A multi-channel in vitro metabolic real-time monitoring device

A real-time monitoring and multi-channel technology, which is applied in biochemical cleaning devices, enzymology/microbiology devices, tissue cell/virus culture devices, etc. Good consistency between conditions, high sensitivity and high efficiency

Active Publication Date: 2017-12-19
RAYCAN TECH CO LTD SU ZHOU
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Problems solved by technology

Among the above three detection methods, the fully enclosed gamma counter can only monitor one sample at a time, and cannot distinguish and monitor multiple culture dishes at all; PET and gamma cameras cannot accurately distinguish the adjacent areas of two culture channels. Counting, and the problem of different detection sensitivities for different culture channels, are not suitable as a monitoring device for high-throughput experiments

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  • A multi-channel in vitro metabolic real-time monitoring device
  • A multi-channel in vitro metabolic real-time monitoring device
  • A multi-channel in vitro metabolic real-time monitoring device

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Embodiment Construction

[0050] The invention discloses a multi-channel real-time monitoring device for in vitro metabolism. The multi-channel real-time monitoring device for in vitro metabolism can acquire and display the radioactive activity distribution information of multiple culture channels in real time, and can obtain the metabolite intake in the whole experimental process. The curve can more completely reflect the influence of the parameters to be studied on the target biological tissue, and high-throughput experiments can be carried out.

[0051] The technical solutions in the embodiments of the present invention will be described in detail below in conjunction with the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative eff...

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Abstract

A multichannel in-vitro metabolism real-time monitoring apparatus includes a radiation probing apparatus and a constant flow culture apparatus. The constant flow culture apparatus includes a liquid supply bottle, a waste liquid bottle, a multichannel infusion apparatus, and a multichannel liquid separation apparatus. The radiation probing apparatus has two groups of probing modules with flat structures, which are separately disposed on two sides of multichannel biochemical culture apparatuses and are used for recording radiation activities in the multichannel biochemical culture apparatuses in real time.

Description

technical field [0001] The invention relates to the fields of radiation detection and biomedical metabolism analysis, in particular to a multi-channel in vitro metabolism real-time monitoring device based on real-time coincidence detection and continuous culture. Background technique [0002] At present, in the fields of biology and medicine, in order to carry out relevant biological behaviors of organisms such as cells, tissues and organs, such as the characteristics of ingesting glucose, amino acids, fatty acids and other metabolic substances of organisms, adding radionuclide labels to biochemical culture equipment is widely used. The above-mentioned metabolites are used for in vitro culture of living biological tissues, and then the radioactive activity distribution information of the samples is detected by radiation detectors to reflect the detection scheme of the uptake of the markers by the samples. Compared with another commonly used fluorescent imaging-based detectio...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12M3/00C12M1/34
CPCC12M41/00C12M41/32C12M41/36C12M29/10C12M41/46C12M23/08
Inventor 黄钢吴小可王璐瑶朱俊谢庆国
Owner RAYCAN TECH CO LTD SU ZHOU
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