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A porous se‑sio 2 Nanoparticles and their preparation methods and applications

A nanoparticle, se-sio2 technology, applied in pharmaceutical formulations, sulfur/selenium/tellurium active ingredients, medical preparations with non-active ingredients, etc. multifunctional effect

Active Publication Date: 2017-12-29
SHANGHAI UNIV OF ENG SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the nano-selenium products synthesized by the existing nano-selenium preparation methods cannot effectively control the release of selenium, and the function is relatively single, so it is necessary to continue to explore the synthesis of nano-selenium products, which can truly realize the controlled release and multi-function of nano-selenium change

Method used

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  • A porous se‑sio <sub>2</sub> Nanoparticles and their preparation methods and applications
  • A porous se‑sio <sub>2</sub> Nanoparticles and their preparation methods and applications
  • A porous se‑sio <sub>2</sub> Nanoparticles and their preparation methods and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] (1) Cu 2-x Synthesis of Se: Place 49mg cuprous chloride in a three-necked flask, add 10mL oleic acid to form A solution, place 79mg selenium powder in another three-necked flask, add 5mL oleic acid and 5mL oleylamine to form B solution . Put two three-necked flasks into the heating mantle, pour in nitrogen, stir, heat to 120°C, keep it for 20 minutes to remove the moisture and oxygen in the device. Then the B solution was heated to 280°C, kept for half an hour, and then cooled to 220°C. At the same time, the A solution was heated to 220°C. Use a syringe to draw 5 mL of B solution and inject it into 10 mL of A solution. After reacting for 5 minutes, cool to room temperature. Add appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes. After washing three times with ethanol, add 10mL n-hexane to obtain Cu 2-x Se n-hexane dispersion, spare;

[0031] (2) Take 5 mL of Cu prepared in step (1) 2-x Add the Se n-hexane dispersion to the reaction flask...

Embodiment 2

[0034] (1) Cu 2-x Synthesis of Se: Place 49mg cuprous chloride in a three-necked flask, add 10mL oleic acid to form A solution, place 79mg selenium powder in another three-necked flask, add 5mL oleic acid and 5mL oleylamine to form B solution . Put two three-necked flasks into the heating mantle, pour in nitrogen, stir, heat to 120°C, keep it for 20 minutes to remove moisture and oxygen in the device. Then the B solution was heated to 280°C, kept for half an hour, and then cooled to 220°C. At the same time, the A solution was heated to 220°C. Use a syringe to draw 5 mL of B solution and inject it into 10 mL of A solution. After reacting for 5 minutes, cool to room temperature. Add appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes. After washing three times with ethanol, add 10mL n-hexane to obtain Cu 2-x Se n-hexane dispersion, spare;

[0035] (2) Take 5mL (1) Cu prepared 2-x Add Se n-hexane dispersion into the reaction flask, then add 0.9mL d...

Embodiment 3

[0039] A porous Se-SiO 2 Nanoparticles, including elemental Se and SiO coated with elemental Se 2 And coated in SiO 2 The preparation method of polyvinylpyrrolidone on the surface includes the following steps:

[0040] (1) Nano Cu 2-x Synthesis of Se: Place 49mg of cuprous chloride in a three-necked flask, add 10mL of oleic acid to form a solution A, place 79mg of selenium powder in another three-necked flask, add 5mL of oleic acid and 5mL of oleylamine to form a solution B . Put two three-necked flasks into the heating mantle, pour in nitrogen, stir, heat to 120℃, keep for 20 minutes, then heat the B solution to 280℃, keep it for half an hour, then cool it to 220℃, at the same time, The A solution was heated to 220°C. Pipette 5mL solution B into 10mL solution A, react for 5 minutes, then cool to room temperature, add an appropriate amount of absolute ethanol and centrifuge at 12000r / min for 12 minutes, wash the centrifuged product three times with ethanol, and add n-hexane to o...

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Abstract

The invention relates to a porous Se-SiO2 nanoparticle as well as a preparation method and application thereof. The porous Se-SiO2 nanoparticle consists of elementary Se, SiO2 covering the elementary Se and polyvinylpyrrolidone covering the surface of the SiO2; the preparation method comprises the following steps: firstly preparing a Cu2-xSe normal hexane dispersion liquid, and then adding de-ionized water, n-hexanol, polyethylene glycol octylphenol ether, n-hexane, tetraethyl orthosilicate and ammonia water to the Cu2-xSe normal hexane dispersion liquid; dispersing a reaction product in the de-ionized water so as to obtain a nano Se-SiO2 dispersion liquid, then adding polyvinylpyrrolidone to the nano Se-SiO2 dispersion liquid and conducting hydrothermal treatment for a certain duration so as to obtain the porous Se-SiO2 nanoparticle; and the prepared porous Se-SiO2 nanoparticle can be applied to the loading, transfer or slow release of anti-cancer drugs. Compared with the prior art, the porous Se-SiO2 nanoparticle disclosed by the invention has the advantages of good biocompatibility, good nano Se release performance, high anti-cancer drug loading rate and the like.

Description

Technical field [0001] The invention relates to a nano particle and a preparation method and application thereof, in particular to a porous Se-SiO 2 Nano particles and their preparation methods and applications. Background technique [0002] Selenium is one of the essential trace elements for the human body. Studies have shown that the lack of selenium in the human body can easily lead to more than forty diseases, such as cancer, heart disease, diabetes, hypertension and metabolism and hepatitis. Appropriate intake of selenium can enhance the body's immunity and delay biological aging. However, the safety limit between the optimal concentration and the toxic concentration of selenium is very narrow. Therefore, the development of a low-toxic and high-efficiency selenium source is very important for human health. Compared with selenium in other states, the small size effect of nano-selenium particles makes them have optoelectronic properties that conventional bulk selenium materia...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/32A61K47/04A61K47/02A61K33/04A61P35/00
Inventor 刘锡建陆杰孙彦刚张丽娟张红徐菁利
Owner SHANGHAI UNIV OF ENG SCI
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