Calcium titanate up-conversion luminescence nanoparticle and preparation method thereof

A nanoparticle, calcium titanate technology, applied in the field of biological tissue imaging, drug tracking and light-emitting devices, multifunctional application-type inorganic advanced nanomaterials, can solve the limitations of calcium titanate biomedicine, inability to exist stably, and irregular morphology. Uniformity and other problems, to achieve the effect of uniform size, easy operation and good appearance

Inactive Publication Date: 2015-05-20
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, so far, the calcium titanate particles synthesized by researchers are mostly in micron and submicron scales, with uneven morphology and low luminous efficiency.
And due to the large size, it cannot exist stably in the aqueous phase, which greatly limits the biomedical application of calcium titanate

Method used

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  • Calcium titanate up-conversion luminescence nanoparticle and preparation method thereof
  • Calcium titanate up-conversion luminescence nanoparticle and preparation method thereof
  • Calcium titanate up-conversion luminescence nanoparticle and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] (1) Dissolve 4.2mmol of calcium nitrate tetrahydrate, 0.05mmol of erbium nitrate pentahydrate, and 0.75mmol of ytterbium nitrate pentahydrate in 10ml of absolute ethanol, and mix them thoroughly under magnetic stirring for 30min to obtain solution A.

[0024] (2) Add 5mmol tetrabutyl titanate to 10ml ethanol solution containing 1.0g citric acid, stir for 30min and mix evenly, then add the obtained solution drop by drop into solution A with a disposable straw, stir for 60min to make it evenly mixed Obtain the precursor solution.

[0025] (3) Add 0.80 sodium edetate as a compounding agent to 100 ml of deionized water, and adjust to pH=12 by adding ammonia water.

[0026] (4) Push the precursor solution into the solution obtained in (3) with a push pump syringe at a speed of 90ml / h. Continue to stir for 1h until the mixture is homogeneous. The resulting solution was stirred and heated in an oil bath at 120° C., and then allowed to stand to room temperature after 3 h.

...

Embodiment 2

[0030] (1) Dissolve 4.15mmol of calcium nitrate tetrahydrate, 0.1mmol of erbium nitrate pentahydrate, and 0.75mmol of ytterbium nitrate pentahydrate in 10ml of absolute ethanol, and mix them thoroughly under magnetic stirring for 30min to obtain solution A.

[0031] (2) Add 5mmol tetrabutyl titanate to 10ml ethanol solution containing 1.0g citric acid, stir for 30min and mix evenly, then add the obtained solution drop by drop into solution A with a disposable straw, stir for 60min to make it evenly mixed Obtain the precursor solution.

[0032] (3) Add 0.85 mmol of the complexing agent sodium edetate to 100 ml of deionized water, and add ammonia water to adjust the pH to 10.

[0033] (4) Push the precursor solution into the solution obtained in (3) with a push pump syringe at a speed of 90ml / h. Continue to stir for 1h until the mixture is homogeneous. The resulting solution was stirred and heated in an oil bath at 120° C., and then allowed to stand to room temperature after 3...

Embodiment 3

[0037](1) Dissolve 3.95mmol of calcium nitrate tetrahydrate, 0.15mmol of erbium nitrate pentahydrate, and 0.9mmol of ytterbium nitrate pentahydrate in 20ml of absolute ethanol, and mix them thoroughly under magnetic stirring for 30min to obtain solution A.

[0038] (2) Add 5mmol tetrabutyl titanate to 10ml ethanol solution containing 1.0g citric acid, stir for 30min and mix evenly, then add the obtained solution drop by drop into solution A with a disposable straw, stir for 60min to make it evenly mixed Obtain the precursor solution.

[0039] (3) Add 1.05 mmol of the complexing agent sodium edetate into 100 ml of deionized water, and adjust the pH to 11 by adding ammonia water.

[0040] (4) Push the precursor solution into the solution obtained in (3) with a push pump syringe at a speed of 90ml / h. Continue to stir for 1h until the mixture is homogeneous. The resulting solution was stirred and heated in an oil bath at 120° C., and then allowed to stand to room temperature aft...

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Abstract

The invention discloses a calcium titanate up-conversion luminescence nanoparticle prepared by using the combination of a sol-gel method and a coprecipitation method. By adding rare earth elements ytterbium and erbium, an up-conversion luminescence effect can be achieved, and the method is simple, and strong in maneuverability. Obtained materials are calcium titanate luminescence nanoparticles with an average particle size of 65 nm and with uniform size distribution, good monodispersity and good biocompatibility. The nanoparticle has a wide application prospect in the biomedicine, for example, the nanoparticle can be used as biological probes, tissue or cell imaging and drug tracers and the like; and the nanoparticle also has important applications in the field of light-emitting devices.

Description

technical field [0001] The invention belongs to the technical field of multifunctional application-type inorganic advanced nanomaterials, in particular to a monodisperse rare earth-doped calcium titanate nanoparticle with upconversion luminescence effect and a preparation method thereof, which can be applied to biological tissue imaging, drug tracing and field of light emitting devices. Background technique [0002] Rare-earth element up-conversion luminescent materials are an important class of luminescent materials, which can be excited by long-wavelength light sources and continuously excite shorter-wavelength light. Compared with organic dyes and ultraviolet light, rare earth-doped up-conversion nanomaterials have excellent properties such as low excitation light source energy, less tissue damage, excellent optical properties, good chemical stability, low biological tissue absorption, and large penetration ability. extensive attention and research. [0003] In recent ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C09K11/67B82Y40/00B82Y30/00B82Y20/00
Inventor 李翔李彬彬李杨杨韩高荣
Owner ZHEJIANG UNIV
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