Squamous cell carcinoma antigen measurement system

A squamous cell carcinoma and assay system technology, applied in the field of squamous cell carcinoma antigen assay system, can solve problems such as low accuracy, low sensitivity, and short half-life

Inactive Publication Date: 2015-12-09
田峰
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the ELISA method has its limitations, such as poor specificity, low sensitivity, low accuracy, etc.
Although radioimmunoassay is considered to be an accurate and reliable method, the radiation effects of radioactive isotopes, the need for specialized laboratories for waste disposal, the disadvantages of high cost and short half-life have made this method gradually eliminated.

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  • Squamous cell carcinoma antigen measurement system
  • Squamous cell carcinoma antigen measurement system
  • Squamous cell carcinoma antigen measurement system

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Embodiment Construction

[0024] In order to make the above objects, features and advantages of the present invention more comprehensible, specific implementations of the present invention will be described in detail below in conjunction with the accompanying drawings. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. However, the present invention can be implemented in many other ways different from those described here, and those skilled in the art can make similar improvements without departing from the connotation of the present invention, so the present invention is not limited by the specific implementations disclosed below.

[0025] One embodiment of the squamous cell carcinoma antigen assay system includes magnetic beads coated with anti-fluorescein isothiocyanate antibody, fluorescein isothiocyanate-labeled squamous cell carcinoma antigen antibody, N-(aminobutyl) -N-(isoluminol) labeled squamous cell car...

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Abstract

The invention relates to a squamous cell carcinoma antigen measurement system, which includes magnetic beads coated by an anti-fluorescein isothiocyanate antibody, a squamous cell carcinoma antigen antibody marked by the fluorescein isothiocyanate, a squamous cell carcinoma antigen antibody marked by N-(aminobutyl)-N-(isoluminol), a chemical luminescent substrate and a fluorescent detection device. The squamous cell carcinoma antigen antibody marked by the fluorescein isothiocyanate, the squamous cell carcinoma antigen antibody marked by the N-(aminobutyl)-N-(isoluminol) and a to-be-test substance form a bis-antibody sandwich composite. The magnetic beads coated by the anti-fluorescein isothiocyanate antibody is used for being combined with the bis-antibody sandwich composite to form an antigen antibody composite precipitate which is subjected to a fluorescent reaction with the chemical luminescent substrate. The fluorescent detection device is used for detecting fluorescent intensity of the fluorescent reaction. The squamous cell carcinoma antigen measurement system does not contain any radioactive substances, is high in sensitivity, is good in specificity and is high in accuracy.

Description

technical field [0001] The invention relates to a squamous cell carcinoma antigen assay system. Background technique [0002] Squamous cell carcinoma antigen (SCCa), a glycoprotein with a molecular weight range of 45-55 kDa isoforms, was first proposed by Kato and Torigoe in 1997 as a tumor-associated antigen. SCCa is normally expressed in skin and other squamous epithelial cells and has been shown to be helpful in the diagnosis of lung cancer, especially squamous cell carcinoma. [0003] High concentrations of SCCa have been reported to be detectable in human head and neck, liver and other epithelial cancer tissues. It has also been reported in the literature that SCCa is overexpressed in the serum, oral cavity, lung, skin, head, neck, esophagus, anal canal and vulva of various cervical cancer patients. For example, SCCA levels were increased by 72% in the serum of patients with cervical cancer and 94% in the serum of patients with squamous cell carcinoma of the lung. De...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57484
Inventor 田峰齐素文
Owner 田峰
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