A kind of freeze-dried powder preparation of naproxen sodium for injection and preparation method thereof
A technology of naproxen sodium and freeze-dried powder injection, which is applied in the field of medicine, can solve the problems of poor resolubility, poor turbidity stability, and high insoluble particles, and achieve good product resolubility, good appearance, and quality indicators Improved effect
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Embodiment 1
[0034] Prepare one thousand bottles of the naproxen sodium freeze-dried powder preparation for injection whose solution total amount is 3000g before freeze-drying:
[0035] (1) Accurately weigh 275g of naproxen sodium and 100g of mannitol respectively, and set aside.
[0036] (2) Put the weighed naproxen sodium in the liquid preparation container, add 2000g of water for injection, stir until completely dissolved; then add the weighed mannitol and stir until completely dissolved, add water for injection to 2700g, stir to uniform.
[0037] (3) After the solution is completely dissolved and stirred evenly, measure the pH value, and slowly add an appropriate amount of 1mol / L sodium hydroxide solution to adjust the pH to 9.5.
[0038] (4) Weigh 1.35 g of activated carbon for needles, add it to the solution, and absorb for 30 minutes;
[0039] (5) After absorbing for 30 minutes, use a filter device with a pore size of 0.45 microns to filter and decarbonize, and the filtered medici...
Embodiment 2
[0047] The process is basically the same as in Example 1, except that in steps (3) and (5), the corresponding values of each pH value are 9.65.
Embodiment 3
[0049] The process is basically the same as in Example 1, except that in steps (3) and (5), the corresponding values of each pH value are 9.8.
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