Permselective asymmetric membranes

An asymmetric, semi-permeable technology, applied in the field of membrane preparation, which can solve problems such as low clearance and high protein loss

Active Publication Date: 2015-05-06
GAMBRO LUNDIA AB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

On the other hand, membranes prepared using only polyvinylpyrrolidone with high molecular weight (such as PVP K8

Method used

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Examples

Experimental program
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Effect test

Embodiment

[0063] i) Preparation of filter

[0064] Two types of filters (=dialyzers) were used in the examples. The first type of filter contains about 12,000 fibers and has an effective surface area of ​​about 1.7m 2 ; the second type of filter contains about 17,000 fibers and has an effective surface area of ​​about 2.72m 2 . The effective surface area A is calculated according to formula (1):

[0065] A=π·d i l n[cm 2 ] (1)

[0066] in

[0067] d i = Inner diameter of fiber [cm]

[0068] n = number of fibers

[0069] l = effective fiber length [cm]

[0070] The filter has a cylindrical housing with two connectors for dialysis fluid and caps applied at both ends, each cap having a central blood connector. The manufacturing method (after fiber winding) consists of the following main steps:

[0071] Transfer fiber bundles (about 30 cm in length) into the shell;

[0072] Both ends of the fibers in the bundle are closed by a closing process;

[0073] The fibers are p...

Embodiment 1

[0123] By adding polyethersulfone ( E 6020, BASF SE) and polyvinylpyrrolidone ( K90HM, BASF SE) and distilled water were dissolved in N-methyl-2-pyrrolidone (NMP) to prepare a polymer solution. The weight fraction of different components in the polymer spinning solution is: PES:PVP K90HM:H 2 O:NMP=14:3.5:3:79.5.

[0124] The membrane was formed by heating the polymer solution to 50°C and passing the solution through a spinneret with a center fluid consisting of 56 wt% water and 44 wt% NMP. The temperature of the spinneret was 55°C and the temperature of the spin shaft was 52°C. Hollow fiber membranes were formed at a spinning speed of 50 m / min. The capillary transfer of the liquid leaving the spinneret into a water bath (ambient temperature). The distance between the spinning head and the precipitation bath was 100 cm.

[0125]The hollow fiber membranes were washed by passing them through 5 different water baths. After leaving the fifth water bath, the fibers were fed...

Embodiment 2

[0132] Example 1 was repeated with a spinneret temperature of 56°C and a spin shaft temperature of 53°C.

[0133] Filter performance was tested as described above. The results are shown in Table 6.

[0134] Table 6

[0135]

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Abstract

The present invention relates to membranes being suitable e.g. for hemodialysis, hemodiafiltration, or hemofiltration of blood. The invention also relates to a process for the production of the membranes; and to devices comprising the membranes.

Description

technical field [0001] The present invention relates to membranes suitable for eg hemodialysis, hemodiafiltration or hemofiltration. The invention also relates to methods for preparing the membrane; and devices comprising the membrane. Background technique [0002] Synthetic membranes used in hemodialysis, hemodiafiltration, or hemofiltration are often constructed of hydrophobic polymers blended with hydrophilic polymers to improve the compatibility of the membrane with blood. Generally, polysulfone, polyethersulfone or polyarylethersulfone is used as the hydrophobic polymer, and polyvinylpyrrolidone is used as the hydrophilic polymer. [0003] WO 2004 / 056459 A1 discloses permselective asymmetric membranes suitable for hemodialysis comprising at least one hydrophobic polymer, such as polyethersulfone, and at least one hydrophilic polymer, such as polyvinylpyrrolidone. The outer surface of the hollow fiber membrane has pores of 0.5 to 3 μm, and the number of pores in the ou...

Claims

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Application Information

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IPC IPC(8): B01D71/68B01D69/06B01D69/08B01D67/00B01D61/00
CPCB01D71/28B01D63/023B01D67/0011B01D69/06B01D69/08B01D71/68B01D2325/34
Inventor 拉尔夫·蒙达乔基姆·勒歇尔马丁·莱姆普菲
Owner GAMBRO LUNDIA AB
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