Norfloxacin capsules and preparation method thereof

The technology of norfloxacin and capsule is applied in the field of norfloxacin capsule and its preparation, which can solve the problems of unstable nature, insoluble in water, multiple side effects, etc. High bioavailability effect

Inactive Publication Date: 2015-05-13
SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ordinary preparations of norfloxacin are insoluble in water, have low oral bioavailability, unstable properties,

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0011] Example 1:

[0012] (1) Screening of auxiliary materials: corn starch, 2-hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl starch, microcrystalline cellulose, talc, hard Magnesium fatty acid was passed through a 100-mesh sieve respectively; (2) Ingredients: Weigh 45g norfloxacin, 10g corn starch, 10g 2-hydroxypropyl-β-cyclodextrin, 5g microcrystalline cellulose, and carboxymethyl 12g of sodium cellulose, 13g of sodium carboxymethyl starch, 2g of talc, 3g of magnesium stearate; (3) Total blend: will be norfloxacin, corn starch, 2-hydroxypropyl-β-cyclodextrin, Microcrystalline cellulose, sodium carboxymethyl cellulose, sodium carboxymethyl starch, talc, and magnesium stearate are ground into a paste mixture at a temperature of 25°C for 6 hours; (4) drying: Step (3) ) The pasty mixture is spread flat, and the vacuum degree is 4.3×10 at a temperature of 44℃ 4 Pa vacuum dryer for drying; (5) Granulation: pulverize th...

Example Embodiment

[0013] Example 2:

[0014] (1) Screening of auxiliary materials: tapioca starch, 2-hydroxypropyl-β-cyclodextrin, microcrystalline cellulose, sodium carboxymethyl starch, compressible starch, calcium carboxymethyl cellulose, magnesium stearate , Silica separately through a 100 mesh sieve; (2) Ingredients: Weigh 40g norfloxacin, 15g tapioca starch, 10g 2-hydroxypropyl-β-cyclodextrin, 5g microcrystalline cellulose, carboxymethyl Sodium starch base 10g, compressible starch 10g, carboxymethyl cellulose calcium 5g, magnesium stearate 3g, silicon dioxide 2g; (3) Total blend: will be norfloxacin, tapioca starch, 2-hydroxypropyl -Β-cyclodextrin, microcrystalline cellulose, sodium carboxymethyl starch, compressible starch, calcium carboxymethyl cellulose, magnesium stearate, silicon dioxide, ground for 5 hours at a temperature of 27 ℃ Paste mixture; (4) Drying: spread the pasty mixture in step (3) flat, at a temperature of 45°C and a vacuum of 4.2×10 4 Pa vacuum dryer for drying; (5) Gran...

Example Embodiment

[0015] Example 3:

[0016] (1) Screening of auxiliary materials: corn starch, tapioca starch, 2-hydroxypropyl-β-cyclodextrin, sodium carboxymethyl cellulose, microcrystalline cellulose, low-substituted carboxyhydroxypropyl cellulose, stearic acid Magnesium and polyethylene glycol are respectively passed through a 100 mesh sieve; (2) Ingredients: Weigh 40g norfloxacin, 10g corn starch, 15g tapioca starch, 10g 2-hydroxypropyl-β-cyclodextrin, carboxymethyl Base cellulose sodium 10g, microcrystalline cellulose 5g, low-substituted carboxyhydroxypropyl cellulose 10g, magnesium stearate 3g, polyethylene glycol 2g; (3) Total blend: Norfloxacin, corn starch, Tapioca starch, 2-hydroxypropyl-β-cyclodextrin, sodium carboxymethyl cellulose, microcrystalline cellulose, low-substituted carboxyhydroxypropyl cellulose, magnesium stearate, polyethylene glycol; at a temperature of 25 Grind at ℃ for 6 hours to form a paste mixture; (4) Drying: spread the paste mixture in step (3) flat, at a tempera...

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PUM

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Abstract

The invention discloses norfloxacin capsules and a preparation method thereof. The norfloxacin capsules comprise a filling agent, a disintegrating agent and a lubricating agent. The preparation method comprises the following steps of: (1) sieving auxiliary materials; (2) batching materials; (3) totally blending; (4) drying; (5) granulating; (6) determining; and (7) filling and packaging. The norfloxacin capsules and the preparation method disclosed by the invention have the advantages that by improvement on a formula and the preparation method, the dissolving-out degree of norfloxacin is increased, the absorption of the norfloxacin in a body is improved and the drug stability is also enhanced.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a norfloxacin capsule and a preparation method thereof. Background technique [0002] Norfloxacin is a broad-spectrum fluoroquinolone antibacterial antibiotic, especially for aerobic Gram-negative bacilli, and has good antibacterial activity against most bacteria of the Enterobacteriaceae family. It also has antibacterial activity against multidrug-resistant bacteria. It also has good antibacterial effect on penicillin-resistant Neisseria gonorrhoeae, Haemophilus influenzae and Moraxella catarrhalis. Norfloxacin is a fungicide that inhibits DNA synthesis and replication by acting on the A subunit of bacterial DNA helicase, leading to bacterial death. It is suitable for urinary tract infection, gonorrhea, prostatitis, intestinal infection, typhoid fever and other Salmonella infections caused by sensitive bacteria. [0003] Ordinary preparations of norfloxacin are insoluble in w...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/496A61P31/04
Inventor 钱令刘俊华齐鸿达
Owner SHANGHAI HUAYUAN ANHUI RENJI PHARMA
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