. The preparation method of the T-2 toxin antigen comprises the following steps: step 1, synthesizing an immunogen T-2-BSA by adopting a carbodiimide method, dissolving 2mg of T-2 adipic acid with 0.5 mL of dimethylformamide, and recording as a solution A; 5 mg of bovine serum albumin and 3 mg of EDC are dissolved with a 2-morpholine ethanesulfonic acid buffer solution with the pH being 5.5, and the solution is marked as a solution B; step 2, under the condition of stirring, dropwise adding the solution A into the solution B, stirring for 18 hours in a dark place at 4 DEG C, then dialyzing for 3 days by using a phosphate buffer solution, changing the solution once a day, centrifuging the dialysate for 10 minutes at 3,500 r / min, and discarding the precipitate; the adipic acid is coupled with the T-2 toxin through a chemical method, and the unique step enriches the structural characteristics of the hapten, so that the prepared T-2 toxin complete antigen is excellent in immune effect, can efficiently excite immune response of an organism, and shows high specificity and sensitivity.

The invention relates to the technical field of solution electrolyte detection, in particular to an on-line real-time quantitative detection method for iCa in laser-induced breakdown spectroscopy dialyzate, which comprises the following steps: obtaining an original spectrum according to a training sample set, preprocessing the original spectrum to obtain a preprocessed spectrum, converting the preprocessed spectrum into a two-dimensional spectrum matrix, and calculating the iCa in the two-dimensional spectrum matrix; carrying out feature extraction to obtain a feature spectrum; the initial model is trained according to the characteristic spectrum and the first training sample set to obtain an optimization model; and establishing a regression curve by the optimization model according to the test sample set, and evaluating the optimization model to obtain a concentration prediction model. According to the invention, the original spectrum is pretreated to obtain the pretreated spectrum, so that the problems of non-uniform distribution of substances in the dialysate and non-uniform excitation degrees of the same sample in an experiment are solved; a concentration prediction model is obtained according to the regression curve, accurate detection of the content of the two elements of ionized calcium or potassium in the real flowing dialysate is achieved according to the concentration prediction model, and clinical requirements are completely met.

The present invention relates to an apparatus and a method for preparing dialyzate, wherein the apparatus has a first part and a second part that is configured as a circuit; wherein the first part comprises a water connection or a water container as well as the primary side of a filter; wherein the filter is configured to prepare purified water from the water through forward osmosis; and wherein the second part comprises the secondary side of the filter, a reservoir, a filtrate line that leads from the secondary side of the filter to the reservoir, and a line leading from the reservoir to the secondary side of the filter, with the reservoir being a container having means for connecting the container to a dialysis machine.

The invention discloses a borneol type cinnamomum burmanni leaf carbon quantum dot as well as a preparation method and application thereof. The preparation method comprises the following steps: cleaning fresh borneol type cinnamomum burmannii leaves, drying and crushing to obtain borneol type cinnamomum burmannii leaf powder, mixing the borneol type cinnamomum burmannii leaf powder with a solvent, and carrying out solvothermal reaction; centrifuging the reaction product, filtering the obtained supernatant with a 0.22 [mu] m filter membrane, dialyzing the obtained filtrate, and drying the dialysate to obtain the borneol type cinnamomum burmanni leaf carbon quantum dots. The preparation method is simple and easy to operate, and large-scale production is realized. The borneol type cinnamomum burmannii leaf carbon quantum dots obtained by the preparation method are excellent in permeation promotion effect and have the effects of resisting inflammation and inhibiting scar hyperplasia.

This invention discloses a production process for a carbon material used to adsorb toxic substances from dialysate, comprising the following steps: S1, crushing fruit shells; S2, mixing the selected fruit shells with a cellulase solution and performing full enzymatic hydrolysis in an enzymatic hydrolysis chamber; S3, mixing the hydrolyzed fruit shells with a phosphoric acid solution and impregnating them in an oven; S4, filtering the impregnated fruit shells and drying them in an oven; S5, placing the dried fruit shells in a tube furnace for carbonization and activation treatment; S6, washing the activated material with clean water and recovering the phosphoric acid; S7, after drying, an adsorbent carbon material with a well-developed meso- and macroporous pore structure and a high specific surface area is obtained. Compared with the prior art, this invention uses an enzymatic hydrolysis method, which allows the activator to fully penetrate into the interior of the fruit shell, causing some biomass components in the fruit shell to dissolve and form channels, facilitating the penetration of the activator solution and improving the adsorption effect of the carbon material.

