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Preparation method of p-amino benzamide glutamic acid

A technology of aminobenzoyl glutamic acid and nitrobenzoyl glutamic acid, which is applied in the field of preparation of p-aminobenzoyl glutamic acid, can solve the problems of environmental pollution, seriousness, and low reaction conversion rate, and achieve The effect of reducing environmental pollution and improving the reaction conversion rate

Inactive Publication Date: 2015-04-01
CHANGSHU HUAGANG PHARMA
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Problems solved by technology

[0002] At present, the preparation process of p-aminobenzoyl glutamic acid has low reaction conversion rate and serious environmental pollution

Method used

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Embodiment Construction

[0009] The specific implementation of the present invention will be further described below in conjunction with the examples. The following examples are only used to illustrate the technical solution of the present invention more clearly, but not to limit the protection scope of the present invention.

[0010] The technical scheme of concrete implementation of the present invention is:

[0011] A preparation method for p-aminobenzoyl glutamic acid, comprising the steps of:

[0012] 1) 180g / ml of glutamic acid and p-nitrobenzoyl chloride condensate is dropped into an aqueous solution, stirred until fully dissolved, and made into an aqueous solution of 35% p-nitrobenzoylglutamic acid in a weight ratio;

[0013] 2) Adjust the pH value to 7.3, put in 52g / ml ammonium chloride, heat up to 55°C, add 63g / ml gray cast iron powder, heat up to 75°C, pre-etch for 2.5 hours, heat up to 85°C, and keep warm for 3.5 hours;

[0014] 3) Remove iron sludge by filtration, wash with distilled wa...

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Abstract

The invention discloses a preparation method of p-amino benzamide glutamic acid. The preparation method comprises the following steps of (1) adding 180g / ml glutamic acid and a paranitrobenzoyl chloride condensate into a water solution, and stirring until the 180g / ml glutamic acid and the paranitrobenzoyl chloride condensate are sufficiently dissolved to prepare a p-amino benzamide glutamic acid water solution with the weight ratio of 35%; (2) regulating the pH value to 7.3, adding 52g / ml ammonium chloride, heating to 55 DEG C, adding 63g / ml gray cast iron powder, heating to 75 DEG C, pre-corroding for 2.5 hours, heating to 85 DEG C, and preserving the heat for 3.5 hours; and (3) filtering to remove iron mud, washing with distilled water, adding carbon for discoloring, crystallizing, carrying out suction filtration, washing, and drying to obtain a finished product of p-amino benzamide glutamic acid. By using the preparation method of p-amino benzamide glutamic acid, disclosed by the invention, the reaction conversion rate is increased, and the environment pollution is reduced.

Description

technical field [0001] The invention relates to a preparation method of p-aminobenzoyl glutamic acid. Background technique [0002] At present, in the preparation process of p-aminobenzoyl glutamic acid, the reaction conversion rate is low, and the environmental pollution is relatively serious. Contents of the invention [0003] The object of the present invention is to provide a kind of preparation method of p-aminobenzoyl glutamic acid, improve reaction conversion rate, reduce environmental pollution. [0004] In order to achieve the above object, technical scheme of the present invention is to design a kind of preparation method of p-aminobenzoyl glutamic acid, comprising the steps: [0005] 1) 180g / ml of glutamic acid and p-nitrobenzoyl chloride condensate is dropped into an aqueous solution, stirred until fully dissolved, and made into an aqueous solution of 35% p-nitrobenzoylglutamic acid in a weight ratio; [0006] 2) Adjust the pH value to 7.3, put in 52g / ml ammo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/12C07C237/36
Inventor 徐敬国赵建锋
Owner CHANGSHU HUAGANG PHARMA
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