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A kind of pharmaceutical composition containing doxofylline

A technology of doxofylline and its composition, which is applied in the field of pharmaceutical compositions containing doxofylline, can solve problems affecting the quality of medicines and safety of clinical medication, and achieve easy industrial production, low production cost, and good stability Effect

Active Publication Date: 2017-09-29
长春卓悦健康科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The emergence of this phenomenon has greatly affected the quality of drugs and the safety of clinical medication.

Method used

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  • A kind of pharmaceutical composition containing doxofylline
  • A kind of pharmaceutical composition containing doxofylline
  • A kind of pharmaceutical composition containing doxofylline

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1) Weigh 40g of mannitol and 1g of disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution with a pH of 5.7 and dissolve them in 700ml of water for injection, stir to dissolve;

[0062] 2) Add 15g doxofylline in the above-mentioned obtained solution, stir and dissolve;

[0063] 3) Measure the pH value of the solution obtained above, adjust the pH value of the solution to 6.0 with 0.2 g diethylamine, dilute to the total volume with water for injection, and stir;

[0064] 4) Add 0.1% activated carbon for needles to the solution obtained above, stir for adsorption, and filter to remove carbon;

[0065] 5) Fill the above-mentioned obtained solution in ampoules;

[0066] 6) The injection is autoclaved at 121°C for 15 minutes;

[0067] 7) Light inspection, that is to say.

Embodiment 2

[0069] 1) Weigh 45g of mannitol, 1.3g of disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution with pH 5.7 and dissolve in 700ml of water for injection, stir to dissolve;

[0070] 2) Add 16g doxofylline to the solution obtained above, stir and dissolve;

[0071] 3) Measure the pH value of the solution obtained above, adjust the pH value of the solution to 6.1 with 0.3 g of diethylamine, dilute to the total volume with water for injection, and stir;

[0072] 4) Add 0.1% activated carbon for needles to the solution obtained above, stir for adsorption, and filter to remove carbon;

[0073] 5) Fill the above-mentioned obtained solution in ampoules;

[0074] 6) The injection is autoclaved at 121°C for 15 minutes;

[0075] 7) Light inspection, that is to say.

Embodiment 3

[0077] 1) Weigh 50g of mannitol, 2.3g of disodium hydrogen phosphate-sodium dihydrogen phosphate buffer solution with pH 5.7 and dissolve in 700ml of water for injection, stir to dissolve;

[0078] 2) Add 17g doxofylline to the solution obtained above, stir and dissolve;

[0079] 3) Measure the pH value of the solution obtained above, adjust the pH value of the solution to 6.0 with 0.4 g of diethylamine, dilute to the total volume with water for injection, and stir;

[0080] 4) Add 0.1% activated carbon for needles to the solution obtained above, stir for adsorption, and filter to remove carbon;

[0081] 5) Fill the above-mentioned obtained solution in ampoules;

[0082] 6) The injection is autoclaved at 121°C for 15 minutes;

[0083] 7) Light inspection, that is to say.

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Abstract

The invention belongs to the technical field of medicine, and the invention provides a pharmaceutical composition containing doxofylline and its preparation, comprising doxofylline, mannitol, disodium hydrogen phosphate-sodium dihydrogen phosphate buffer and diethylamine . The injection prepared from the composition of the invention has good solubility and good stability; the injection prepared from the composition is convenient to use, convenient for storage and transportation, has a simple preparation method, is easy to industrialized production, and has low production cost.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing doxofylline. Background technique [0002] Doxofylline, a derivative of methylxanthine, is a bronchodilator that acts directly on the bronchi to relax bronchial smooth muscle. By inhibiting the action of phosphodiesterase in smooth muscle cells, it relaxes smooth muscle, thereby achieving the effect of inhibiting asthma. [0003] Doxofylline preparations have been widely used in the treatment of asthma and respiratory diseases since they were introduced into China in the 1990s. However, since the doxofylline preparation is a weakly alkaline preparation, there are certain defects in the physical and chemical stability of the preparation. Especially under the condition of small-capacity injection (commercially available products are 0.1g / 10ml; 0.2g / 10ml; 0.3g / 20ml three specifications, of which 0.1g / 10ml is the most commonly us...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K31/522A61K47/18A61P11/00A61P11/06
Inventor 张春苗王小雪徐璐田晶
Owner 长春卓悦健康科技有限公司