Pain-easing hemostasis medicine and preparation method and application thereof

A technology of drugs and substances, applied in the field of analgesic and hemostatic drugs and their preparation, can solve problems such as paralysis and death, high content of active ingredients for analgesic and hemostatic drugs, and more toxins in the dosage

Inactive Publication Date: 2015-11-04
GUIYANG UNIV
View PDF2 Cites 8 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Although Feilongzhangxue has a good analgesic and hemostatic effect [2] , but to exert analgesic and hemostatic effects, the daily dose should reach about 20-30g, because the blood of Feilongzhang contains more toxic components of alkaloids, such as the chelerythrine contained in it is a neuromuscular toxin, which strongly inhibits the heart Effect, overdose can cause paralysis and death [3] Therefore, to use Fei

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Pain-easing hemostasis medicine and preparation method and application thereof
  • Pain-easing hemostasis medicine and preparation method and application thereof
  • Pain-easing hemostasis medicine and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1 (preparation of analgesic and hemostatic drugs):

[0033] (1) Take 6.0 kg of root or root bark of Toddalia asiatica (L.) Lam., wash, dry, and crush through an 80-mesh sieve;

[0034] (2) Add water and ethanol solution respectively: 10% (v / v), 20% (v / v), 30% (v / v), 40% (v / v), 50% (v / v), 60% (v / v), 70% (v / v), 80% (v / v) and 95% (v / v) reflux extraction 3 times, 1 hour each time, the ratio of solid to liquid is 1 for the first time: 12. The second and third times are 1:10;

[0035] (3) All the extracts were combined, filtered, and the filtrate was distilled under reduced pressure to remove the solvent to obtain 1.2 kg of ethanol extract. Add 2.5 kg of hot water at 60°C to the extract, stir and suspend to obtain a suspension;

[0036] (4) Extract three times with 2 times volume of petroleum ether, chloroform, ethyl acetate and n-butanol in sequence;

[0037] (5) Distill the solvent under reduced pressure respectively to obtain 281 g of chloroform extract, 46...

Embodiment 2

[0041] Embodiment two (this medicine HPLC analysis):

Embodiment 1

[0042] Take the analgesic and hemostatic powder described in Example 1 (passed through a No. 3 sieve) for HPLC analysis.

[0043] (1) Chromatographic conditions

[0044] Columns Diamonsil C 18 (250mm×4.6mm, 5μm)

[0045] Mobile phase A: Acetonitrile B: 0.75% glacial acetic acid in water

[0046] Elution mode Gradient elution

[0047] Flow rate 1.0 mL / min Detection wavelength 320 nm

[0048] Column temperature 25°C Injection volume 20 μL

[0049] The chromatographic run time is 90 minutes, and the gradient elution program is shown in Table 1. The HPLC chromatogram of the analgesic and hemostatic drug of the present invention is shown in the attached figure 1 .

[0050]

[0051] (2) Sample preparation method

[0052] About 0.5g of the extract, accurately weighed, put in a Erlenmeyer flask, add 70% ethanol to ultrasonically dissolve, filter, put the filtrate in a 100 mL measuring bottle, add 70% ethanol to the mark, shake well, filter through a 0.45μm filter m...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to pain-easing hemostasis medicine and a preparation method and application thereof and belongs to the technical field of Chinese herb deep processing. With traditional national herbs (Asiatic toddalia roots) being raw materials, the pain-easing hemostasis medicine is obtained through deep processing, and the preparation method and application of the medicine are provided. Extraction is performed on the Asiatic toddalia roots through water and an ethyl alcohol solution, then yellowish-brown particles are obtained through purification and separation, the content of coumarin chemical substances serving as main components is larger than or equal to 25%, the content of alkaloid substances is smaller than 5%, and the balance is mainly starch substances, saccharide substances, tanned substances, terpene substances and sterol substances. The medicine has good pain-easing and hemostatic effects and can be applied to medicine and preparations meeting modern preparation technologies, pharmacodynamics studies show that the pain-easing effect is comparable to that of aspirins, and the hemostatic effect is close to that of Yunnan white drug powder; the technology is simple and convenient to implement, operation is convenient, industrial production can be achieved, and market prospects are good.

Description

technical field [0001] The invention belongs to the field of deep processing of traditional Chinese medicine, and in particular relates to an analgesic and hemostatic drug obtained by deep processing of the national medicine Feilongzhang blood, a preparation method and application thereof. Background technique [0002] Hemostasis is a complex physiological process, which is mainly affected by important factors such as blood coagulation, platelet aggregation and vasoconstriction. When bleeding occurs due to vascular injury, the tissue's own coagulation mechanism is fully displayed, the activity of prothrombin activator is enhanced, and the formation increases, and then prothrombin is converted into thrombin, which then catalyzes the conversion of fibrinogen into fibrin, and also makes The body produces factors that counteract the fibrinolytic process. All drugs that can stop bleeding are called hemostatic drugs. Hemostatic drugs mainly promote blood coagulation by enhancing ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K36/75A61P7/04A61P29/00A61K125/00
Inventor 刘志刚谢晓林
Owner GUIYANG UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap