A kind of super linear degradable polymer hydrogel and preparation method thereof
A technology for degrading polymers and hydrogels, applied in the field of superlinear degradable polymer hydrogels and their preparation, can solve the problems of complexity, degradability and gel properties are not easily regulated, molecular hydrogels are not easily degraded, and the like, Achieving the effect of high biocompatibility, rich types, and increased controlled release properties
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Embodiment 1
[0032] The reactor with an air condensing reflux device was purged with high-purity argon. Weigh 100g of double-ended hydroxyl polyethylene glycol with a number average molecular weight of 2000, 130g of caprolactone, 50g of glycolide, 1g of zinc isooctanoate, and 1g of stannous octoate into the reactor; the reaction system is heated to 150°C, React for 30 hours; measure 300 mL of anhydrous and anaerobic-treated toluene into the reactor, stir well; add 0.03976 mol of toluene diisocyanate, 0.00542 mol of 3-isocyanato-3,5,5-tri Methylcyclohexyl isocyanate, 0.0033mol hexamethylene diisocyanate, and then react at 60°C for 6h, 80°C for 6h, and 100°C for 5h; after the above reaction system is cooled to 60°C, add 400mL of petroleum ether to it, shake and remove the upper layer liquid; then add 200mL of petroleum ether, shake to remove the upper liquid; dry the above product under vacuum conditions of 5Pa and temperature of 100°C for 15h; , cooling and other methods to prepare a super...
Embodiment 2
[0034] The reactor with air condensing reflux was purged with high-purity nitrogen. Weigh 100g of double-terminated hydroxyl polyethylene glycol with a number average molecular weight of 1000, 100g of caprolactone, and 2g of zinc isooctanoate and add them to the reactor; raise the temperature of the reaction system to 130°C and react for 20h; measure anhydrous and anaerobic treatment Add 200mL of toluene into the reactor and stir well; after the reaction system is cooled to 60°C, add 0.09mol hexamethylene diisocyanate, then react at 60°C for 6h, 80°C for 6h, and 100°C for 5h; the above reaction system is cooled to 60°C After ℃, add 300mL of petroleum ether to it, and remove the upper liquid after shaking; then add 100mL of petroleum ether, remove the upper liquid after shaking; dry the above product for 20h under a vacuum condition of 10Pa and a temperature of 80°C; add 0.8L of deionized water, by heating, shaking, cooling and other methods to prepare the aqueous solution of s...
Embodiment 3
[0036] The reactor with an air condensing reflux device was purged with high-purity argon. Weigh 100g of double-terminated hydroxyl polyethylene glycol with a number average molecular weight of 1600, 150g of caprolactone, and 2g of stannous octoate into the reactor; raise the temperature of the reaction system to 130°C and react for 24 hours; measure anhydrous and anaerobic treatment Add 250mL of toluene into the reactor and stir well; add 0.06035mol hexamethylene diisocyanate after the reaction system is cooled to 60°C, then react at 60°C for 6h, 80°C for 6h, and 100°C for 5h; the above reaction system is cooled to 40°C Finally, add 300mL of petroleum ether to it, and remove the upper liquid after shaking; then add 100mL of petroleum ether, remove the upper liquid after shaking; dry the above product for 30h under a vacuum condition of 100Pa and a temperature of 90°C; add 2L Physiological saline, prepare a solution of super-linear degradable polymer by heating, shaking, cooli...
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