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A kind of packing of sodium bicarbonate injection

A sodium bicarbonate and injection technology, applied in the field of pharmaceutical packaging, can solve the problems of sodium bicarbonate injection pH value exceeding the limit, short storage period, etc., and achieve the effects of improving long-term storage stability, preventing loss, and improving drug safety

Active Publication Date: 2018-05-01
SICHUAN KELUN PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the above problems, the purpose of this invention is to provide a kind of packaging of sodium bicarbonate injection, to solve the infusion bag packaging of sodium bicarbonate injection along with the prolongation of time, the pH value of sodium bicarbonate injection exceeds the limit, storage period Short, safety issues caused by adding stabilizers

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033]A kind of packaging of sodium bicarbonate injection, comprising the multi-layer co-extrusion infusion bag for containing sodium bicarbonate injection as an inner bag, a first barrier outer bag, a second barrier outer bag, and the inner bag is arranged outside the second barrier In the bag, the second barrier outer bag is set in the first barrier outer bag, and the inner bag is filled with a mixed gas composed of carbon dioxide gas and nitrogen gas. The volume ratio of carbon dioxide gas and nitrogen gas in the mixed gas is 1:1. The inner bag The volume percentage of the mixed gas filled between the second barrier outer bag and the second barrier outer bag is 70%, and the inner bag and the second barrier outer bag are filled with a mixed gas composed of carbon dioxide and nitrogen. The volume of carbon dioxide gas and nitrogen in the mixed gas The ratio is 1:1, the volume percentage of the mixed gas is 50%, nitrogen is filled between the second gas-barrier outer bag and th...

Embodiment 2

[0040] A kind of packaging of sodium bicarbonate injection, comprising the multi-layer co-extrusion infusion bag for containing sodium bicarbonate injection as an inner bag, a first barrier outer bag, a second barrier outer bag, and the inner bag is arranged outside the second barrier In the bag, the second barrier outer bag is set in the first barrier outer bag, and the inner bag is filled with a mixed gas composed of carbon dioxide gas and nitrogen gas. The volume ratio of carbon dioxide gas and nitrogen gas in the mixed gas is 3:1. The inner bag The volume percentage of the mixed gas filled between the second barrier outer bag and the second barrier outer bag is 80%, and the inner bag and the second barrier outer bag are filled with a mixed gas composed of carbon dioxide and nitrogen. The volume of carbon dioxide gas and nitrogen in the mixed gas The ratio is 3:1, the volume percentage of the mixed gas is 60%, nitrogen is filled between the second gas-barrier outer bag and t...

Embodiment 3

[0047] A kind of packaging of sodium bicarbonate injection, comprising the multi-layer co-extrusion infusion bag for containing sodium bicarbonate injection as an inner bag, a first barrier outer bag, a second barrier outer bag, and the inner bag is arranged outside the second barrier In the bag, the second barrier outer bag is set in the first barrier outer bag, and the inner bag is filled with a mixed gas composed of carbon dioxide gas and nitrogen gas. The volume ratio of carbon dioxide gas and nitrogen gas in the mixed gas is 2:1. The inner bag The volume percentage of the mixed gas filled between the second barrier outer bag and the second barrier outer bag is 90%, and the mixed gas composed of carbon dioxide and nitrogen is filled between the inner bag and the second barrier outer bag. The volume of carbon dioxide gas and nitrogen in the mixed gas The ratio is 2:1, the volume percentage of the mixed gas is 75%, nitrogen is filled between the second gas barrier outer bag a...

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Abstract

The invention discloses a package for sodium bicarbonate injection. The package comprises an infusion bag used for containing sodium bicarbonate injection serving as an inner bag, a first outer separation bag and a second outer separation bag. The inner bag is arranged in the second outer separation bag which is arranged in the first outer separation bag. The interior of the inner bag is filled up with mixed gas. The volume ratio of carbon dioxide gas and nitrogen gas in mixed gas ranges from 1:1 to 3:1. Mixed gas is filled between the inner bag and the second outer separation bag. The volume ratio of carbon dioxide gas and nitrogen gas in mixed gas ranges from 1:1 to 3:1. Nitrogen gas is filled between a second outer gas-resisting bag and a first outer gas-resisting bag.The package for sodium bicarbonate injection has following beneficial effects: mixed gas composed of carbon dioxide and nitrogen gas is filled into the infusion bag and can completely replace a stabilizer of injection in order to avoid side effect of the stabilizer; the packaging structure can effectively overcome a decomposition problem of sodium bicarbonate injection in order to avoid green house effect; and stability of long-term storage for injection and medication safety of a patient are improved.

Description

technical field [0001] The invention relates to medicine packaging, in particular to a new packaging structure for sodium bicarbonate injection. Background technique [0002] As a clinical emergency drug, sodium bicarbonate injection is mainly used in the following clinical applications: (1) Treatment of metabolic acidosis: for mild to moderate metabolic acidosis, oral administration is appropriate. Severe metabolic acidosis should be administered intravenously, such as severe kidney disease, circulatory failure, cardiopulmonary resuscitation, extracorporeal circulation, severe primary lactic acidosis, diabetic ketoacidosis, etc. (2) Alkalinizing urine: It is used to prevent uric acid kidney stones, reduce the nephrotoxicity of sulfonamide and other drugs, and prevent hemoglobin from depositing in renal tubules during acute hemolysis. (3) As an antacid, treat symptoms caused by hyperacidity. (4) Intravenous infusion has a non-specific therapeutic effect on certain drug poi...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61J1/10A61K33/00A61K9/08
Inventor 朱麟谭鸿波刘文军雷祥杰罗帅邓茂林吴小愚何颖
Owner SICHUAN KELUN PHARMA CO LTD
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