Medicine composition for functional uterine hemorrhage and postpartum hemorrhage

A technology for uterine hemorrhage and postpartum hemorrhage, applied in the direction of drug combinations, diseases, blood diseases, etc., can solve the problems of increasing patient pain, patient side effects, and poor symptomaticity, and achieve low cost, convenient medication, and wide range of drug sources Effect

Inactive Publication Date: 2015-12-30
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The traditional Chinese medicine prescription in the prior art lacks dialectics, the treatment period is long, the symptom is not strong, the curative effect is not obvious, and it may even bring side effects to the patient and increase the pain of the patient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A pharmaceutical composition for functional uterine bleeding and postpartum hemorrhage, which is prepared by the following method:

[0023] Take 1000g of broken blood flow, cut into sections, add 2 times of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, concentrate to 1.15g / ml, add 1.7 times of weight ethanol (70% here refers to volume ratio ), fully stirred, let stand for 24h, take the supernatant and concentrate it under reduced pressure to 1.1g / ml, add 1 times the weight of water, stir well, let stand for 24h, filter, add 290ml of simple syrup, 2.5g of sodium benzoate, add water to 1000ml, ready to use after stirring, filling and sterilizing.

[0024] The relative density in this paper is the relative density at 80°C.

[0025] Usage and dosage, take orally, 10ml each time, three times a day.

Embodiment 2

[0027] A pharmaceutical composition for functional uterine bleeding and postpartum hemorrhage, which is prepared by the following method:

[0028] Take 800g of broken blood, cut it into sections, add 2 times of water to decoct twice, each time for 1.5 hours, combine the decoction, filter, concentrate to 1.15g / ml, add 1.7 times of weight ethanol (70% refers to the volume ratio ), fully stirred, stood still for 24 hours, took the supernatant and concentrated it under reduced pressure to 1.1g / ml, added 1 times the weight of water, stirred fully, stood still for 24 hours, filtered, added 200ml of blood-enriching active ingredients, 240ml of simple syrup, sodium benzoate 2.5g, add water to 1000ml, stir, fill and sterilize.

[0029] The blood-enriching active ingredient is prepared from the following raw materials in parts by weight:

[0030] 20 parts of arborvitae leaves, 20 parts of Huai Mi, 20 parts of Imperata rhizome, 15 parts of large thistle, 15 parts of angelica,

[0031] ...

Embodiment 3

[0037] Drug efficacy experiment

[0038] Establishing the model: the rats were subjected to vaginal smear examination at 16:00 p.m., and they were divided into cages according to preestrus, estrus, late estrus, and interphase. The mice were caged together, and the vaginal smear was observed at 8:00 the next morning, and the sperm was found on the first day of pregnancy. On the 7th day, mifepristone (8:00) and misoprostol (18:00) were given intragastrically, and a quantitative cotton ball was inserted into the vagina at the same time (the weight of the cotton ball was 70-80mg, and half of the cotton ball was wrapped with plastic film. , to prevent blood leakage and urine reflux). The next day, the cotton balls were taken out at 8:00 and 18:00 respectively, and put into plastic bags for airtight and refrigerated storage. At the same time, a new cotton ball was replaced in the vagina, and vaginal bleeding was observed. The animals were sacrificed until the 14th day. The vaginal...

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PUM

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Abstract

The invention relates to a medicine composition for functional uterine hemorrhage and postpartum hemorrhage. A preparation method of the medicine composition comprises the following steps: taking 1000 g of clinopodium polycephalum, chopping, adding water for 1.5 hours' decocting twice, merging decoctions, filtering, concentrating to obtain a concentrate I of 1.15 g/ml, adding ethanol of which the weight is 1.7 times of that of the concentrate I, fully stirring, performing still standing for 24 h, taking an supernatant, conducting vacuum concentration to obtain a concentrate II 1.1 g/ml, adding water of which the weight is double of that of the concentrate II, fully stirring, performing still standing for 24 h, filtering, adding 290 ml of simple syrup and 2.5 g of sodium benzoate, adding water until 1000 ml, and conducting stirring, filling and sterilization to obtain the medicine composition. The prepared medicine composition is low in cost and wide in application prospect.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to a pharmaceutical composition for functional uterine hemorrhage and postpartum hemorrhage. Background technique [0002] Dysfunctional uterine bleeding, also known as uterine blood, is caused by neuroendocrine disorders, not by pregnancy, endometrial tumors, infections or blood diseases. It often occurs in puberty, all of which are anovulatory dysfunctional uterine bleeding, also known as adolescent dysfunctional uterine bleeding. The cause of anovulatory DUB is different in adolescence and menopause. Adolescent DUB is mostly due to the hypothalamus-pituitary-ovarian axis. Under the influence of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the pituitary gland, the follicle develops and secretes estrogen, but estrogen has no effect on The positive feedback of the hypothalamus should not yet form the peak of FSH and LH in th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9064A61P15/00A61P7/04
Inventor 林凡儒林凡友聂昌盛付君叶杜玲杰
Owner XIANGYU PHARMA
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