A rapid evaluation method for the tackiness of butyl rubber stoppers

Abstract

The invention relates to a method for quickly evaluating the stickiness of butyl rubber stoppers, specifically: pretreating butyl rubber stoppers with 0.3% NaOH solution, taking butyl rubber stoppers, counting the sample size N of the rubber stoppers, and placing In the aluminum-plastic composite film packaging bag, shake gently to make the rubber stoppers as tight as possible, then vacuum heat seal on the vacuum packaging machine, and the vacuum pressure is 0.09Mpa. The encapsulated butyl rubber stoppers were placed in a constant temperature and humidity incubator with a set temperature of 65°C and a humidity of 70%. After 5 days, take out the packaging bag, cool to room temperature, open the bag to observe the stickiness of the rubber stopper, evaluate the stickiness level of the butyl rubber stopper by the number S of butyl rubber stoppers agglomerated 4 hours after opening the bag, and define the agglomerated individual as the opened bag A number of butyl rubber plugs that are naturally bonded together without being affected by external force factors. The invention quantifies the evaluation results and proposes a specific judging method, which can quickly and effectively evaluate the stickiness of the butyl rubber stopper.

Description

technical field [0001] The invention relates to a method for quickly evaluating the stickiness performance of butyl rubber plugs, belonging to the field of rubber materials. Background technique [0002] At present, drug safety has become a major social issue of concern to the whole people. Butyl rubber stoppers (hereinafter referred to as rubber stoppers) are a type of drug packaging material that directly contacts drugs. [0003] When pharmaceutical manufacturers use rubber stoppers, the rubber stoppers often stick to each other and agglomerate after sterilization and cooling, which leads to the inability of the rubber stoppers to move smoothly, which brings inconvenience to the production of pharmaceutical factories and affects the quality of medicines. We call this phenomenon the stickiness of the rubber stopper. The causes of sticky rubber stoppers include formula design defects, rubber stopper structure design defects, production process fluctuations, improper use of ...

AI Technical Summary

Problems solved by technology

Some enterprises take the method of packing rubber plugs into boxes and stacking them under a long-term load to observe the stickiness. However, this method usually takes 30 days, and the evaluation time is low, so it is impossible to quickly evaluate the stickiness of rubber plugs.

In addition, the stickiness performance of the rubber stopper can be predicted by pinching the feel and resilience of the rubber stopper after vulcanization. Although this method is fast, the accuracy is not high, and the stickiness index cannot be quantified

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