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A kind of styrene cross-linked polymer particles loaded with fat-soluble sunscreen and preparation method thereof

A technology of cross-linked polymers and sunscreens, which is applied in pharmaceutical formulations, cosmetic preparations, toiletry preparations, etc., to achieve high embedding rate, reduce absorption and irritation, and good biocompatibility

Inactive Publication Date: 2017-08-25
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The object of the present invention is to propose a kind of styrene cross-linked polymer microparticles loaded with fat-soluble sunscreen and its preparation method for the photosensitive and phototoxic effects of chemical sunscreens in sunscreen-containing cosmetics, which are easy to irritate the skin. Reduce the irritation of chemical sunscreens to the skin and play a synergistic effect on the sunscreen effect

Method used

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  • A kind of styrene cross-linked polymer particles loaded with fat-soluble sunscreen and preparation method thereof
  • A kind of styrene cross-linked polymer particles loaded with fat-soluble sunscreen and preparation method thereof
  • A kind of styrene cross-linked polymer particles loaded with fat-soluble sunscreen and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] A styrene crosslinked polymer microparticle loaded with a fat-soluble sunscreen, the raw materials used in the preparation process are calculated in parts by weight, and the composition and content of the raw materials are as follows:

[0041] Surfactant 20.0 parts

[0042] 65 parts of deionized water

[0043] 3 parts fat-soluble sunscreen

[0044] 6 parts styrene

[0045] 0.6 parts of divinylbenzene

[0046] 0.81 parts of initiator;

[0047] Described tensio-active agent is anionic surfactant sodium lauryl sulfate;

[0048] Described fat-soluble sunscreen is ethylhexyl salicylate;

[0049] The initiator is a water-soluble initiator, and the water-soluble initiator is a redox initiation system mixed with potassium persulfate and sodium bisulfite, calculated by mass ratio, wherein potassium persulfate: hydrogen sulfite Sodium is 4:3;

[0050] The concrete steps of its preparation process are as follows:

[0051] (1) First, dissolve 20.0g of surfactant in 65g of d...

Embodiment 2

[0057]A styrene crosslinked polymer microparticle loaded with a fat-soluble sunscreen, the raw materials used in the preparation process are calculated in parts by weight, and the composition and content of the raw materials are as follows:

[0058] Surfactant 12.5 parts

[0059] 65 parts of deionized water

[0060] 3 parts fat-soluble sunscreen

[0061] 6 parts styrene

[0062] 0.6 parts of divinylbenzene

[0063] 0.81 parts of initiator;

[0064] Described tensio-active agent is anionic surfactant sodium lauryl sulfate;

[0065] Described fat-soluble sunscreen is ethylhexyl salicylate;

[0066] The initiator is a water-soluble initiator, and the water-soluble initiator is a redox initiation system mixed with potassium persulfate and sodium bisulfite, calculated by mass ratio, wherein potassium persulfate: hydrogen sulfite Sodium is 4:3;

[0067] The concrete steps of its preparation process are as follows:

[0068] (1) First, dissolve 12.5g of surfactant in 65g of de...

Embodiment 3

[0074] A styrene crosslinked polymer microparticle loaded with a fat-soluble sunscreen, the raw materials used in the preparation process are calculated in parts by weight, and the composition and content of the raw materials are as follows:

[0075] Surfactant 20.0 parts

[0076] 65 parts of deionized water

[0077] 3 parts fat-soluble sunscreen

[0078] 6 parts styrene

[0079] 0.6 parts of divinylbenzene

[0080] 0.81 parts of initiator;

[0081] Described tensio-active agent is anionic surfactant sodium lauryl sulfate;

[0082] Described fat-soluble sunscreen is ethylhexyl salicylate;

[0083] The initiator is a water-soluble initiator, and the water-soluble initiator is a redox initiation system mixed with potassium persulfate and sodium bisulfite, calculated by mass ratio, wherein potassium persulfate: hydrogen sulfite Sodium is 4:3;

[0084] The concrete steps of its preparation process are as follows:

[0085] (1) First, dissolve 20.0g of surfactant in 65g of d...

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Abstract

The invention discloses a styrene cross-linked polymer particle loaded with a fat-soluble sunscreen agent and a preparation method. The styrene cross-linked polymer particle loaded with a fat-soluble sunscreen agent has a core-shell structure, the core is the fat-soluble sunscreen agent, and the shell is It is a styrene cross-linked polymer, its particle size is between 57.8-4747nm at 25℃, and the entrapment rate is between 38.05-62.20%. The preparation method is as follows: dissolving the surfactant in deionized water at room temperature, stirring and dissolving to form the water phase; uniformly mixing the fat-soluble sunscreen agent, styrene and divinylbenzene as the oil phase, and mixing the obtained oil phase and the water phase to form an oil phase. emulsification to obtain an emulsion, then add an initiator, stir at a water bath temperature of 50°C, stop the reaction after 4-6 hours of reaction, and filter through demulsification to obtain styrene cross-linked polymer particles loaded with fat-soluble sunscreen agent. Avoid the direct contact between the fat-soluble sunscreen and the skin, and reduce the skin's absorption and irritation to the fat-soluble sunscreen.

Description

technical field [0001] The invention relates to a microparticle loaded with a fat-soluble sunscreen and a preparation method thereof, in particular to a styrene crosslinked polymer microparticle loaded with a fat-soluble sunscreen and a preparation method thereof. Background technique [0002] Due to environmental pollution, the atmosphere is damaged to varying degrees, and the impact of ultraviolet rays on the skin is becoming more and more serious. According to different wavelengths, ultraviolet rays can be divided into long-wave ultraviolet (UVA), medium-wave ultraviolet (UVB) and short-wave ultraviolet (UVC). The impact of ultraviolet rays on the skin mainly includes the following aspects: (1) skin erythema due to sun exposure; (2) skin darkening due to sun exposure; (3) skin photoaging. Therefore, UV protection of the skin is becoming more and more important. [0003] Effective sunscreen ingredients in sunscreen skin care products currently available on the market mai...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/81A61K8/37A61K8/35A61Q17/04
Inventor 章苏宁王晓会
Owner SHANGHAI INST OF TECH
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