Unlock instant, AI-driven research and patent intelligence for your innovation.

A kind of pharmaceutical composition of esomeprazole sodium

A technology of esomeprazole sodium and its composition, which is applied in the field of preparation of pharmaceutical compositions and its preparations and preparations, and can solve problems such as decreased blood calcium, decreased calcium ions, and personal safety impacts

Active Publication Date: 2018-02-23
长春海悦药业股份有限公司
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] However, as we all know, because edetic acid and its salts can combine with calcium ions in the human body to form soluble complexes, which will cause the decrease of calcium ions in the body, lead to a decrease in blood calcium, and affect personal safety. When edetic acid and its salts are used as antioxidants for injections, the management is relatively strict, and the dosage is also strictly controlled

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of pharmaceutical composition of esomeprazole sodium
  • A kind of pharmaceutical composition of esomeprazole sodium
  • A kind of pharmaceutical composition of esomeprazole sodium

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Pharmaceutical composition: 42.5g of esomeprazole sodium, 0.8g of sodium glycinate as an auxiliary material, and 0.2g of sodium chloride as an auxiliary material;

[0081] Preparation method: Weigh sodium hydroxide, add water for injection to dissolve and dilute to make 2% sodium hydroxide solution for later use; take 80% water for injection, add sodium glycinate, dissolve completely, add esomeprazole sodium, and use 2% % sodium hydroxide solution to adjust the pH value to 11.3, add water to the full amount, add sodium chloride, add 0.05% (g / ml) activated carbon for needles, stir and absorb at room temperature for 20 minutes, filter to remove carbon, use 0.45µm filter element and 0.22µm filter, fill and freeze-dry to obtain 1000 preparations respectively.

Embodiment 2

[0083] Pharmaceutical composition: 42.5g of esomeprazole sodium, 0.64g of sodium glycinate as an auxiliary material, and 0.16g of sodium chloride as an auxiliary material;

[0084] Preparation method: Weigh sodium hydroxide, add water for injection to dissolve and dilute to make 2% sodium hydroxide solution for later use; take 80% water for injection, add sodium glycinate, dissolve completely, add esomeprazole sodium, and use 2% % sodium hydroxide solution to adjust the pH value to 11.8, add water to the full amount, add sodium chloride, add 0.05% (g / ml) activated carbon for needles, stir and absorb at room temperature for 20 minutes, filter to remove carbon, use 0.45µm filter element and 0.22µm filter, fill and freeze-dry to obtain 1000 preparations respectively.

Embodiment 3

[0086] Pharmaceutical composition: 42.5g of esomeprazole sodium, 0.96g of sodium glycinate as an auxiliary material, and 0.24g of sodium chloride as an auxiliary material;

[0087] Preparation method: Weigh sodium hydroxide, add water for injection to dissolve and dilute to make 2% sodium hydroxide solution for later use; take 80% water for injection, add sodium glycinate, dissolve completely, add esomeprazole sodium, and use 2% % sodium hydroxide solution to adjust the pH value to 11.5, add water to the full amount, add sodium chloride, add 0.05% (g / ml) activated carbon for needles, stir and absorb at room temperature for 20 minutes, filter to remove carbon, use 0.45µm filter element and 0.22µm filter, fill and freeze-dry to obtain 1000 preparations respectively.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention belongs to the technical field of medicine, and specifically relates to a pharmaceutical composition of esomeprazole sodium, wherein the pharmaceutical composition comprises: esomeprazole sodium and sodium glycinate, or the pharmaceutical composition comprises: esomeprazole sodium sodium azole, sodium glycinate and sodium chloride. Tests show that the pharmaceutical composition of the present invention is prepared into preparations, and the impurity III and impurity V are significantly reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition of esomeprazole sodium, a preparation thereof and a preparation method of the preparation. Background technique [0002] Esomeprazole is the S-isomer of omeprazole, which reduces gastric acid secretion through a specific targeting mechanism and is a specific inhibitor of proton pumps in parietal cells. The site and mechanism of action are that esomeprazole concentrates in the high-acid environment of the acid-secreting microtubules of the parietal cells and converts it into an active form, thereby inhibiting the H at this site. + / K + -ATP (proton pump), inhibits both basal and stimulated gastric acid secretion. [0003] Esomeprazole sodium is the first proton pump inhibitor developed into an isomer. It was developed by AstraZeneca Pharmaceutical Co., Ltd. and was approved by the FDA in March 2005. The dosage form is injection, and the ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/18A61K47/02A61K9/19A61K31/4439
Inventor 韩翠娟王丽娜郝昕
Owner 长春海悦药业股份有限公司