Omega-3 fatty acid nutraceutical composition and optimization method

A fatty acid, free fatty acid technology, applied in the production of fat, fat oil/fat production, food science, etc., can solve problems such as difficult maintenance

Active Publication Date: 2018-09-11
罗纳德·罗斯代尔 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At colder temperatures, such as those experienced by cold-blooded marine animals, phytoplankton, and also plants, membrane fluidity is generally lower and more difficult than in the environment of a warm-blooded mammal maintain

Method used

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  • Omega-3 fatty acid nutraceutical composition and optimization method
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Embodiment Construction

[0050] figure 1 Indicates the distinction between omega-3 fatty acids (eg EPA) in free fatty acid form, ethyl ester form, triglyceride form, and phospholipid form.

[0051] Here, the chemical structure of EPA (100) in free fatty acid form, which is CH3CH2CH=CHCH2CH=CHCH2CH=CHCH2CH=CHCH2CH=CH(CH2)3COOH, can be abbreviated as R1-COOH(102). Likewise, the chemical structure of EPA in the ethyl ester form can be abbreviated as R1-CO-OCH2CH3 (104).

[0052] EPA in the form of 3-chain glycerol (106), assuming only one of the chains R1 is EPA, and the other two chains can be different fatty acids, often general C16 and C18 fatty acids (R2 and R3) are:

[0053] CH2-O(O)C-R1

[0054] |

[0055] CH-O(O)C-R2

[0056] |

[0057] CH2-O(O)C-R3

[0058] In contrast, the phospholipid form of EPA(108) has the following chemical structure:

[0059] CH2-O(O)C-R1

[0060] |

[0061] CH-O(O)C-R2

[0062] |

[0063] CH2-O(PO3)-X where X can be a side group such as choline, serine or ethanol...

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Abstract

A novel omega-3 fatty acid / lipid based nutritional composition and a method of optimizing said omega-3 fatty acid / lipid based nutritional composition. The nutritional compositions and methods are based on the insight that different forms of high omega-3 fatty acid lipids (eg, triglyceride form, ethyl ester form, free fatty acid form, phospholipid form) have different molecular modes and levels of action. Specifically, the phospholipid form may be more effective in promoting membrane fluidity and permeability, while the free fatty acid form may be more effective in modulating cellular receptors, such as PPARa receptors, which are responsible for different metabolic actions, including fat metabolisim. Favorable conditions for producing omega-3 compositions that can act synergistically and thus more robustly improve health and to some extent mimic markers of life extension such as shown by caloric restriction are taught along with specific optimization methods , markers, and compositions.

Description

technical field [0001] The present invention is in the field of nutraceuticals and nutritional supplements and methods of optimizing nutraceuticals and nutritional supplements. Background technique [0002] Omega-3 fatty acids: [0003] Omega-3 fatty acids, also known as n-3 polyunsaturated fatty acids (PUFA), have been suspected to have beneficial effects in humans, especially for reducing the risk of coronary heart disease, reducing obesity, improving diabetic parameters including blood sugar levels, and improving metabolism Other parameters of the syndrome. These fatty acids have many beneficial effects, one of which is the reduction of elevated blood triglyceride levels to more clinically acceptable values ​​(Harris et al., "Omega-3 Fatty Acids and Coronary Heart Disease Risk: Clinical and Mechanistic "Omega-3 fatty acids and coronary heart disease risk: Clinical and mechanical perspectives" Atherosclerosis. 2008 Mar;197(1):12-24). Omega-3 fatty acids may also help re...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A23L33/115C11B1/00
Inventor 罗纳德·罗斯代尔
Owner 罗纳德·罗斯代尔
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