Preparation method of goserelin
A 1.0.2mol5-oxopro-his-nhnh2, dimethylformamide technology, applied in chemical instruments and methods, specific peptides, luteinizing hormone-releasing hormone and other directions, can solve the problems of high production cost and complex manufacturing process, Achieve the effect of low production cost and simple preparation process
Inactive Publication Date: 2015-07-01
李磊
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Problems solved by technology
Due to the current process of producing goserelin, the manufacturing process is complicated and the production cost is high
Method used
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[0006] Now in conjunction with the present invention for further detailed description.
[0007] A kind of preparation method of goserelin of the present invention, concrete steps are as follows: 1.0.2mol5-oxoPro-His-NHNH Suspended in the mixed solvent of 0.9mL dimethylformamide and 0.7mL dimethyl sulfoxide, in 0 Under stirring at ℃, add 0.8mmol5.7mol / L hydrochloric acid dioxane solution, stir vigorously for 5min to obtain a clear solution.
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The invention relates to a preparation method of goserelin, wherein the production method comprises the following specific steps: suspending 1.0.2 mol of 5-oxoPro-His-NHNH2 in a mixed solvent of 0.9 mL of dimethylformamide and 0.7 mL of dimethylsulfoxide, at the temperature of 0 DEG C and under stirring, adding 0.8 mmol of dioxane solution with 5.7 mol / L hydrochloric acid, vigorously stirring for 5 min, and thus obtaining a clarified solution. The preparation method of goserelin is simple in preparation process and low in production cost.
Description
technical field [0001] The invention relates to the field of medicine preparation, in particular to a preparation method of goserelin. Background technique [0002] Goserelin is a synthetic analogue of luteinizing hormone-releasing hormone. Long-term use can inhibit the secretion of luteinizing hormone in the pituitary gland, thereby causing a decrease in serum testosterone in men and serum estradiol in women. One effect is reversible. Because currently it is in the process of producing goserelin, the manufacturing process is complicated and the production cost is high. Contents of the invention [0003] The technical problem to be solved by the present invention is: in order to overcome the above-mentioned problems, a preparation method of goserelin is provided. [0004] The technical solution adopted by the present invention to solve the technical problem is: a preparation method of goserelin, the specific steps are as follows: suspending 1.0.2mol5-oxoPro-His-NHNH2 in ...
Claims
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IPC IPC(8): C07K7/23
Inventor 李磊
Owner 李磊
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