Processing method of scutellaria baicalensis

A technology of processing method and heating method, which can be applied in pharmaceutical formulations, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problems of high cost, uneven quality of medicinal materials, complicated production process, etc., to eliminate the price gap. , protection of wild resources, the effect of protecting wild resources

Inactive Publication Date: 2015-04-22
HEILONGJIANG UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Secondly, under cultivation conditions, the growth environment of plants is greatly improved by measures such as irrigation and fertilization. Under such conditions, the production of secondary metabolites (usually the medicinal components of Scutellaria baicalensis) is unfavorable, and cultivation in authentic areas is not suitable. It will ensure that the quality of medicinal materials will be greatly improved
Third, due to factors such as terrain, fertilization, and annual rainfall, the quality of medicinal materials in authentic regions is uneven, and it is difficult to ensure the improvement of the overall quality of medicinal materials
[0005] Disadvantages of prior art production of Scutellaria baicalensis: First, drought is the main factor to improve the quality of Scutellaria baicalensis, but reduces the yield of medicinal materials
Measures such as irrigation, which are generally highly respected under cultivation conditions, still cannot improve the quality of medicinal materials
Second, many natural conditions that affect the quality of medicinal materials are difficult to control artificially, so that the quality of many medicinal materials produced in authentic areas is not high-quality
Even under natural conditions, the level of plant secondary metabolism is determined by the degree of unsuitability of the external environment, which is a process of quantitative change, and is not the highest level of secondary metabolism produced by Scutellaria baicalensis. The best level, that is to say, although the overall impact of authentic areas on the quality of medicinal materials is higher than that of non-authentic areas, the potential has not yet been fully tapped
The high-quality potential of Scutellaria baicalensis is still not maximized, and the quality improvement is not significant
Third, the standardized production process of Chinese medicinal materials is complicated, the cycle is long, the cost is too high, and it is difficult to implement

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: at first the collected fresh roots of Scutellaria baicalensis are washed, then the fresh roots are treated at a constant temperature, the constant temperature temperature range is 30-60 ℃ and the fresh root is sprayed with clear water, the constant temperature temperature range is 30-65 ℃ and the The fresh roots are sprayed with clean water to keep the humidity of the fresh roots at 60-100%, and this state is maintained for 1-3 days, and the moisturizing treatment of the fresh roots is stopped.

[0022] Principle of processing method: The main component of Scutellaria baicalensis is chromone, and its key synthesis enzyme is phenylalanine ammonia lyase (PAL). The optimum temperature of this enzyme is very high, generally 30-65 °C. Among the four flavonoids with high content in Scutellaria baicalensis, baicalein has the highest bioavailability and the strongest activity. The enzymes that convert baicalin to baicalein require glucosidase, and the optimum temp...

Embodiment 2

[0024] Example 2: First, the collected fresh roots of Scutellaria baicalensis were washed, and then the fresh roots were subjected to a temperature change treatment, and the temperature change temperature range was 30-65 ° C and fresh water was sprayed on the fresh roots to keep the fresh root humidity at 60-100% , maintain this state for 1-3 days, and stop moisturizing the fresh root.

[0025] Principle of processing method: The main component of Scutellaria baicalensis is chromone, and its key synthesis enzyme is phenylalanine ammonia lyase (PAL). The optimum temperature of this enzyme is very high, generally 30-65 °C. Among the four flavonoids with high content in Scutellaria baicalensis, baicalein has the highest bioavailability and the strongest activity. The enzymes that convert baicalin to baicalein require glucosidase, and the optimum temperature of this enzyme is also very high, generally 30-65 °C. Although the roots of the newly harvested Scutellaria baicalensis lea...

Embodiment 3

[0027] Embodiment 3: at first the collected fresh roots of Scutellaria baicalensis are washed, and then the fresh roots are treated at a constant temperature and then a temperature change treatment, and the temperature change temperature range is 30-65 ° C and fresh water is sprayed on the fresh roots, and the fresh roots are covered. plastic to keep the fresh root humidity at 60-100%, maintain this state for 1-3 days, and stop moisturizing the fresh root.

[0028] Principle of processing method: The main component of Scutellaria baicalensis is chromone, and its key synthesis enzyme is phenylalanine ammonia lyase (PAL). Among the four flavonoids with high content in Scutellaria baicalensis, baicalein has the highest bioavailability and the strongest activity. The enzymes that convert baicalin to baicalein require glucosidase, and the optimum temperature of this enzyme is also very high, generally 30-65 °C. Although the roots of the newly harvested Scutellaria baicalensis leave ...

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PUM

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Abstract

The invention discloses a processing method of scutellaria baicalensis, and belongs to the technical field of processing of medicinal materials. The method comprises the following steps: firstly, cleaning collected fresh roots of scutellaria baicalensis; simultaneously heating the fresh roots, and carrying out moisturizing treatment on the fresh roots; keeping the humidity of the fresh roots at 60%-100%, maintaining the state for 1-3 days, and stopping moisturizing of the fresh roots. According to the processing method, the quality of the medicinal materials is improved; the primary metabolism level of the scutellaria baicalensis is improved; the high-yield potential of the medicinal materials is fully excavated; the components are purely natural; the processing technique is designed according to the influence on the quality of the medicinal materials caused by adverse natural environment; the biosynthesis is promoted by the natural process of scutellaria baicalensis biosynthesis, and is different from a biotransformation technology; no reagent is needed to promote high expression of the secondary metabolism pathway; the components contained by the medicinal material of the scutellaria baicalensis are purely natural; and no ingredient with toxic and side effects is generated.

Description

technical field [0001] The invention belongs to the technical field of medicinal material processing, and particularly relates to a processing method of Scutellaria baicalensis. Background technique [0002] Scutellaria baicalensis is a commonly used bulk medicinal material in China. It has antipyretic, antibacterial, sedative, blood pressure, and transaminase-lowering effects. Element. Phenylalanine ammonia lyase (PAL) is a key enzyme in the biosynthesis of chromone and regulates the rate of chromone synthesis. Through the literature search on phenylalanine ammonia lyase, it is found that only yam, ginkgo biloba, Dendrobium Huoshan, cabbage type rape, chickpea and other plants have been studied at present, but the highest level of this enzyme is found in all the plants studied. The suitable temperature is very high, generally 40-60 ℃. Generally, aglycone substances are easier to absorb. Scutellaria baicalensis contains Cimicifolin and Cimicifugain, and Scutellaria baical...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/539
Inventor 孟祥才付晓莹
Owner HEILONGJIANG UNIV OF CHINESE MEDICINE
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