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A method and kit for detecting susceptibility to prostate cancer

A prostate cancer, susceptibility technology, applied in biochemical equipment and methods, microbial determination/inspection, etc., can solve the problem of lack of prostate cancer gene detection methods, etc.

Active Publication Date: 2018-02-27
冯宁翰
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Problems solved by technology

[0003] The invention provides a method and kit for detecting the susceptibility of prostate cancer, which solves the technical problem of lack of a prostate cancer gene detection method for the Chinese population

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  • A method and kit for detecting susceptibility to prostate cancer

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Embodiment Construction

[0014] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0015] The application basis of the embodiment of the present invention is mainly: using specific Illumina single nucleotide polymorphism (SNP) microarray (iCOGS) analysis, gene analysis from the peripheral blood DNA of 495 prostate cancer cases and 640 control patients 211155 SNPs were typed. Using the method of meta-analysis, it was found that four 8q24 loci (rs1456315, rs16901979, rs6983267, and rs7843031) were independently and closely related to the risk of prostate cancer in the Chinese population, while other chromosomal regions seemed to have limited effects, and among the Chinese population, in The frequencies of risk alleles at these 4 loci were significantly higher than those in European population. Due to the existenc...

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Abstract

The invention relates to the field of early diagnosis of prostate cancer, and discloses a method and kit for detecting susceptibility to prostate cancer. DNA of peripheral blood of a detected person is extracted, fluorogenic quantitative PCR detection is carried out on SNP loca of rs1456315, rs16901979, rs6983267 and rs7843031 on 8q24 chromosomes of the DNA of the peripheral blood of the detected person, and the genetype of the loca is determined. The genetype is analyzed. The degree of being susceptible to the prostate cancer and the probability of having diseases of the detected person are calculated according to the analysis result of the genetype. The risk of Chinese susceptible to the prostate cancer is mastered, and the detecting accuracy of the susceptibility of Chinese to the prostate cancer is improved.

Description

technical field [0001] The invention relates to the field of early diagnosis of prostate cancer, in particular to a method and kit for detecting susceptibility to prostate cancer. Background technique [0002] Prostate cancer is the most common malignant tumor in men, accounting for the second cause of cancer death in men, accounting for about 40% of all male cancer patients. In recent years, with the aging of the population and the improvement of living conditions, the incidence has increased significantly. Prostate cancer usually grows slowly, and patients often have obvious symptoms or signs after several years of onset. Therefore, timely detection and early treatment are the key to the diagnosis and treatment of prostate cancer. However, the cause of prostate cancer is still unclear. A large number of association studies and epidemiological studies at home and abroad have shown that prostate cancer is closely related to genetic factors. In the prior art, prostate cancer...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6886C12Q1/6851
CPCC12Q1/6851C12Q1/6886C12Q2600/156C12Q2531/113C12Q2561/101
Inventor 冯宁翰吕永杰冯杨焜毛雪莹鲁晓杰张越洲邵宁汪洋温丽婷徐新宇王纯才包文平吴子晨黄锐
Owner 冯宁翰