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Penicillin separation and purification method

A technology for separation and purification of penicillin, applied in the field of separation and purification of penicillin, can solve the problems of low production efficiency of penicillin, and achieve high production efficiency and high purity

Inactive Publication Date: 2015-08-12
ZHANGJIAGANG HONGJIA DIGITAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, penicillin has the problem of low production efficiency

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0020] The present invention is further illustrated by the following examples: According to the following examples, the present invention can be better understood. However, those skilled in the art can easily understand that the specific material ratios, process conditions and results described in the examples are only used to illustrate the present invention, and should not and will not limit the present invention described in the claims.

[0021] The separation and purification process for producing penicillin by fermentation method includes:

[0022] Fermentation liquid → pretreatment liquid → plate and frame filtration → filtrate → storage tank → BA extraction → decolorization (2 times) → filtration → BA decolorization liquid → NaOH liquid extraction → butanol azeotropic distillation → filtration → crystal → washing → drying → finished product

[0023] 1) Pretreatment of fermentation broth: Impurities in fermentation broth such as high-priced inorganic ions (Ca, Mg, Fe ion...

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PUM

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Abstract

The invention discloses a penicillin separation and purification method. The method comprises the steps of fermentation liquid pretreatment, filtration, extraction, decoloring, and azeotropic distillation. The penicillin production efficiency is high, and obtained penicillin is highly pure.

Description

technical field [0001] The application belongs to the technical field of penicillin production, in particular to a method for separation and purification of penicillin. Background technique [0002] Penicillin is an important antibiotic with high efficiency, low toxicity and wide clinical application. Its successful development has greatly enhanced the ability of humans to resist bacterial infections and led to the birth of the antibiotic family. Its appearance ushered in a new era in the treatment of diseases with antibiotics. After decades of improvement, penicillin injection and oral penicillin have been able to treat pneumonia, tuberculosis, meningitis, endocarditis, diphtheria, anthrax and other diseases respectively. Following penicillin, antibiotics such as streptomycin, chloramphenicol, oxytetracycline, and tetracycline were continuously produced, which enhanced the ability of humans to treat infectious diseases. [0003] In the prior art, penicillin has the probl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D499/18C07D499/46
CPCC07D499/18C07D499/46
Inventor 张莉莉范佳晨赵维达
Owner ZHANGJIAGANG HONGJIA DIGITAL TECH