Method for calculating eyeball shape, eye axis, and curvature of experiment animal by employing in-vitro measurement

A technology for experimental animals and isolated eyeballs, applied to measuring devices, instruments, and optical devices, etc., can solve problems that have not been reported, increase accuracy and reliability, increase precision, and ensure objectivity and accuracy Effect

Active Publication Date: 2015-11-18
JINSHAN HOSPITAL FUDAN UNIV
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Problems solved by technology

[0005] To sum up, the method of measuring the eye position and eyeball shape of experimental animals needs to be improved urgently, but there is no report on the method of measuring the eye position and eyeball shape of experimental animals with fixed measurement position and digital simulation

Method used

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  • Method for calculating eyeball shape, eye axis, and curvature of experiment animal by employing in-vitro measurement
  • Method for calculating eyeball shape, eye axis, and curvature of experiment animal by employing in-vitro measurement
  • Method for calculating eyeball shape, eye axis, and curvature of experiment animal by employing in-vitro measurement

Examples

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Embodiment

[0040] Example: Studying the morphological changes of guinea pig eyeballs by fitting curves.

[0041] attached Figure 4 Shown in 8 weeks old and 3 weeks old guinea pig isolated eye morphology comparison. Figure A is the result of circle fitting on the side of the cornea of ​​the 8-week-old guinea pig, and its radius of curvature can be observed. Figure B is the fitting curve equation after the fitting of Figure A, rotated by the difference angle and moved to the same position as that of the 3-week-old guinea pig The curve fitting curve on the side of the eyeball cornea has the same circle center, and the change of the corneal curvature radius of the 8-week-old guinea pig and the 3-week-old guinea pig can be clearly compared from the picture B: the curvature radius of the cornea of ​​the 8-week-old guinea pig is larger than that of the 3-week-old guinea pig . Figure C is the fitting result of the scleral conic curve at the posterior pole of the eyeball of the 8-week-old guin...

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Abstract

The invention relates to a method for calculating the eyeball shape, eye axis, and curvature of an experiment animal by employing in-vitro measurement. Fixed position shooting of an in-vitro eyeball is performed by employing an optical apparatus, and the eyeball shape, the eye axis, and the curvature of the experiment animal are calculated via a digital simulation method. The method is advantageous in that optical measurement is employed, the contour of the eyeball is measured in a non-contact manner via a macro shooting device, and then corresponding pixel conversion is performed for measurement so that the accuracy of results is greatly improved, and tiny change of the structure of the eyeball can be discovered and observed; the eyeball of a guinea pig is simulated to an inclined oval with a clear mathematical equation, and the corresponding angles are calculated via analytic geometry and the trigonometric function principle in mathematics so that the accuracy of the results is greatly improved; besides, the results are all obtained by calculation so that the objectivity of the results is greatly guaranteed, and basis is provided for the analysis of the structures of the eyeballs of the guinea pigs in different experiment groups.

Description

【Technical field】 [0001] The invention relates to the technical field of biological parameter measurement for basic ophthalmology research, in particular to a method for measuring and calculating the eyeball shape, eye axis and curvature of experimental animals in vitro. 【Background technique】 [0002] Modern life science research requires that the results of animal experiments be accurate, reliable, repeatable and comparable, that is, different people can get exactly the same experimental results when doing the same animal experiments at different times and in different spaces. This requires us to choose standardized experimental animals and conduct experiments under standard conditions. Guinea pigs, as a good experimental animal, have been studied more and more in experimental myopia models and retinal physiology. Therefore, the measurement of guinea pig eye position and eyeball shape has gradually become an important part of experimental myopia models and retinal physiolo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01B11/24G01B11/255G01B11/02
Inventor 邸悦陆娜罗秀梅刘睿李炳周晓东
Owner JINSHAN HOSPITAL FUDAN UNIV
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