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Medicine composite for treating malignant pleural effusion and preparation method and purpose thereof

A malignant pleural effusion and composition technology, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc., can solve the problems of scattered prescriptions, too many drugs, and unclear main lines, etc., and achieve improvement Clinical symptoms, improvement of quality of life, targeted effects

Active Publication Date: 2015-09-23
花宝金
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the patent document 201010284152.0, the power of warming the yang is also insufficient, and the focus is on the regression of pleural effusion and the reduction of adverse reactions. The prescriptions are scattered, there are too many drugs, and the main line is unclear, so it is difficult to play an effective therapeutic role.
The flaws in the prescription of the above-mentioned patented technology determine that it is difficult to produce good clinical effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0063] Embodiment 1: Preparation 1 of the pharmaceutical composition of the present invention

[0064] 5 parts of American ginseng, 20 parts of Panax notoginseng, 5 parts of Tinglizi, 18 parts of Shiwei, 8 parts of Jiaomu, 40 parts of Xu Changqing, 25 parts of Trichosanthes, 40 parts of Astragalus, 15 parts of Alisma, 8 parts of Atractylodes macrocephala, jujube 3 parts, decocted twice with water, adding 8 and 6 times the amount of water respectively, decocting time for 3 and 1.5 hours respectively, combined decoction, filtered, and concentrated to an extract with a relative density of 1.10 (60°C) , spray-dried to obtain a pharmaceutical composition.

Embodiment 2

[0065] Embodiment 2 Preparation 2 of the pharmaceutical composition of the present invention

[0066] 15 parts of American ginseng, 8 parts of Panax notoginseng, 15 parts of Tinglizi, 6 parts of Shiwei, 6 parts of Jiaomu, 20 parts of Xu Changqing, 20 parts of Trichosanthes, 20 parts of Astragalus, 5 parts of Alisma, 18 parts of Atractylodes macrocephala, jujube 9 parts, decoct 3 times with water, add 10, 6, and 6 times the amount of water respectively, and decoct for 1.5, 1.5, and 2 hours respectively, combine the decoction, filter, and concentrate to a relative density of 1.10 (60°C ) extract, spray-dried to obtain a pharmaceutical composition.

Embodiment 3

[0067] Example 3: Tablets for the treatment of malignant pleural effusions

[0068] Take 10g of American ginseng, 12g of Panax notoginseng, 10g of Tinglizi, 12g of Shiwei, 5g of Jiaomu, 30g of Xu Changqing, 15g of Trichosanthes, 30g of raw Astragalus, 10g of Alisma, 12g of Atractylodes macrocephala, 6g of jujube, decoct 3 times with water, add The amount of water is 8, 6, and 6 times the amount of water respectively, and the decoction time is 2, 1.5, and 1.5 hours respectively. The decoction is combined, filtered, concentrated to an extract with a relative density of 1.10 (60°C), spray-dried, and processed according to etc. Add 30% of microcrystalline cellulose and 45% of lactose by weight of the extract powder by incremental method, mix well, and compress into tablets.

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PUM

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Abstract

The invention provides a medicine composite for treating malignant pleural effusion. The medicine composite is prepared with, by weight, 2-18 parts of American ginseng, 4-30 parts of pseudo-ginseng, 2-18 parts of pepperweed seeds, 3-21 parts of pyrrosia lingua, 2-8 parts of seeds of zanthoxylom bungeanum maxim, 10-50 parts of cynanchum paniculatum, 5-25 parts of snake gourd fruits, 10-50 parts of raw radix astragalis, 2-18 parts of rhizoma alismatis, 3-21 parts of rhizoma atractylodis macrocephalae and 2-12 parts of Chinese dates. All ingredients cooperate with one another, the medicine composite is placed in water for dissolution before drinking and is effective in warming the Yang, smoothing the Qi, communicating the Yang and the Qi, excreting the dampness and tonifying the spleen, and all medicine cooperate to achieve that the Yang is warmed and the effusion is relieved. Clinical tests prove that the medicine composite is capable of effectively treating the malignant pleural effusion.

Description

technical field [0001] The invention relates to a pharmaceutical composition, in particular to a pharmaceutical composition for treating malignant pleural effusion and a preparation method thereof. Background technique [0002] Malignant pleural effusions refer to pleural effusions caused by lung cancer or other malignant tumors involving the pleura or primary pleural tumors. Almost all malignant tumors except primary brain tumors and extremity tumors can cause malignant pleural effusions, among which lung cancer is the most common, breast cancer is the second, and lymphoma is the third, about 5%-10% of malignant pleural effusions No primary tumor foci could be found. [0003] Malignant pleural effusion is one of the common complications of advanced tumors, most of which are the result of disease progression or recurrence. It can also be the first clinical manifestation of cancer patients, seriously affecting the survival time and quality of life of patients. A large amount...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P7/10A61K35/57
Inventor 花宝金施展郑红刚李丛煌鲍艳举刘瑞秦英刚
Owner 花宝金
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