The invention discloses a processing method for preparing carbon dots from bean clear liquid, the carbon dots and application thereof, and belongs to the technical field of nano materials. The method comprises the following steps: carrying out a hydrothermal reaction on the bean clear liquid, cooling after the hydrothermal reaction is ended, centrifuging the cooled reaction liquid, taking the supernate, filtering, taking the filtrate, dialyzing, and drying the dialysate, so as to obtain the bean clear liquid carbon dots. According to the method, the bean clear liquid is utilized, so that the effect of waste utilization can be achieved, and the environmental pollution can be reduced. The prepared bean supernatant carbon dots are good in dispersity and stability, can penetrate through the blood brain barrier and inhibit Abeta40 aggregation, and are wide in application range and high in additional value.

A hydraulic system and method are provided for breaking-up, dislodging, removing, and preventing the build-up of biofilm in a dialysate pathway of an extracorporeal blood treatment device. The dialysate pathway can include a dialyzer discharge line, a drain line, a dialyzer feed line, and a bypass system. At least one ultrasonic device can be positioned and configured to generate ultrasonic waves in the dialysate pathway and to propagate the ultrasonic waves along at least a portion of the dialysate pathway. The ultrasonic waves can be used to break-up biofilm. An ionizing electrode pair can also, or instead, be implemented to break-up, dislodge, remove, and prevent a build-up of biofilm. The system and method can particularly be implemented and useful in non-disposable portions of a hydraulic system of an extracorporeal blood treatment device.

This invention relates to the field of carbon nanomaterial preparation technology, specifically a high-yield preparation method for carbon quantum dots and its application. The preparation method includes: adding citric acid, ethylenediamine, EDC, and NHS to deionized water, stirring at 60-90°C for a preset time to obtain a mixed solution; subjecting the mixed solution to a hydrothermal reaction, cooling to room temperature after the reaction is complete, and then centrifuging, filtering, and dialyzing; freeze-drying the dialysate to obtain carbon quantum dots. This invention combines EDC and NHS pretreatment with a hydrothermal method to prepare carbon quantum dots. The solvent used is water, which is non-toxic, harmless, safe, and reliable. The process is simple, safe, and environmentally friendly. Simple pretreatment can greatly improve the yield of carbon quantum dots while ensuring quantum efficiency. The preparation equipment is simple, the process is safe, and it consumes fewer resources, which is conducive to large-scale production.

The invention discloses a selenium-rich dendrobium polysaccharide and a preparation method thereof, wherein the preparation method comprises the following steps: 1) taking a dendrobium officinale extract and adding a nitric acid solution to dissolve it; 2) taking the solution obtained in step 1), adding sodium selenite and barium chloride to react for 6 to 10 hours, cooling and filtering, taking the filtrate to adjust the pH value to 4 to 7, dialyzing, taking the dialyzate and drying, and obtaining the selenium-rich dendrobium polysaccharide. The preparation method of the selenium-rich dendrobium polysaccharide of the invention, through specific synthesis process parameters and a concentration and purification method, the total polysaccharide content in the selenium-rich dendrobium polysaccharide is greater than 90%, and the selenium content is greater than 1.2 mg / g. Experiments have proved that it has significant antioxidant and anti-wrinkle activities.

