A slow-release antibacterial absorbable medical suture and preparation method thereof

A suture, sustained-release technology, applied in the field of medical sutures, can solve the problems of skin tissue inflammation, bacterial infection of wounds, prolong the healing cycle, etc., to increase mechanical strength and cell affinity, increase stability, increase The effect of antibacterial properties

Active Publication Date: 2018-06-01
安徽省康宁医疗用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a foreign body, the suture exists in the incision tissue, and it is easy to cause an inflammatory reaction in the skin tissue. The sutured wound is easily infected by bacteria in the surrounding environment of the body, which will cause the wound to prolong the healing period due to bacterial infection. Therefore, it is necessary to provide a A suture thread with long-acting sustained-release antibacterial effect

Method used

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  • A slow-release antibacterial absorbable medical suture and preparation method thereof
  • A slow-release antibacterial absorbable medical suture and preparation method thereof

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preparation example Construction

[0026] Reference figure 1 The method for preparing a sustained-release antibacterial and absorbable medical suture provided by the present invention includes the following steps:

[0027] S1. Preparation of suture fiber: carboxymethyl chitosan, red sea bream skin collagen, grass carp collagen, pig bone collagen, mannitol, epoxy soybean oil, glycerin, vanillin, genipin, diisopropyl Carbodiimide is mixed, heated to 90-100°C, stirred at a speed of 100-300r / min for 2-3h, extruded with a twin-screw extruder, water-cooled, air-dried, pelletized to obtain a masterbatch; heated to 120- The masterbatch is melted at 140°C, defoamed, and the primary fiber is obtained through the spinneret; the primary fiber is stretched in a water bath at 40-60°C to obtain the suture fiber;

[0028] S2. Preparation of coating solution: adding aldehyde starch and paint to 40-50 parts of water, stirring at a speed of 600-800r / min for 20-30 minutes to obtain a coating solution;

[0029] S3. Coating weaving: Coat...

Embodiment 1

[0032] A sustained-release antibacterial and absorbable medical suture thread. Its raw materials include 80 parts by weight of carboxymethyl chitosan, 15 parts of red sea bream skin collagen, 8 parts of grass carp collagen, 20 parts of pig bone collagen, and 1 part of mannitol. Parts, 3 parts of epoxy soybean oil, 1 part of glycerin, 3 parts of vanillin, 1 part of genipin, 4 parts of diisopropylcarbodiimide, 0.5 part of aldehyde starch, 5 parts of paint;

[0033] Among them, the preparation method of the paint is as follows: adding allicin, Span-80, and Tween-60 into a 1wt% aqueous solution of carboxymethyl chitosan with a mass fraction of 1% by weight, heating to 60°C, and stirring at a speed of 9000r / min for 90s , The emulsion is obtained, wherein the weight ratio of allicin, Span-80, and Tween-60 is 1:0.24:0.12, and the weight-to-volume (g / ml) ratio of allicin and carboxymethyl chitosan aqueous solution is 2:40; adjust the temperature to 15°C, add the emulsion and the 1wt% sod...

Embodiment 2

[0039] A sustained-release antibacterial and absorbable medical suture thread. Its raw materials by weight include: 100 parts of carboxymethyl chitosan, 10 parts of red sea bream skin collagen, 12 parts of grass carp collagen, 10 parts of pig bone collagen, and 3 parts of mannitol. Parts, 1 part of epoxy soybean oil, 3 parts of glycerin, 2 parts of vanillin, 2 parts of genipin, 2 parts of diisopropylcarbodiimide, 1 part of aldehyde starch, 1 part of paint;

[0040] Among them, the preparation method of the paint is as follows: adding allicin, Span-80, and Tween-60 into a 3wt% aqueous solution of carboxymethyl chitosan with a mass fraction of 3wt%, heating to 50°C, and stirring at a speed of 10000r / min for 50s , The emulsion is obtained, wherein the weight ratio of allicin, Span-80, and Tween-60 is 2:0.12:0.24, and the weight-volume (g / ml) ratio of allicin and carboxymethyl chitosan aqueous solution is 1:60; adjust the temperature to 10°C, add the emulsion and the 3wt% sodium algi...

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Abstract

The invention discloses a slow-release antibacterial and absorbable medical suture. The raw materials include: 80-100 parts of carboxymethyl chitosan, 10-15 parts of red sea bream skin collagen, and 8-12 parts of grass carp collagen. , 10‑20 parts of pig bone collagen, 1‑3 parts of mannitol, 1‑3 parts of epoxidized soybean oil, 1‑3 parts of glycerin, 2‑3 parts of vanillin, 1‑2 parts of genipin, diisopropyl 2‑4 parts of carbodiimide, 0.5‑1 part of aldylated starch, and 1‑5 parts of paint. The invention also discloses a preparation method of the slow-release antibacterial absorbable medical suture, which includes the following steps: S1, preparing suture fiber; S2, preparing a coating solution; S3, coating weaving. The invention has good antibacterial performance, long-term antibacterial ability, good compatibility with biological tissues, easy adhesion and reproduction of cells on the invention, simple operation, less environmental pollution, and is beneficial to industrial production.

Description

Technical field [0001] The invention relates to the technical field of medical sutures, in particular to a sustained-release antibacterial and absorbable medical sutures and a preparation method thereof. Background technique [0002] Surgical suture thread refers to a special thread used for wound ligation, suture hemostasis and tissue suture in surgical operations. According to its biodegradability, it can be divided into two categories: non-absorbable thread and absorbable thread. Absorbable sutures include natural fibers and synthetic polymer sutures. [0003] Chitosan is a natural fiber suture with good biocompatibility, antibacterial ability, chemical inertness, no foreign body reaction to tissues, etc. It can be absorbed by the human body, accelerates wound healing, and is not easy to cause irritation, allergies, Inflammation, and has the advantages of anti-inflammatory, promoting wound healing, and smooth wound after healing, but chitosan has poor mechanical properties and...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L17/10A61L17/08A61L17/14D01F8/18D01F8/02D01F1/10
Inventor 祁建兵
Owner 安徽省康宁医疗用品有限公司
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