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Radix bupleuri dripping pills and preparation method thereof

A technology of Bupleurum and dripping pills, applied in the field of Bupleurum dripping pills and its preparation, which can solve the problems of long heating times and time, difficult aggregation, easy oxidation and deterioration of volatile oil, etc.

Active Publication Date: 2015-08-19
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In addition, Chinese patents have reported a variety of extraction methods for the active components of Bupleurum bupleurum, but for the extraction of the volatile oil of Bupleurum bupleurum, the steam distillation method is still continued. And the time is longer, the volatile oil is easy to oxidize and deteriorate and the yield is low
In addition, the specific gravity of bupleurum volatile oil is close to 1.0, and it is not easy to aggregate when suspended in water. It is difficult to obtain a relatively concentrated volatile oil solution by using traditional molecular distillation methods.

Method used

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  • Radix bupleuri dripping pills and preparation method thereof
  • Radix bupleuri dripping pills and preparation method thereof
  • Radix bupleuri dripping pills and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] Product composition: It mainly contains 3% (mass percentage) of Bupleurum volatile oil, 17.5% (mass percentage) of saikosaponins and 6.25% (mass percentage) of other water-soluble active ingredients.

[0072] Preparation:

[0073] a. First, 1.25kg of Bupleurum bupleuri (broken), add 3 times the amount of water, extract by steam distillation, add appropriate amount of water in the volatile oil extractor, add 12.5ml of rapeseed oil as the enrichment carrier, and steam for 5 hours , get Bupleurum volatile oil.

[0074] b. Concentrate the distilled liquid until the volume ratio of the concentrated liquid to the medicinal material is about 1:1, add 95% ethanol, ethanol settle to an ethanol concentration of 70%, let it stand overnight, take the supernatant after ethanol precipitation, and set aside.

[0075] C. The dregs are then extracted with 70% ethanol, which is 4 times the amount of the medicinal material, for 1 hour. Concentrate the ethanol extract under reduced pres...

Embodiment 2

[0079] Product composition: It mainly contains 4.5% (mass percentage) of Bupleurum volatile oil, 23.33% (mass percentage) of saikosaponins and 10% (mass percentage) of other water-soluble active ingredients.

[0080] Preparation:

[0081] a. First, 1.25kg of Bupleurum bupleuri (broken), add 3 times the amount of water, extract by steam distillation, add appropriate amount of water in the volatile oil extractor, add 12.5ml of rapeseed oil as the enrichment carrier, and steam for 8 hours , get Bupleurum volatile oil.

[0082] b. Concentrate the distilled liquid until the volume ratio of the concentrated liquid to the medicinal material is about 1:1, add 95% ethanol, ethanol settle to an ethanol concentration of 70%, let it stand overnight, take the supernatant after ethanol precipitation, and set aside.

[0083] C. The dregs are then extracted with 70% ethanol, which is 4 times the amount of the medicinal material, for 1 hour. The ethanol extract is concentrated under reduced...

Embodiment 3

[0087] Product composition: It mainly contains 3.3% (mass percentage) of Bupleurum volatile oil, 16.25% (mass percentage) of saikosaponins and 8.75% (mass percentage) of other water-soluble active ingredients.

[0088] Preparation:

[0089] a. First, 1.25kg of Bupleurum bupleuri (broken), add 3 times the amount of water, extract by steam distillation, add appropriate amount of water in the volatile oil extractor, add 12.5ml of rapeseed oil as the enrichment carrier, and steam for 16 hours , get Bupleurum volatile oil.

[0090] b. Concentrate the distilled liquid until the volume ratio of the concentrated liquid to the medicinal material is about 1:1, add 95% ethanol, ethanol settle to an ethanol concentration of 70%, let it stand overnight, take the supernatant after ethanol precipitation, and set aside.

[0091] C. The dregs are then extracted with 70% ethanol, which is 4 times the amount of the medicinal material, for 1 hour. Concentrate the ethanol extract under reduced ...

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Abstract

The invention relates to preparation of a traditional Chinese medicine preparation, particularly to radix bupleuri dripping pills and a preparation method thereof. The preparation method comprises: extracting volatile oil in a radix bupleuri herb through water vapor distillation extraction and enrichment carrier enrichment, carrying out ethanol precipitation on the liquid obtained from the distillation extraction, taking the supernatant, concentrating to obtain an extract, extracting radix bupleuri saponin components with 70% ethanol, and mixing the components to prepare the radix bupleuri dripping pills.

Description

Technical field: [0001] The present invention relates to the preparation of a traditional Chinese medicine preparation, in particular to a Bupleuridrome dripping pill and its preparation method. The liquid was precipitated with alcohol, and the supernatant was concentrated into an extract; the saikosaponins were extracted with 70% ethanol, and the above ingredients were mixed to prepare Bupleurum dripping pills. Background technique: [0002] As a commonly used traditional Chinese medicine, Bupleurum bupleurum has been used for nearly two thousand years in my country. It has the functions of dispersing and reducing fever, soothing the liver and relieving stagnation, and promoting Yang Qi. Dysfunction, uterine prolapse embolism. Modern pharmacological studies have proved that Bupleurum has antipyretic, analgesic, sedative, anti-inflammatory, immune enhancement, liver-protecting and gallbladder-protecting, antibacterial, and antiviral effects. The main components of Bupleuri ...

Claims

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Application Information

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IPC IPC(8): A61K36/233A61K9/20A61P29/00A61P25/20
Inventor 章顺楠杨建会李婷董莉娜张洪坡
Owner TIANJIN TASLY PHARMA CO LTD