The invention provides a lactobacillus fermentation extraction method of marine red algae polysaccharide and application of the marine red algae polysaccharide, and the method comprises the following steps: mixing marine red algae powder with water, and carrying out pasteurization at 60-70 DEG C for 20-40 minutes; adding lactobacillus plantarum into the sterilized marine red algae turbid liquid, and performing fermentation culture to obtain a marine red algae fermentation mixed liquid; heating and extracting the marine red algae fermentation mixed solution at 85-95 DEG C for 1.5-2.5 hours, centrifuging, collecting supernate, carrying out rotary evaporation and concentration to 1 / 5 of the original volume, then adding ethanol, standing overnight, discarding the supernate, adding distilled water into precipitate for redissolving, and deproteinizing by using a Sevag method to obtain a polysaccharide solution; and dialyzing the polysaccharide solution, and concentrating and freeze-drying the dialysate to obtain the marine red algae polysaccharide. According to the method, the low-molecular-weight modified polysaccharide is obtained through lactobacillus plantarum fermentation, extraction and purification, and the low-molecular-weight modified polysaccharide is high in sulfate group content, loose in structure, capable of remarkably inhibiting AGEs-induced intestinal cell oxidative stress and inflammatory reaction, capable of being used for preparing the glycosylation injury resisting medicine and good in industrialization prospect.

The invention discloses a fenugreek seed extract preparation method, which comprises: taking fenugreek seeds, crushing to obtain a fenugreek seed crushing material, adding ethanol to the fenugreek seed crushing material, and pre-soaking to obtain a first mixture; performing pulsed electric field treatment on the first mixture to obtain a second mixture; the second mixture is put into an extraction tank for extraction, and an extracting solution is obtained; the extracting solution is firstly subjected to microfiltration through a ceramic membrane and then subjected to ultrafiltration through an organic membrane, and dialysate is obtained; concentrating the dialysate through an organic nanofiltration membrane to obtain a concentrated solution; adding gamma-cyclodextrin into the concentrated solution to carry out inclusion treatment, so as to obtain an inclusion solution; and carrying out spray drying treatment on the inclusion liquid to obtain the fenugreek seed extract. According to the method, the production cycle is shortened, the production cost is reduced, the content of 4-hydroxyisoleucine is increased, the stability of 4-hydroxyisoleucine is enhanced, and the redissolved clarity and bitter taste of the extract are improved.

The utility model provides an electromagnetic induction aluminum foil sealing machine for a dialysate packaging bottle, and belongs to the technical field of sealing equipment. Comprising a mounting frame, a sealing device and a conveying belt, the conveying belt is horizontally arranged on the mounting frame, the sealing device is arranged on the mounting frame and located above the conveying belt, the sealing device is in communication connection with a mainframe box, first baffles are arranged on the two sides of the conveying belt correspondingly, and arc-shaped limiting plates are arranged at the feeding end of the conveying belt on the faces, close to each other, of the two first baffles correspondingly; the sides, away from the sealing device, of the limiting plates are arc-shaped inner sides, a conveying opening allowing the packaging bottles to penetrate through is reserved between the two limiting plates, and a sealing groove of the sealing device is located above the conveying opening. A worker only needs to place a packaging bottle at the feeding end of the conveying belt, the packaging bottle can be automatically aligned with the sealing groove after penetrating through the conveying opening, and the effects of reducing the labor intensity and improving the production efficiency are achieved.

The utility model belongs to the technical field of blood purification. The dialyzer shell comprises a first barrel, a second barrel, a dialysate connector, reinforcing ribs and a first boss, the first barrel is arranged at the two ends of the second barrel, the dialysate connector and the first boss are arranged on the outer side of the first barrel, the dialysate connector is perpendicular to the axis of the first barrel, the first boss is arranged in the mode that the first barrel protrudes outwards, and the reinforcing ribs are arranged on the first boss. The first boss is located on the side, close to a port of the first barrel, of the dialysate connector, a plurality of reinforcing ribs are arranged between the dialysate connector and the first barrel, one reinforcing rib is connected with the first boss, and the other reinforcing ribs are connected with the outer wall of the first barrel in an arc mode. The first boss is arranged on the outer side of the first barrel, one reinforcing rib is connected with the first boss, the other reinforcing ribs are connected with the outer wall of the first barrel in an arc mode, sharp points can be eliminated, the wall thickness of the root of the dialysate connector is kept uniform, generation of internal stress is reduced, and therefore the strength of the dialysate connector is enhanced.

