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High-producing 3-hydroxypropionaldehyde strain and application thereof to prevention and treatment of oral cavity infection of mammals

A high-yield and strain-based technology of hydroxypropionaldehyde, applied in the direction of microorganism-based methods, medical preparations containing active ingredients, bacteria, etc., can solve problems such as gastrointestinal dysfunction, elevated transaminases, and decreased platelets, and shorten the growth cycle , broad-spectrum antibacterial effect, and the effect of reducing production costs

Inactive Publication Date: 2015-11-25
吴前进
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Commonly used antibacterial drugs have achieved certain therapeutic effects in clinical practice, but there are also many side effects, which can cause gastrointestinal dysfunction, leukocytes, thrombocytopenia, and transaminase elevation, etc.

Method used

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  • High-producing 3-hydroxypropionaldehyde strain and application thereof to prevention and treatment of oral cavity infection of mammals
  • High-producing 3-hydroxypropionaldehyde strain and application thereof to prevention and treatment of oral cavity infection of mammals
  • High-producing 3-hydroxypropionaldehyde strain and application thereof to prevention and treatment of oral cavity infection of mammals

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Embodiment 1

[0036] The method for the production of 3-hydroxypropanal of the probiotic high-yield bacterial strain among the present invention, carries out according to the following steps:

[0037] 1. Preparation medium: peptone 10g, beef extract 10g, glucose 20g, yeast extract 5g, Tween 801ml, dipotassium hydrogen phosphate 2g, triammonium citrate 2g, sodium acetate 5g, magnesium sulfate 0.5g, manganese sulfate 0.2g , L-cysteine ​​0.5g, sodium thioglycolate 0.05g, VB120.005g, glycerol 3.68g add water to 1L, adjust the pH value to 6.8;

[0038] 2. Insert Lactobacillus reuteri RS01 of the present invention into the culture medium prepared in step 1, and perform anaerobic fermentation at 37°C for 5h;

[0039] 3. Separation: The plate and frame separation is used for the first separation, and the collected bacteria are fast and not easy to cause the death of the bacteria; then the separated bacteria are inserted into a new medium, and the dissolved oxygen is 0 at 37 ° C. , cultivated for 4...

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Abstract

The invention discloses a high-producing 3-hydroxypropionaldehyde strain and application thereof to prevention and treatment of oral cavity infection of mammals, and relates to a microorganism and a composition thereof, in particular to a microorganism and a composition thereof for prevention and treatment of oral cavity infection of the mammals. Further, the invention aims to provide lactobacillus reuteri short in growth cycle and high in probiotics and application of the lactobacillus reuteri to prevention and treatment of oral cavity infection of the mammals. The high-producing 3-hydroxypropionaldehyde strain refers to the lactobacillus reuteri RS01 and is preserved with the preservation number CGMCC No.9971 in China General Microbiological Culture Collection Center on November 14th, 2014. The high-producing 3-hydroxypropionaldehyde strain has the advantages that the high-producing 3-hydroxypropionaldehyde strain is cultured easily and high in target product yield, and fermentation liquor of the high-producing 3-hydroxypropionaldehyde strain is safe and free of toxic and side effects and has broad-spectrum antibacterial effect. The high-producing 3-hydroxypropionaldehyde strain is applied to the field of prevention and treatment of oral cavity infection of the mammals.

Description

technical field [0001] The invention relates to a microorganism and its composition, in particular to a microorganism and its composition for preventing and treating mammalian oral infection. Background technique [0002] Prebiotic 3-hydroxypropionaldehyde (3-HPA), CAS: 2134-29-4, molecular formula C 3 h 6 o 2 , Soluble in ethanol, ether, acetone, easily soluble in water, easy to polymerize, belonging to aldol compounds, relatively active in nature, no peculiar smell. The prebiotic 3-hydroxypropionaldehyde mainly presents three states of 3-hydroxypropionaldehyde monomer, hydrate and cyclized dimer in aqueous solution. 3-Hydroxypropionaldehyde has aldehyde groups and hydroxyl groups, and it is easy to undergo reactions related to hydroxyl groups and aldehyde groups, and is easy to condense. [0003] The probiotic 3-hydroxypropionaldehyde can be produced by the metabolism of glycerol by bacteria colonized in the intestinal tract of humans and animals. It has a wide range o...

Claims

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Application Information

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IPC IPC(8): C12N1/20C12P7/24A61K35/747A61P1/02A61P31/04A61P31/10C12R1/225
Inventor 吴前进
Owner 吴前进
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