Solid lipid sunscreen particles coated with high-concentration sun screener and preparation method of solid lipid sunscreen particles

A solid lipid and sunscreen technology, applied in the field of daily chemistry, can solve the problem of low coating concentration of sunscreen

Inactive Publication Date: 2015-11-11
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the above-mentioned technical problems in the prior art, the present invention provides a solid lipid sunscreen particle coated with a high-concentration sunscreen agent and a preparation method thereof. The solid lipid sunscreen particle coated with a high-concentration sunscreen agent The preparation method thereof solves the problem that the coating concentration of the sunscreen agent in the prior art is not high

Method used

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  • Solid lipid sunscreen particles coated with high-concentration sun screener and preparation method of solid lipid sunscreen particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0128] A solid lipid sunscreen granule coated with a high-concentration sunscreen, calculated according to the total amount of 100g, its composition and content are as follows:

[0129] Solid sunscreen 1g (1%)

[0130] Liquid sunscreen 5g (5%)

[0131] Solid fat 15g (15%)

[0132] Liquid Lipid 3g (3%)

[0133] Solid emulsifier 1g (1%)

[0134] Water-soluble polymer 0.5g (0.5%)

[0135] Additive 0.5g (0.5%)

[0136] Preservatives 0.01g (0.01%)

[0137] The balance is deionized water;

[0138] Described solid sunscreen is butylmethoxydibenzoylmethane;

[0139] The liquid sunscreen is octyl methyl cinnamate;

[0140] Described solid lipid is stearic acid;

[0141] The liquid lipid is caprylic acid / capric triglyceride;

[0142] Described solid emulsifier is C 16 C 18 Alkyl glycosides;

[0143] Described water-soluble polymer is xanthan gum;

[0144] Described additive is sodium chloride;

[0145] The preservative is diazolidinyl urea.

[0146] The above-mentioned p...

Embodiment 2

[0158] A solid lipid sunscreen granule coated with a high-concentration sunscreen, calculated according to the total amount of 100g, its composition and content are as follows:

[0159] Solid sunscreen 10g (10%)

[0160] Liquid sunscreen 25g (25%)

[0161] Solid fat 10g (10%)

[0162] Liquid Lipid 10g (10%)

[0163] Solid emulsifier 7g (7%)

[0164] Water-soluble polymer 0.1g (0.1%)

[0165] Additive 2g (2%)

[0166] Preservative 0.2g (0.2%)

[0167] The balance is deionized water;

[0168] The solid sunscreen is benzophenone-3;

[0169] The liquid sunscreen is octyl salicylate;

[0170] The solid lipid is cetostearyl alcohol;

[0171] Described liquid lipid is isopropyl palmitate;

[0172] Described solid emulsifier is C 22 Alkyl glycosides;

[0173] Described water-soluble polymer is hydroxyethyl cellulose;

[0174] Described additive is potassium chloride;

[0175] Described preservative is phenoxyethanol.

[0176] The preparation method of the above-mentione...

Embodiment 3

[0178] A solid lipid sunscreen granule coated with a high-concentration sunscreen, calculated according to the total amount of 100g, its composition and content are as follows:

[0179] Solid sunscreen 15g (15%)

[0180] Liquid sunscreen 35g (35%)

[0181] Solid lipid 3g (3%)

[0182] Liquid Lipid 2g (2%)

[0183] Solid emulsifier 10g (10%)

[0184] Water-soluble polymer 0.1g (0.1%)

[0185] Additive 10g (10%)

[0186] Preservative 0.5g (0.5%)

[0187] The balance is deionized water;

[0188] Described solid sunscreen is ethylhexyl triazone;

[0189] The liquid sunscreen is 2-cyano-3,3-octyl diphenylacrylate;

[0190] Described solid lipid is glyceryl tristearate;

[0191] The liquid lipid is isooctyl palmitate;

[0192] Described solid emulsifier is ceteareth-25;

[0193] Described water-soluble polymer is carboxymethyl cellulose;

[0194] The additive is 1,3-butanediol;

[0195] The preservative is diazolidinyl urea.

[0196] The preparation method of the above...

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Abstract

The invention provides solid lipid sunscreen particles coated with a high-concentration sun screener. The solid lipid sunscreen particles consist of the following components in percentage by weight: 0-25% of a solid sun screener, 5-60% of a liquid sun screener, 1-20% of solid lipid, 0-10% of liquid lipid, 1-15% of a solid emulsifying agent, 0.01-20% of an additive, 0-0.5% of a water-soluble polymer, 0.01-0.8% of a preservative and the balance of deionized water. The invention also provides a preparation method of the sunscreen particles, and the preparation method comprises the following steps: melting and uniformly dispersing an oil phase consisting of the solid lipid, the liquid lipid, the emulsifying agent and the sun screeners at 50-95 DEG C to obtain an oil phase, and heating a water phase consisting of the water-soluble polymer, the additive and the deionized water to 50-95 DEG C at the same time; homogenizing the water phase, adding the oil phase, uniformly mixing, and then performing ultrasonic or high-pressure homogenization; and finally, stirring to cool to the room temperature. The particle size range of the coated solid lipid sunscreen particles is between 100nm and 5 microns.

Description

technical field [0001] The invention belongs to the field of daily chemistry and relates to a cosmetic, in particular to a solid lipid sunscreen particle coated with a high-concentration sunscreen and a preparation method thereof. Background technique [0002] Solid lipid nanoparticles (SLN), also known as solid liposomes, are solid particles formed by solidification and crystallization of solid fat during cooling or phase separation. As a new type of carrier, solid lipid nanoparticles have the advantages of good physiological compatibility, biodegradability, strong drug loading capacity, stable physical and chemical storage, low cost, and large-scale production. When used in cosmetics, it can enhance the permeability and targeting of active ingredients, improve the closure effect and hydration, and at the same time, as a coating carrier, it can improve the stability of active ingredients. [0003] Sunscreen has always been a topic of concern in the field of cosmetics, and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/14A61K8/11A61K8/73A61K8/92A61Q17/04
Inventor 张婉萍朱海洋贾兵文静
Owner SHANGHAI INST OF TECH
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