Cream preparation for preventing and treating joint diseases and preparation method thereof

A joint disease and cream technology, applied in the field of pharmacy, can solve the problems of first-pass effect gastrointestinal tract, adverse reactions, dysphagia, etc., to reduce the incidence of side effects, avoid gastrointestinal irritation, maintain blood flow effect of concentration

Active Publication Date: 2015-12-30
ZHEJIANG CANDORLY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Glucosamine sulfate, the chemical name is bis[D-(+)-2-deoxy-2-aminoglucopyranose] sulfate dipotassium chloride, the existing dosage form is capsules, the price is expensive, and it is administered 3 times a day
Take 2 capsules (314mg) each time for continuous medication for 6 weeks or more. Due to the single dosage form of glucosamine sulfate, most of the glucosamine sulfate preparations currently av

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A cream for preventing and treating joint diseases, the cream includes active ingredients and pharmaceutically acceptable auxiliary ingredients, the active ingredients are glucosamine, chondroitin sulfate sodium and hyaluronic acid, and the ingredients in the cream take up The weight percentage content is: glucosamine 3.5%, sodium chondroitin sulfate 3.0%, hyaluronic acid 2.0%, glycerin 12%, cyclopentasiloxane 3.0%, cetearyl glucoside 2.5% , PEG-100 stearate 2.0%, ammonium acryloyldimethyl taurate / VP copolymer 1.5%, xanthan gum 1.5%, disodium EDTA 3.5%, sage essential oil 1.0%, the balance is water .

[0024] The preparation method of above-mentioned cream, comprises the steps:

[0025] (1) Glucosamine, sodium chondroitin sulfate, and hyaluronic acid are weighed and dissolved in part of glycerin;

[0026] (2) Cyclopentasiloxane, cetearyl glucoside, PEG-100 stearate, ammonium acryloyldimethyltaurate / VP copolymer, xanthan gum, EDTA Sodium and clary sage essential oil a...

Embodiment 2

[0042] A cream for preventing and treating joint diseases, the cream includes active ingredients and auxiliary ingredients, the active ingredients are glucosamine, chondroitin sulfate sodium and hyaluronic acid, the weight percentage of each composition in the cream The content is: Glucosamine 3.8%, Sodium Chondroitin Sulfate 3.5%, Hyaluronic Acid 1.5%, Glycerin 10%, Cetyl Alcohol 2.5%, Shea Butter 2.0%, Polydimethylsiloxane 1.5%, Dimethicone Alcohol 2.0%, Caprylic / Capric Triglyceride 1.5%, Diisostearyl Malate 1.2%, Tocopheryl Acetate 1.0%, Dipotassium Glycyrrhizinate 0.8%, Ginger Root Oil 0.5%, the balance is water .

[0043] The preparation method of above-mentioned cream, comprises the steps:

[0044] (1) Glucosamine, sodium chondroitin sulfate, and hyaluronic acid are weighed and dissolved in part of glycerin;

[0045] (2) Cetyl Alcohol, Shea Butter, Dimethicone, Butylene Glycol, Caprylic / Capric Triglyceride, Diisostearyl Malate, Tocopheryl Acetate, Glycyrrhizic Acid Di...

Embodiment 3

[0053] A cream for preventing and treating joint diseases, the cream includes active ingredients and auxiliary ingredients, the active ingredients are glucosamine, chondroitin sulfate sodium and hyaluronic acid, the weight percentage of each composition in the cream The content is: glucosamine 3.0%, sodium chondroitin sulfate 2.5%, hyaluronic acid 1.0%, glycerin 10%, stearyl alcohol 2.5%, hydrogenated polyisobutene 2.0%, cetearyl glucoside 1.5%, glycerin stearyl Ester 2.0%, vanillyl butyl ether 1.5%, potassium cetyl phosphate 1.0%, iodopropynyl butyl carbamate 0.4%, ginger root oil 0.5%, and the balance is water.

[0054] Efficacy test:

[0055] Get the medicine of the present invention in an appropriate amount and directly smear the affected part, 3 to 5 times a day, and the curative effect statistics for treating rheumatoid arthritis are as shown in Table 3:

[0056] table 3

[0057]

[0058] Medicated to 360 patients with rheumatoid arthritis, including 152 male...

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PUM

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Abstract

The invention relates to a cream preparation for preventing and treating joint diseases and a preparation method thereof. The cream preparation comprises active ingredients and auxiliary ingredients allowed in pharmacy; the active ingredients comprise, by weight, 3.0%-4.0% of glucosamine, 2.5%-4.0% of sodium chondroitin sulfate and 1.0%-2.5% of hyaluronic acid. The cream preparation not only can effectively prevent the joint diseases from occurring but also has the very good treatment effect on the joint diseases; the stable blood concentration can be better kept, the bioavailability is high, the administration times are decreased, and the administration dosage is accurate; in addition, the cream preparation is safer, has drug targeting, can be released to local lesion tissue at a constant speed and is significant in treatment effect, and administration can be temporarily stopped as needed if a reverse reaction occurs in the administration process.

Description

technical field [0001] The invention belongs to the technical field of pharmacy, and in particular relates to a cream for preventing and treating joint diseases and a preparation method thereof. Background technique [0002] The full name of ammonia sugar is D-glucosamine, which is a monosaccharide component and can be extracted from crab and shrimp shells. The basic component of joint fluid, industrially extracted ammonia sugar is divided into D-glucosamine hydrochloride and D-glucosamine sulfate, which are widely used in the prevention and treatment of bone and joint diseases. [0003] Glucosamine not only controls the health of human bones and joints, but also controls the metabolic balance of articular cartilage synovium. Glucosamine can stimulate and replenish a large amount of synovial fluid for the human body, thereby continuously lubricating the surface of articular cartilage, reducing wear and tear, and making joints flexible and free. Supplementing a sufficient a...

Claims

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Application Information

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IPC IPC(8): A61K31/737A61K9/06A61P19/02A61K31/7008A61K31/728
Inventor 庄小恩汪存红
Owner ZHEJIANG CANDORLY PHARMA
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