A hydraulic system and method are provided for breaking-up, dislodging, removing, and preventing the build-up of biofilm in a dialysate pathway of an extracorporeal blood treatment device. The dialysate pathway can include a dialyzer discharge line, a drain line, a dialyzer feed line, and a bypass system. At least one ultrasonic device can be positioned and configured to generate ultrasonic waves in the dialysate pathway and to propagate the ultrasonic waves along at least a portion of the dialysate pathway. The ultrasonic waves can be used to break-up biofilm. An ionizing electrode pair can also, or instead, be implemented to break-up, dislodge, remove, and prevent a build-up of biofilm. The system and method can particularly be implemented and useful in non-disposable portions of a hydraulic system of an extracorporeal blood treatment device.

The dialysate barrel feeding device comprises a first conveyor and a second conveyor which are sequentially arranged in the dialysate barrel conveying direction, the discharging end of the first conveyor is in butt joint with the feeding end of the second conveyor, and the conveying speed of the first conveyor is smaller than that of the second conveyor; the barrel separating and clamping assembly is located in front of the joint of the first conveyor and the second conveyor and comprises a pair of oppositely-arranged clamping pieces, the clamping pieces are located on the two sides of the first conveyor correspondingly, and the distance between the clamping pieces is smaller than the width of a dialysate barrel; friction force between the first conveyor and the dialysate barrel and friction force between the second conveyor and the dialysate barrel can drive the dialysate barrel to leave the clamping piece; the distance between the contact position of the clamping piece and the dialysate barrel and the joint of the first conveyor and the second conveyor is smaller than the length of the dialysate barrel. The dialysate barrel separating and counting device can accurately and effectively separate and count dialysate barrels.

The invention discloses a preparation method and application of Gd / Ho bimetallic doped carbon dots, and relates to the technical field of nanomaterials, the preparation method comprises the following steps: 1, carrying out ultrasonic treatment on urea, gallic acid, a Ho-containing compound and a Gd-containing compound in deionized water to obtain a mixed emulsion; step 2, adding the mixed emulsion obtained in the step 1 into a microwave oven, and carrying out closed high-temperature reaction to obtain a reaction solution; and step 3, treating the reaction liquid obtained in the step 2 with deionized water, centrifuging, taking supernate, dialyzing in water to obtain dialysate, and freeze-drying the dialysate to obtain the Ho / Gd doped carbon dots. According to the carbon dot synthesized by doping Gd and Ho, the carbon dot has a fluorescence / magnetic resonance / electronic computed tomography three-mode imaging function at the same time, and the three imaging modes have excellent imaging capability, so that the carbon dot is beneficial to the practical application of biological imaging.

The utility model relates to the technical field of dialyzers, in particular to a glue injection cover of a dialyzer. The glue injection cover of the dialyzer comprises a dialysate tube, a glue injection cover body, a hollow fiber membrane and a groove block, the glue injection cover body is clamped on a dialyzer shell, the dialysate tube is connected and communicated with the dialyzer shell, the hollow fiber membrane located in the dialyzer shell is connected to the glue injection cover body, and the groove block is connected to the hollow fiber membrane. A plurality of grooves are evenly formed in the glue injection cover along the circumference, a plurality of groove blocks are further arranged on the glue injection cover, and the groove blocks and the grooves are distributed at intervals. The polyurethane adhesive flows in from the sintering end surface of the hollow fiber membrane and flows along the fiber direction of the hollow fiber membrane, so that the resistance of the polyurethane adhesive in the flowing process is reduced, and the problem of insufficient filling of the polyurethane adhesive is effectively solved.

The utility model relates to a directional feeding device for a dialyzer end cover, a dialysate flow opening of the end cover is of a circumferential protruding structure, the directional feeding device comprises a straight vibration feeding assembly, a static material channel assembly, an end cover transferring mechanism and an end cover directional mechanism, the static material channel assembly is arranged in the conveying direction of the straight vibration feeding assembly, and the end cover directional mechanism is arranged on the end cover transferring mechanism. The end cover transferring mechanism clamps and moves the end cover, and a stop block and a deflector rod in the end cover orientation mechanism are matched to limit the rotation angle of the dialysate flow opening, so that the dialysate flow opening is forcibly corrected to the preset direction. The end cover feeding device solves the problem that in the prior art, when end covers are fed, the directions of dialysate flow openings of the end covers are inconsistent. The device can greatly improve the production efficiency and reduce the time and cost of manual adjustment.

