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Use of orientin

A technology for the use of orientin, which is applied in the field of use of orientin, can solve problems such as recurrent attacks, and achieve the effect of improving bloody stool and good application prospects

Inactive Publication Date: 2015-07-15
SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, sulfasalazine, 5-aminosalicylic acid (5-ASA) sustained-release dosage forms, and corticosteroids are still the main drugs for clinical treatment of ulcers, and patients often need long-term medication maintenance, often recurrent

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0071] The preparation of embodiment 2 tablet

[0072] Utilize conventional technique, mix following component, then directly compress tablet, prepare the pharmaceutical composition of tablet form, its formula is as follows:

[0073]

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Abstract

The invention relates to the technical field of medicine, and especially relates to a use of orientin. The invention discloses the use of orientin, prodrugs and pharmaceutical salts or plant extracts containing orientin in preparation of drugs or health-care products for prevention or treatment of ulcerative colitis. The orientin disclosed for the first time can significantly improve the experimental ulcerative colitis mice bloody stool, shortening of colon, tissue pathological damage and other symptoms, provides a new choice for clinical treatment of ulcerative colitis, and has a good application prospect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of orientin. Background technique [0002] Ulcerative colitis (UC) is a chronic non-specific inflammatory disease of the colon and rectum with unknown etiology. The main symptoms are diarrhea, mucus pus and blood, abdominal pain and tenesmus. Ulcer formation is a common and intractable disease of the digestive tract with pathological characteristics. In severe cases, there may be extraintestinal symptoms such as fever, arthritis, iritis, erythema nodosum, and serious complications such as colon bleeding, perforation, and cancer. The acute fulminant type of this disease has a high mortality rate, and the chronic persistent type is prone to canceration. It is reported that the incidence rate is 5-20 times higher than that of normal people, with an average of 3.5%-7%. The canceration rate of patients is 20% at 10 years, and 40% at 25 years or more, especially those...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/352A61K36/899A61K36/71A61P1/04A61P29/00A23L1/29A23L33/00
Inventor 窦薇王峥涛孙阿宁任改艳张晶晶丁丽丽
Owner SHANGHAI UNIV OF T C M
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