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Preparation method of cream for preventing and treating hypertrophic scar

A technology for hypertrophic scars and creams, which is applied in the direction of non-active ingredient medical preparations, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of poor stability and poor curative effect, and achieve long shelf life and cream formulations. The effect of fine and uniform, simple preparation method

Inactive Publication Date: 2018-10-19
CHANGSHA DARUIQI IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Externally applied drugs have the advantages of being directly applied to the wound surface during use, which is convenient and practical, but the currently produced externally applied drugs have the disadvantages of poor curative effect and poor stability

Method used

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  • Preparation method of cream for preventing and treating hypertrophic scar

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preparation example Construction

[0022] A preparation method of a cream for preventing and treating hypertrophic scars, comprising the following steps:

[0023] S100: Heat the silicone oil, white oil, cetostearyl alcohol and stearic acid to 70-80° C. and mix uniformly, then add Tween 80, and mix uniformly to obtain the first mixture.

[0024] The oxygen solubility of silicone oil is ten times that of plasma and saline, and it is a very strong hydrophobic substance. Therefore, silicone oil can inhibit the proliferation of fibroblasts in scar tissue, promote the separation of necrotic tissue and wound surface, and accelerate the regeneration of epithelial cells. Thereby inhibiting the formation of hypertrophic scars. In addition, silicone oil can not support the growth of bacteria, so it plays an antiseptic role, and plays an important role in extending the shelf life of the cream and improving the stability of the cream. Preferably, the silicone oil is medical grade simethicone.

[0025] The chemical name of...

Embodiment 1

[0050] The raw materials are 230 parts of medical grade simethicone oil, 120 parts of glycerin, 50 parts of medical grade white oil, and 10 parts of cetostearyl alcohol (the mass ratio of cetyl alcohol to stearyl alcohol is 3:7) , 20 parts of Tween 80, 10 parts of stearic acid, 5 parts of carbomer and 555 parts of water.

[0051] The preparation method of the cream for preventing and treating hypertrophic scars is as follows:

[0052] Heat the silicone oil to 75°C under stirring, and the stirring speed is 800rpm; then add white oil and continue stirring for 5 minutes, slowly add cetostearyl alcohol and continue stirring for 10 minutes, then slowly add stearic acid and continue stirring for 20 minutes, and finally Tween 80 was slowly added dropwise and stirring was continued for 30 minutes to obtain the first mixture.

[0053] Soak carbomer in water, heat to 75°C under stirring, stir for 60 minutes to mix evenly, stirring speed is 800rpm, then slowly add glycerin and continue ...

Embodiment 2

[0056] The raw materials are 215 parts of medical grade simethicone oil, 140 parts of glycerin, 60 parts of medical grade white oil, and 8 parts of cetostearyl alcohol (the mass ratio of cetyl alcohol to stearyl alcohol is 7:3) , 22 parts of Tween 80, 8 parts of stearic acid, 7 parts of carbomer and 540 parts of water.

[0057] The preparation method of the cream for preventing and treating hypertrophic scars is as follows:

[0058] Heat the silicone oil to 70°C under stirring, and the stirring speed is 700rpm; then add white oil and continue stirring for 5 minutes, slowly add cetostearyl alcohol and continue stirring for 10 minutes, then slowly add stearic acid and continue stirring for 20 minutes, and finally Tween 80 was slowly added dropwise and stirring was continued for 30 minutes to obtain the first mixture.

[0059] Soak carbomer in water, heat to 70°C under stirring, stir for 60 minutes to mix evenly, stirring speed is 700rpm, then slowly add glycerin and continue st...

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Abstract

The invention discloses a method for preparing a cream for preventing and treating hypertrophic scars, which comprises the following steps: heating silicone oil, white oil, cetostearyl alcohol and stearic acid to 70-80°C and mixing them evenly, and then adding Warm at 80°C and mix evenly to obtain the first mixture; soak carbomer in water, heat to 70-80°C and mix evenly, then add glycerin, after mixing evenly, adjust the pH value to 5.0-7.0 with triethanolamine solution to obtain the first mixture Two mixtures; adding the first mixture into the second mixture, heating to 70-80° C. and mixing evenly. The preparation method is simple, the cost is low, the physical and chemical properties of the prepared cream are stable, the cream is fine and uniform, and the shelf life is long, which can significantly reduce the itching of the affected area during the treatment process, restore the skin to its original color, have no pigmentation, and have no obvious scars, and effectively prevent surgery , burns, scalds and the formation of hypertrophic scars after trauma, and has a good curative effect on the formed hypertrophic scars.

Description

technical field [0001] The invention relates to medicine preparation, in particular to a preparation method of a cream for preventing and treating hypertrophic scars. Background technique [0002] Hypertrophic scars are traces left by wound healing. It is characterized by protruding surface, irregular shape, unevenness, flushing and congestion, firm texture, burning pain and itching. [0003] The current methods for treating scars mainly include surgical treatment, local injection of hormones, local radiotherapy, wearing elastic bandages or elastic sleeves, external application of drugs, and external application of scar stickers. Drugs for external application have the advantage of being directly applied to the wound surface during use, which is convenient and practical. However, the currently produced drugs for external application have the disadvantages of poor curative effect and poor stability. Contents of the invention [0004] Based on this, it is necessary to prov...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/765A61K47/22A61K47/32A61P17/02A61K31/047
Inventor 周天行
Owner CHANGSHA DARUIQI IND
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