Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Permselective asymmetric membranes

An asymmetric, semi-permeable technology, applied in the field of membrane preparation, which can solve problems such as low clearance and high protein loss

Active Publication Date: 2015-05-06
GAMBRO LUNDIA AB
View PDF14 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, membranes prepared using only polyvinylpyrrolidone with high molecular weight (such as PVP K80 or K90) tend to show lower clearance of solutes such as urea or vitamin B12 from blood and higher protein loss

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Permselective asymmetric membranes
  • Permselective asymmetric membranes
  • Permselective asymmetric membranes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0063] i) Preparation of filter

[0064] Two types of filters (=dialyzers) were used in the examples. The first type of filter contains about 12,000 fibers and has an effective surface area of ​​about 1.7m 2 ; the second type of filter contains about 17,000 fibers and has an effective surface area of ​​about 2.72m 2 . The effective surface area A is calculated according to formula (1):

[0065] A=π·d i l n[cm 2 ] (1)

[0066] in

[0067] d i = Inner diameter of fiber [cm]

[0068] n = number of fibers

[0069] l = effective fiber length [cm]

[0070] The filter has a cylindrical housing with two connectors for dialysis fluid and caps applied at both ends, each cap having a central blood connector. The manufacturing method (after fiber winding) consists of the following main steps:

[0071] Transfer fiber bundles (about 30 cm in length) into the shell;

[0072] Both ends of the fibers in the bundle are closed by a closing process;

[0073] The fibers are p...

Embodiment 1

[0123] By adding polyethersulfone ( E 6020, BASF SE) and polyvinylpyrrolidone ( K90HM, BASF SE) and distilled water were dissolved in N-methyl-2-pyrrolidone (NMP) to prepare a polymer solution. The weight fraction of different components in the polymer spinning solution is: PES:PVP K90HM:H 2 O:NMP=14:3.5:3:79.5.

[0124] The membrane was formed by heating the polymer solution to 50°C and passing the solution through a spinneret with a center fluid consisting of 56 wt% water and 44 wt% NMP. The temperature of the spinneret was 55°C and the temperature of the spin shaft was 52°C. Hollow fiber membranes were formed at a spinning speed of 50 m / min. The capillary transfer of the liquid leaving the spinneret into a water bath (ambient temperature). The distance between the spinning head and the precipitation bath was 100 cm.

[0125]The hollow fiber membranes were washed by passing them through 5 different water baths. After leaving the fifth water bath, the fibers were fed...

Embodiment 2

[0132] Example 1 was repeated with a spinneret temperature of 56°C and a spin shaft temperature of 53°C.

[0133] Filter performance was tested as described above. The results are shown in Table 6.

[0134] Table 6

[0135]

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
The inside diameter ofaaaaaaaaaa
Weight average molecular weightaaaaaaaaaa
Number average molecular weightaaaaaaaaaa
Login to View More

Abstract

The present invention relates to membranes being suitable e.g. for hemodialysis, hemodiafiltration, or hemofiltration of blood. The invention also relates to a process for the production of the membranes; and to devices comprising the membranes.

Description

technical field [0001] The present invention relates to membranes suitable for eg hemodialysis, hemodiafiltration or hemofiltration. The invention also relates to methods for preparing the membrane; and devices comprising the membrane. Background technique [0002] Synthetic membranes used in hemodialysis, hemodiafiltration, or hemofiltration are often constructed of hydrophobic polymers blended with hydrophilic polymers to improve the compatibility of the membrane with blood. Generally, polysulfone, polyethersulfone or polyarylethersulfone is used as the hydrophobic polymer, and polyvinylpyrrolidone is used as the hydrophilic polymer. [0003] WO 2004 / 056459 A1 discloses permselective asymmetric membranes suitable for hemodialysis comprising at least one hydrophobic polymer, such as polyethersulfone, and at least one hydrophilic polymer, such as polyvinylpyrrolidone. The outer surface of the hollow fiber membrane has pores of 0.5 to 3 μm, and the number of pores in the ou...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): B01D71/68B01D69/06B01D69/08B01D67/00B01D61/00
CPCB01D63/023B01D71/68B01D2325/34B01D71/28B01D69/061B01D67/00111B01D69/08
Inventor 拉尔夫·蒙达乔基姆·勒歇尔马丁·莱姆普菲
Owner GAMBRO LUNDIA AB
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com