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Compound oxytetracycline injection and preparation method thereof

A technology of injection and oxytetracycline, which is applied in pharmaceutical formulations, active ingredients of tetracycline, and medical preparations containing active ingredients, etc., can solve the problems of granulocyte reduction and insignificant effect, and achieves high concentration of liquid medicine and enhanced killing effect. The ability of dead bacteria, the effect of low production cost

Active Publication Date: 2015-06-03
华北制药集团动物保健品有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, aminopyrine can cause myelosuppression and can form nitrosamine carcinogens, and can cause neutropenia in pigs
[0004] In the oxytetracycline injection disclosed in the invention patent CN200710052243, the compound preparation composed of oxytetracycline and trimethoprim has a synergistic effect on diseases caused by bacterial infections in pigs, but trimethoprim can only increase The bactericidal ability of oxytetracycline has no significant effect on pigs with high fever caused by bacteria

Method used

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  • Compound oxytetracycline injection and preparation method thereof
  • Compound oxytetracycline injection and preparation method thereof
  • Compound oxytetracycline injection and preparation method thereof

Examples

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Comparison scheme
Effect test

Embodiment 1

[0041] A kind of compound oxytetracycline injection, every 100ml injection comprises the component and content thereof: oxytetracycline 5g, ketoprofen 1g, ethanol 10ml, propylene glycol 10ml, α-pyrrolidone 20ml, sodium formaldehyde sulfoxylate 0.2 g, magnesium chloride 1.8g, lidocaine hydrochloride 0.2g, ethanolamine 2.0ml, and the balance is water for injection.

[0042] Take each raw material according to the content of above-mentioned each component, prepare the compound oxytetracycline injection of 100ml according to the following steps:

[0043]①Take 55ml of water for injection, heat to 55°C, add sodium formaldehyde sulfoxylate and lidocaine hydrochloride to dissolve, then add magnesium chloride, stir to dissolve, and form A solution, set aside;

[0044] ② Dissolve ketoprofen with 10ml of ethanol, and make B solution, set aside;

[0045] ③ Add propylene glycol and α-pyrrolidone to solution A, heat to about 65°C, add oxytetracycline, stir to dissolve, and prepare solution...

Embodiment 2

[0048] A compound oxytetracycline injection, the components and contents contained in every 100ml injection are: oxytetracycline 10g, ketoprofen 2g, ethanol 10ml, glycerin formal 5ml, α-pyrrolidone 25ml, formaldehyde sulfoxylate Sodium hydrogen 0.4g, magnesium chloride 3.5g, lidocaine hydrochloride 0.2g, ethanolamine 3.7ml, and the balance is water for injection.

[0049] Take each raw material according to the content of above-mentioned each component, prepare the compound oxytetracycline injection of 100ml according to the following steps:

[0050] ①Take 45ml of water for injection, heat to 60°C, add sodium formaldehyde sulfoxylate and lidocaine hydrochloride to dissolve, then add magnesium chloride, stir to dissolve, and form A solution, set aside;

[0051] ② Dissolve ketoprofen with ethanol, and make solution B, and set aside;

[0052] ③ Add glycerol methylal and α-pyrrolidone to solution A, heat to 70°C, add oxytetracycline, stir to dissolve, and prepare solution C for l...

Embodiment 3

[0055] A kind of compound oxytetracycline injection, every 100ml injection contains each component and its content are: oxytetracycline 20g, ketoprofen 3g, ethanol 10ml, propylene glycol 10ml, α-pyrrolidone 40ml, sodium formaldehyde sulfoxylate 0.5g, magnesium oxide 2.0g, lidocaine hydrochloride 0.5g, ethanolamine 1.5ml, and the balance is water for injection.

[0056] Take each raw material according to the content of above-mentioned each component, carry out the preparation of compound oxytetracycline injection according to the following steps:

[0057] ①Use 20ml of water for injection, heat to 65°C, add sodium formaldehyde sulfoxylate and lidocaine hydrochloride to dissolve, then add magnesium oxide, stir evenly, form A solution, and set aside;

[0058] ② Dissolve ketoprofen with ethanol, and make solution B, and set aside;

[0059] ③ Add propylene glycol and α-pyrrolidone to solution A, heat to about 75°C, add oxytetracycline, stir to dissolve, and prepare solution C for ...

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Abstract

The invention discloses compound oxytetracycline injection and a preparation method, particularly relates to compound injection applied to animals. Every 100ml of injection comprises the following components: 5-23g of oxytetracycline, 1-5g of ketoprofen, 30-80ml of an organic slvent, 0.2-2g of an antioxidant, 1.8-8g of a complexing agent, 0.2-1g of a pain killer, 1-7ml of a pH regulator and the balance of injection water. The oxytetracycline and the ketoprofen are prepared into the compound preparation, wherein the oxytetracycline is wide-spectrum antibiotics, and the ketoprofen is an antipyretic-analgesic anti-inflammatory agent, so that the matched using effect is good. The oxytetracycline and the ketoprofen are injection dosage forms; in the past, when the drug is used on a pig, oxytetracycline is injected once on the pig and then the ketoprofen is injected once, however, at present, the compound injection only needs to inject once, so that the pains of the pig are reduced, the site injection work of veterinarians is performed in a more facilitated manner, and the working efficiency of the veterinarians is improved. Due to the use of the compound injection, the cost of packaging, transporting and the like of a medicament bottle are reduced, and the cost is reduced.

Description

technical field [0001] The invention relates to an injection and a preparation method thereof, in particular to a compound oxytetracycline injection and a preparation method thereof. Background technique [0002] Oxytetracycline has a broad-spectrum antibacterial effect, and has a certain inhibitory effect on sensitive bacteria including pneumococcus, streptococcus, some staphylococcus, bacillus anthracis, bacillus tetani, mycoplasma hyopneumoniae, chlamydia and spirochetes. [0003] The compound oxytetracycline injection disclosed in the invention patent CN200710150169 uses oxytetracycline and aminopyrine as the main components of the injection, which is effective for hyperthermia caused by bacterial infection in pigs, and has the effect of treating both symptoms and root causes. Aminopyrine has strong antipyretic and analgesic effect, which is slow and long-lasting, and its anti-inflammatory and anti-rheumatic effect is similar to that of aspirin. However, aminopyrine can...

Claims

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Application Information

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IPC IPC(8): A61K45/06A61K31/65A61K9/08A61P31/04A61P29/00A61K31/192A61K31/167
Inventor 吴金波王秀英董乔乔黄娜谢勇王卓李京士范永刚段瑞亭
Owner 华北制药集团动物保健品有限责任公司
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