Headache treating pharmaceutical composition, preparation method and uses thereof

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, active ingredients of hydroxyl compounds, etc., can solve problems such as delayed disease, complex etiology of headache, and no treatment method

Inactive Publication Date: 2015-10-28
TIANJIN INSTITUTE OF PHARMA RESEARCH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0020] The etiology of headache is complicated, and its manifestations are various. Modern medicine treats a certain clinical symptom, but fails to achieve the expected effect, cannot find a suitable treatment method, and often delays the disease. In order to overcome the above defects, the present invention treats headache based on traditional Chinese medicine. Based on the principle of combining syndrome differentiation, treat both symptoms and root causes, both deficiency and excess, regulate internal and external, and take both urgent and urgent measures, and screen out the medicines for promoting blood circulation and promoting Qi, dredging collaterals and relieving pain, and refreshing the mind. prepared

Method used

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  • Headache treating pharmaceutical composition, preparation method and uses thereof
  • Headache treating pharmaceutical composition, preparation method and uses thereof
  • Headache treating pharmaceutical composition, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0074] Weigh 500g of scutellaria, 300g of Chuanxiong, 100g of Angelica dahurica, 100g of Vitex, 2g of artificial musk and 1g of borneol.

[0075] (1) Rhizoma Chuanxiong, Angelica dahurica, Erigeron breviscapus, and Vitex were extracted with 8 times the amount (volume / weight, in ml / g) of 50% ethanol solution under reflux for 2 hours to obtain an ethanol extract, and then 50% ethanol extract Concentrate under reduced pressure at ℃ to form an extract, dry in vacuum at 60 ℃, and pulverize;

[0076] (2) Decoct the dregs with 10 times the amount (volume / weight, in ml / g) of water for 1 hour, filter the boiling liquid, concentrate the filtrate at 60°C under reduced pressure to form an extract, and dry it under vacuum at 60°C;

[0077] (3) Artificial musk and borneol are crushed separately and set aside;

[0078] (4) Combine the above fine powders to obtain.

Embodiment 2

[0080] Weigh 200g of breviscapine, 100g of Chuanxiong, 200g of Angelica dahurica, 20g of Vitex, 5g of artificial musk and 5g of borneol.

[0081] (1) Rhizoma Chuanxiong, Angelica dahurica, Erigeron breviscapus, and Vitex were extracted by refluxing 10 times the amount (volume / weight, in ml / g) of 70% ethanol solution for 2 hours; medicinal residues were extracted by 8 times the amount (volume / weight , in ml / g) of 70% by volume ethanol solution for reflux extraction for 1 hour to obtain an ethanol extract, then concentrate the ethanol extract at 60°C under reduced pressure to form an extract, dry it under vacuum at 50°C, and pulverize;

[0082] (2) Ultrasonic extraction of artificial musk plus 10 times the amount of 95% by volume ethanol solution, filtering the extract to obtain a filtrate, dissolving borneol in the filtrate for later use;

[0083] (3) Take 100g of beta-cyclodextrin, add 1000mL of water, stir at 50°C for 2 hours, add the ethanol solution in step 2, continue to s...

Embodiment 3

[0086] Weigh 50g of breviscapine, 20g of Chuanxiong, 20g of Angelica dahurica, 50g of Vitex, 10g of artificial musk and 10g of borneol.

[0087] (1) Chuanxiong, Angelica dahurica, and Erigeron breviscapus were decocted with 12 times the amount (volume / weight, in ml / g) of water for 2 hours, and the dregs were added with 10 times the amount (volume / weight, in ml / g) of Decoct in water for 1 hour, filter the boiling liquid, concentrate the filtrate under reduced pressure at 70°C to form an extract, dry it under vacuum at 70°C, and pulverize;

[0088] (2) Artificial musk and borneol are crushed separately and set aside;

[0089] (3) Combine the above fine powders to obtain.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and provides a headache treating pharmaceutical composition, a preparation method and uses thereof, wherein the pharmaceutical composition is mainly prepared from the following raw materials by weight: 50-500 parts of Erigeron breviscapus, 20-300 parts of Ligusticum chuanxiong Hort, 20-300 parts of Angelica dahurica, 20-300 parts of fructus viticis, 0.5-10 parts of artificial musk, and 0.5-10 parts of borneol. The pharmaceutical compositions of the present invention has effects of blood circulation activating, qi promoting, collateral dredging, analgesia, resuscitation and refreshing. In addition, various preparations prepared from the pharmaceutical composition can be used for treating headaches, wherein advantages of significant clinical treatment effect, low cost and safe use are provided.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and relates to a pharmaceutical composition and its preparation method and application, in particular to a headache-treating pharmaceutical composition and its preparation method and application. Background technique [0002] Headache is one of the common symptoms clinically, and usually refers to the pain confined to the upper half of the skull, including the brow arch, the upper border of the helix, and the line above the external occipital inion. There are many reasons for headaches, such as: head lesions, internal injuries, long-term insomnia, poor mood, etc. Some of them are serious and fatal diseases. , making the patient suffer. [0003] There are 14 types of headaches, amounting to more than 250 types. [0004] 1. Primary headache [0005] (1) Migraine [0006] (2) Tension-type headache [0007] (3) Cluster headache [0008] (4) Other primary headaches [0009]...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61P29/00A61P25/00A61K31/045A61K35/55
Inventor 马莉韩峰高静
Owner TIANJIN INSTITUTE OF PHARMA RESEARCH
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