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Mixed blood component storage bag and method of manufacturing same

A technology for storing bags and polymers, applied in the field of manufacturing such bags, can solve problems such as excessive carbon dioxide permeability and carbon dioxide escape

Active Publication Date: 2018-01-12
TERUMO BCT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, although the BHC plasticizer container has sufficient oxygen permeability, the carbon dioxide permeability may allow too much carbon dioxide to escape
Therefore, the permeability to carbon dioxide may be too large for optimal storage

Method used

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  • Mixed blood component storage bag and method of manufacturing same
  • Mixed blood component storage bag and method of manufacturing same
  • Mixed blood component storage bag and method of manufacturing same

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0046] In the following example, the performance of an embodiment of the hybrid bag 120 will be described in detail for comparison with a bag formed from PVC with the same plasticizer for the entire bag.

[0047] The following example shows five day storage of platelets forming intermediate platelet units (IPU) isolated from whole blood. The IPU is stored for 5 days at a temperature between about 20°C and about 24°C under standard blood bank conditions.

[0048] In the example, IPUs were pooled (3 to 10 IPUs per pool) and distributed into 4 different types of test bags as described below. The target plasma content is 45 to 55ml per IPU. In cases where the volume of the pool is too small to end up with the target plasma content, blood type-matched or ABO-matched plasma is added to bring the volume into the target range. When dispensing the pooled platelets into the bags, all available air was removed so that no air was present in any of the test bags. The conditions provided...

example 2

[0065] A hybrid bag was tested by storing platelets for five (5) days. The hybrid bag is made of PVC using two different plasticizers. One side of the bag is made of PVC with a citrate-based plasticizer. The other side of the bag is also made of PVC, but instead uses TOTM as a plasticizer.

[0066] The research content includes three branches (Arms), and each branch tests different volumes. The table below briefly describes the conditions and results for the three arms of the study.

[0067] Table 2

[0068]

[0069]

[0070] The table below briefly illustrates the number of IPUs for each branch of the study.

[0071] table 3

[0072]

[0073] The structure of the above study shows that a wide range of platelet volume / concentration combinations are well stored in citrate / TOTM bags until day 5.

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Abstract

A hybrid blood component storage bag (120) having one side more permeable than the other side of the bag and method of making the same.

Description

technical field [0001] The present invention relates to a bag or container for storing blood or blood components for subsequent transfusion to a patient, and further relates to a method of manufacturing such a bag. Background technique [0002] Blood components (eg, platelets) are typically stored for up to five or seven days prior to subsequent transfusion into the patient. The platelets used for storage are isolated from whole blood. Although an apheresis system can be used, a whole blood separator can also be used to separate platelets. In this procedure, whole blood is collected from a donor, and subsequently (i.e., after eight hours), the collected whole blood is separated into a platelet product, which may be referred to as an interim platelet unit or IPU. This platelet product does not meet the doses used for whole platelet medicine or therapy. Each isolated platelet fraction or IPU will thus be mixed with additional platelet products (which can be obtained from o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J1/10
CPCA61J1/10A61J1/1468Y10T156/10A61M1/02
Inventor 吉尔特·范韦格R·A·埃德里奇V·D·多尔塞克
Owner TERUMO BCT