Chiral phosphorous ligand as well as metal catalyst containing ligand and application of chiral phosphorous ligand and catalyst

A technology of ligand compounds and transition metals, applied in the field of gossypol synthesis, can solve the problems of poor reaction selectivity and low yield, etc.
CN104650145AInactive Publication Date: 2015-05-27SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
1 Cites 5 Cited by

Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
SHANGHAI INST OF ORGANIC CHEMISTRY - CHINESE ACAD OF SCI
Publication Date
2015-05-27
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention relates to a chiral phosphorous ligand as well as a metal catalyst containing the ligand and an application of the chiral phosphorous ligand and the catalyst, and particularly discloses a bidentate phosphine-phosphonate ligand compound or an enantiomer, a despinner or a diastereoisomer thereof, wherein the bidentate phosphine-phosphonate ligand compound has a structure as shown in formula I in the specification. The invention further discloses a transition metal catalyst containing the bidentate phosphine-phosphonate ligand compound and an application of the transition metal catalyst to catalyzing coupling reaction for synthesizing noncyclic alkyl aromatic hydrocarbon.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The present invention relates to the field of metal catalysts. More specifically, the present invention relates to novel bidentate phosphine-phosphine oxygen ligand compounds and metal catalysts containing the ligand compounds and their Suzuki- Miyaura coupling reaction and its application in a new method for the synthesis of gossypol. Background technique

[0002] The direct coupling of carbon-carbon bonds catalyzed by transition metals is an important method for the synthesis of a series of alkyl-substituted aromatic compounds, and it is widely used in pharmaceutical research. However, the existing methods still have great limitations for large steric hindrance carbon-carbon bond coupling, and the applicable high-efficiency catalysts and ligands are still rare. Especially for the formation of carbon-carbon bonds between bulky aryl groups and alkyl groups, there is a lack of efficient methods. The main reason is the presence of β-hydrogen in the alk...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More