The utility model provides a stacking device for a dialysate thermal shrinkage packaging robot, which can further improve the safety in the dialysate stacking process and ensure that dialysate thermal shrinkage packaging is not scratched or adsorbed to deform, and comprises a transverse moving component, a pressing component and an L-shaped supporting plate, the top of the vertical end of the L-shaped supporting plate is connected with the transverse moving assembly, the downward pressing assembly is assembled on the transverse moving assembly or a fixed assembly of the mechanical arm, the L-shaped supporting plate comprises a vertical fixed frame, a connecting cylinder and deformable comb teeth, and the top of the vertical fixed frame is connected with the transverse moving assembly; the connecting cylinder is a rectangular pipe body, and the bottom of the vertical fixing frame is connected to the top of the connecting cylinder; a rotating shaft is arranged in the connecting cylinder, a rotating motor is arranged at any end of the connecting cylinder, and the rotating motor is connected with the rotating shaft; a plurality of assembly holes are formed in one side of the connecting cylinder; the end of one deformable comb tooth is connected to the position of one assembly hole, and the smooth wedge-shaped tip end of the deformable comb tooth tilts upwards under the action of the rotating motor.

The application provides a preparation method of selenium-doped Prussian blue nanoparticles modified by a targeting polypeptide, and comprises the following steps: (1) synthesizing Prussian blue nanoparticles by a microwave method; (2) synthesizing selenium-containing Prussian blue by a gas-phase atomic deposition method; and (3) preparing selenium-doped Prussian blue nanoparticles modified by a targeting polypeptide: dissolving a tumor-targeting RGD cyclic peptide in ultrapure water, adding a catalyst N-hydroxysuccinimide and 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride and then stirring, then performing dialysis, adding the selenium-containing Prussian blue into the dialysate, stirring, centrifuging, resuspending and obtaining the selenium-doped Prussian blue nanoparticles modified by the targeting polypeptide. According to the preparation method, the selenium is naturally deposited on the surface of the Prussian blue by the gas-phase atomic deposition method, monodisperse selenium with controllable doping amount is formed, and the selenium-doped Prussian blue modified by the targeting polypeptide is prepared.

The application discloses a method for separating different size negatively charged metal oxide nanolayers, which comprises the following steps: preparing a negatively charged inorganic metal oxide material; dialyzing the inorganic metal oxide material with deionized water for 24 hours, and replacing the dialysate every 6 hours to obtain a colloidal suspension; dividing the colloidal suspension into n test groups, adding dilute hydrochloric acid to each group, shaking uniformly, and then standing to form an upper dispersion liquid and a lower precipitate; testing the Zeta potential of the upper dispersion liquid and the lower precipitate respectively, and determining the test group with the maximum Zeta potential difference; collecting the upper dispersion liquid and the lower precipitate of the test group with the maximum Zeta potential difference, centrifuging and washing, and then freeze-drying to obtain metal oxide nanolayers with different sizes. The material obtained by the solution method has a thinner thickness and a larger surface area, can expose rich active sites, and has a wide application prospect in the fields of energy and catalysis.

The present invention relates to a dialysate composition having a composition having a composition allowing for a balance with blood comprising mineral salts and a pH buffer, and comprising at least one iron oxide nanoparticle (Fe2+ and / or Fe3+) coated with at least one polymeric compound.

The utility model relates to the technical field of dialysate preparation, and provides a dialysate preparation device which comprises a cabinet, a display screen and a control switch are arranged on the top of the front wall of the cabinet, an installation groove is formed in the front wall of the cabinet, and a partition plate is fixed in the installation groove; the touch screen is arranged at the top of the cabinet through a lifting mechanism; the dialysate preparation instrument is arranged below the partition plate, and a liquid inlet of the dialysate preparation instrument is fixedly communicated with a liquid inlet pipe; by means of the technical scheme, the problems that in the prior art, when a dialysate preparation device supplements dialysate to different dialysate tank bodies, a connecting pipe needs to be taken down and installed on other dialysate tank bodies, operation is tedious, meanwhile, a touch screen of an existing dialysate preparation device is generally directly exposed in the external environment, and operation is inconvenient are solved. When the device is not used, dust accumulation and accidental touch easily cause failure of the touch screen, and the service life of the device is affected.

