Antibacterial applications of vitamin D and vitamin D composition

Abstract

Uses of a vitamin D compound in the preparation of drugs for preventing or treating cystitis, urethritis and / or urinary tract infection, as well as a pharmaceutical composition, a pharmaceutical preparation and a kit that comprise the vitamin D compound, the vitamin D compound comprising a vitamin D2, a vitamin D3, an active form of the vitamin D3 or a similar substance, and the active form of the vitamin D3 being 25-hydroxyvitamin D3 or 1,25-dihydroxyvitamin D3.

Description

technical field [0001] The present invention relates to the use of vitamin D compounds in the preparation of medicaments for preventing or treating urinary tract infections. More particularly, it relates to pharmaceutical compositions and pharmaceutical preparations for the prevention or treatment of urinary tract infections. Background technique [0002] Urinary tract infection (UTI) refers to the inflammation caused by pathogens growing and multiplying in the urinary tract and invading the mucosa or tissue of the urinary tract. Bacterial UTI is the most common. Urinary tract infection is a common clinical disease. According to the US outpatient medical survey and hospital outpatient medical survey, there are nearly 7 million outpatient cases and 1 million emergency cases every year, and 100,000 people are hospitalized, especially female patients. A large number of literatures report that the recurrence rate of urinary tract infection is high, about 25-30% of female patien...

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Problems solved by technology

The abuse of antibiotics will lead to the continuous increase of drug-resistant bacteria, and the resistance of bacteria to drugs will increase the amount of antibiotics or continue to seek stronger antibiotics, resulting in economic waste; and its blind bactericidal effect will also lead to the reduction of beneficial bacteria in the body , causing unnecessary harm to the human body

Antibiotics can quickly inhibit the proliferation of bacteria, but they cannot improve the body's own innate immunity. When the pathogen invades again, the innate immunity in the body is still not enough to kill the pathogen, and the infection is easy to recur

The previous article also mentioned the high recurrence rate of UTI. At this stage, antibiotic therapy alone cannot reduce the high recurrence rate of UTI, and it is easy to cause waste of medical resources and heavy economic losses.

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