Preparation process of kanamycin sulfate for injection

A kind of kanamycin sulfate, the technology of preparation process, is applied in the direction such as the cleaning method of using liquid, the medical preparation containing active ingredient, cleaning method and utensils, can solve the problems such as slow production speed of kanamycin sulfate, reach Improve speed, increase production speed, and avoid performance-impairing effects

Inactive Publication Date: 2015-08-26
CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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  • Abstract
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Problems solved by technology

[0005] The technical problem to be solved by this invention is to provide a kind of preparation technology of kanamycin sulfate for injection, to overcome the slow production speed of kanamycin sulfate for injection caused by the preparation technology of existing kanamycin sulfate for injection The problem

Method used

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Examples

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Embodiment

[0020] The preparation technology of kanamycin sulfate for injection comprises the following steps:

[0021] (1) Extraction of kanamycin sulfate: Dilute the mother liquor and water at a volume ratio of 1:10, add 3 grams of sodium bisulfate or sodium hydrogen phosphate solution with an equivalent concentration until the mother liquor becomes clear, and then add 2 grams of equivalent Concentration of hydrochloric acid or sulfuric acid for acidification treatment, adjust pH = 1, add ethanol solution, the concentration of ethanol solution is 80%, the volume of ethanol solution added is 3 times the volume of hydrochloric acid or sulfuric acid used for acidification, stir while adding, in the solution Separate out the mother liquor, separate out the milky white solution of upper layer, the mother liquor that separates out can be recycled; Add the sodium hydroxide of 2 grams of normal concentration in the milky white solution that separates out, adjust pH to 8.5, leave standstill, fil...

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Abstract

The invention relates to a preparation process of kanamycin sulfate for injection. The preparation process of kanamycin sulfate for injection comprises the following steps of extracting kanamycin sulfate, drying the kanamycin sulfate and preparing kanamycin sulfate powder, cleaning a reagent bottle, soaking the reagent bottle in a hydrochloric acid solution with the concentration of 0.01 mol / L-0.1mol / L, conducting spraying type flushing, drying and sterilization, quantitatively filling the kanamycin sulfate powder into the cleaned reagent bottle, filling nitrogen into the bottle, plugging a pretreated a rubber plug and using an aluminum cap to perform cover stabbing treatment. The problem that the production speed of kanamycin sulfate for injection is lower due to an existing kanamycin sulfate preparation process is solved.

Description

technical field [0001] The invention relates to the field of preparation technology of medical drugs, in particular to a preparation technology of kanamycin sulfate for injection. Background technique [0002] Kanamycin sulfate is a colorless to slightly yellow or yellow-green clear liquid. Aminoglycoside broad-spectrum antibiotics, similar to antibacterial spectrum and neomycin. It is mainly effective against severe infections caused by Gram-negative bacteria such as Escherichia coli, Klebsiella, Proteus, Klebsiella pneumoniae, Enterobacter aerogenes and Shigella, and is also effective against drug-resistant Staphylococcus aureus antibacterial effect. Clinically, it is mainly used for pulmonary infection caused by sensitive bacteria. Urinary tract infection, biliary tract infection, sepsis and abdominal infection, etc., the latter two are often used in combination with other antibacterial agents. It can also be used for Staphylococcus aureus infections that are resistan...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K31/7036A61P31/04B08B3/08B08B3/12B08B3/02
Inventor 廖成斌卢朝成
Owner CHINA CHENGDU ANIMAL HUSBANDRY IND BIOPHARM
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