The present invention relates to a system for jointly producing erythritol and liquid sorbitol by using a corn starch, including a liquefaction tank, a saccharification tank, a filter and a nanofiltration assembly. The liquefaction tank is used to perform liquefaction for the corn starch, the saccharification tank is used to perform saccharification for the liquefied material, the filter is used to filter out impurities in the saccharified material to obtain a glucose liquid, and the nanofiltration assembly is used to perform nanofiltration for the filtered glucose liquid to respectively obtain a dialysate and a concentrate. The system further includes a fermentation and crystallization assembly for performing fermentation and crystallization for the dialysate to prepare crystalline erythritol, and a hydrogenation and evaporation assembly for performing hydrogenation and evaporation for the concentrate to prepare liquid sorbitol. The present invention further provides a method of jointly producing erythritol and liquid sorbitol by using a corn starch. The present invention not only improves the purity of erythritol but also obtains liquid sorbitol, thus improving the utilization value of the corn starch.

The present invention discloses a preparation method and application of Gd / Ho bimetallic doped carbon dots, relating to the field of nanomaterial technology. The method comprises the following steps: 1. Ultrasonication of urea, gallic acid, a Ho-containing compound, and a Gd-containing compound in deionized water to obtain a mixed emulsion; 2. Adding the mixed emulsion obtained in step 1 to a microwave oven for sealed, high-temperature reaction to obtain a reaction solution; and 3. Treating the reaction solution obtained in step 2 with deionized water, centrifuging it, and dialyzing the supernatant in water to obtain a dialysate. The dialysate is freeze-dried to obtain Ho / Gd-doped carbon dots. The carbon dots synthesized by doping Gd and Ho in the present invention simultaneously possess triple-modal imaging capabilities: fluorescence, magnetic resonance imaging, and computed tomography. All three imaging modalities exhibit excellent imaging capabilities, making them advantageous for practical applications in biological imaging.

The invention relates to the field of iron ion detection, and particularly provides a fluorescent probe for detecting iron ions as well as a preparation method and application of the fluorescent probe. The fluorescent probe is a fluorescent nano material and is prepared by taking alkanet as a carbon source. The method comprises the following steps: S1, pretreating alkanet to obtain dry powder; s2, carrying out pyrolysis on the dried powder; s3, performing ultrasonic extraction and centrifugation; s4, carrying out filtration and dialysis; and S5, freeze-drying the obtained dialysate to obtain the fluorescent probe. The powdery fluorescent probe is dissolved in water and mixed with a solution to be detected, the fluorescence emission spectrum of the mixed solution is detected, and iron ions in the solution are detected through the change of fluorescence intensity. Fluorescent carbon dots are prepared based on pyrolysis of alkanet, a conjugated structure is reserved, chemical modification is not needed, the fluorescent carbon dots are green, low in toxicity and uniform in particle size, carboxyl / hydroxyl and other functional groups are contained on the surface, the fluorescent carbon dots can be coordinated with Fe < 3 + >, and high-sensitivity selective detection is achieved.

The invention discloses selenium-enriched spirulina carbon dots as well as a preparation method and application thereof, and belongs to the technical field of medicines. The selenium-rich spirulina powder is obtained by taking selenium-rich spirulina growing to a logarithmic phase as a raw material, centrifuging, collecting and freeze-drying. Uniformly mixing the spirulina platensis with a catalyst and deionized water according to a mass ratio of 1: (0.1-0.8): 20, then putting the mixture into a high-temperature reaction kettle to react at 140-260 DEG C for 1.5-5.5 hours, dialyzing the reaction liquid for 24 hours after the reaction is finished, centrifuging, and freeze-drying the dialysate to obtain the selenium-enriched spirulina platensis carbon dots with the yield of 70-95%. The selenium-enriched spirulina carbon dots provided by the invention not only have the inhibition capability of alpha-amylase, alpha-glucosidase, cholesterol esterase and pancreatic lipase and the cholate binding capability, but also can improve the endogenous antioxidant defense capability of model organisms while removing exogenous oxidizing substances, so that the glycolipid metabolism balance is efficiently regulated and controlled.