Cell analyzer, erythrocyte agglutination amount measuring method and erythrocyte agglutination amount measuring system of the cell analyzer

A technology of red blood cell agglutination and measurement method, which is applied in the field of cell analyzer and its measurement method and system of red blood cell agglutination, which can solve the problems of low measurement accuracy and failure to give RBC agglutination alarm, etc., and achieve the effect of improving measurement accuracy

Active Publication Date: 2015-04-15
SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

When the sample is a hypochromic sample, the MCHC value when the sample does not agglutinate is lower than the normal reference range. When the sample has RBC agglutination, the MCHC value rises, but it is still within the reference range of a healthy person. At this time, it will not be given RBC agglutination alarm; in addition, for some hyperpigmented samples, the MCHC value itself is higher than the reference range of healthy people, and it is easy to be judged as a mismatch between RBC and HGB, so it is falsely alarmed as RBC agglutination
[0004] Therefore, the traditional detection method of erythrocyte agglutination has the disadvantage of low measurement accuracy.

Method used

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  • Cell analyzer, erythrocyte agglutination amount measuring method and erythrocyte agglutination amount measuring system of the cell analyzer
  • Cell analyzer, erythrocyte agglutination amount measuring method and erythrocyte agglutination amount measuring system of the cell analyzer
  • Cell analyzer, erythrocyte agglutination amount measuring method and erythrocyte agglutination amount measuring system of the cell analyzer

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Experimental program
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Effect test

Embodiment 1

[0105] Embodiment 1: A case of normal sample is detected, and its red blood cell count value is 4.38×10 12 / L. The diploid count value of red blood cells within the set volume range is calculated to be 0.2889×10 12 / L. Obtain a red blood cell count value of 0.29×10 within the set volume range 12 / L. Thus, it can be calculated that the hemagglutination amount of the red blood cells is 0.001×10 12 / L, did not reach the preset alarm threshold 0.035×10 12 / L, does not give a hemagglutination alarm.

Embodiment 2

[0106] Example 2: A case of erythrocyte agglutination sample was detected, and its erythrocyte count value was 2.08×10 12 / L, the calculated diploid count value of red blood cells within the set volume range is 0.067×10 12 / L. The red blood cell count value within the set volume range is 0.12×10 12 / L, after subtracting the number of diploids, it can be calculated that the amount of erythrocyte agglutination within the corresponding set volume range is 0.053×10 12 / L, greater than the preset alarm threshold 0.035×10 12 / L, can give red blood cell agglutination alarm.

Embodiment 3

[0107] Embodiment 3: Select 10 cases of positive samples of red blood cell agglutination and 100 cases of negative samples of red blood cell agglutination to detect by the cell agglutination alarm method in the present invention, all 10 cases of positive samples can report red blood cell agglutination alarm, and all 100 cases of negative samples do not give red blood cells Agglutination alarm.

[0108] The above data show that the method for measuring the amount of erythrocyte agglutination in the present invention has relatively high accuracy.

[0109] The application also discloses a measurement system for red blood cell agglutination, such as Figure 10 As shown, it includes an acquisition module 110 , a calculation module 120 , a statistics module 130 and a processing module 140 .

[0110] The acquisition module 110 is used to acquire cell data of the sample to be tested.

[0111] The cell data includes the volume size of the red blood cells to be tested and the number o...

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Abstract

A cell analyzer, an erythrocyte agglutination amount measuring method and an erythrocyte agglutination amount measuring system of the cell analyzer. The erythrocyte agglutination amount measuring method comprises following steps: (1) obtaining cell data of a to-be-test sample; (2) calculating the amount of polyploidies according to the cell data to obtain the amount of the targeted polyploidies; (3) counting the amount of to-be-test erythrocytes in a preset volume to obtain a total amount of the targeted erythrocytes; and (4) calculating a different value between the total amount of the targeted erythrocytes and the amount of the targeted polyploidies. According to the method, the erythrocyte agglutination amount in the to-be-test sample is obtained by calculating the different value between the total amount of the targeted erythrocytes and the amount of the targeted polyploidies, so that determination according to the contents of certain components in the cells is unnecessary. The method, compared with a conventional erythrocyte agglutination amount measuring method, is improved in measurement accuracy and is simple, convenient and quick.

Description

technical field [0001] The invention relates to the technical field of medical detection, in particular to a cell analyzer and a method and system for measuring erythrocyte agglutination. Background technique [0002] At present, medical particle analyzers have been widely used in the field of medical testing. For example, blood cell analyzers have become an important means of replacing microscopic examinations for blood routine analysis. Taking the measurement of red blood cells as an example, the measurement of red blood cells adopts the principle of micropore impedance. When it is suspended in the electrolyte solution and passes through the measurement hole, it will change the original constant resistance inside and outside the detection micropore, which is sensed by the sensor in the measurement hole and After the processing circuit generates electric pulses, the volume of red blood cells can be judged according to the size of the electric pulses, and the number of red b...

Claims

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Application Information

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IPC IPC(8): G01N15/10G01N15/02
Inventor 祁欢叶波王官振
Owner SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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