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Temperature-control detachable bath for configuration of field stimulating electrode and application method thereof

A technology for stimulating electrodes and baths, which is applied in the field of temperature-controlled detachable baths, can solve problems such as experimental interference, affecting the stability and reliability of results, and occupying space, so as to ensure experimental results, be suitable for popularization and use, and improve experimental efficiency. Effect

Inactive Publication Date: 2016-01-27
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This experimental device has the following defects: 1. The structure of the external electrode is thick (L-shaped fixed bracket is required). After entering the small-capacity bath from above the bath, there is a serious space occupation phenomenon, which is necessary for subsequent experimental operations such as replacing new tissues or Observation of organs and dosing will increase the difficulty, which will easily cause interference to the experiment and affect the stability and reliability of the results; 2. The external electrodes need to be fixed separately, and the relative position with the isolated tissues and organs is easy to change, and needs to be adjusted frequently. It affects the stability of the results, prolongs the preparation time of the experiment, and reduces the use efficiency of the tested specimens; 3. The electrode is easy to be damaged when replacing the tissue in the narrow bath; if the bath with a larger space is replaced, the overall bath volume will inevitably increase, and the The results become unreliable when it is necessary to observe the effect of trace amounts of the drug
[0004] The article "Application of Trace Multiconductor Horizontal Bath in the Research of Integrative Traditional Chinese and Western Medicine" (Wei Muxin, Department of Traditional Chinese Medicine, The First Affiliated Hospital of Nanjing Medical University) discloses a horizontal bath to solve the inconvenience caused by external electrodes, but most laboratories currently use it Vertical bath, replacement of horizontal bath will result in waste and high cost of vertical bath
Based on the above-mentioned problems in the electric field stimulation experiment of isolated tissues or organs, in general experimental education, only the simple observation of the aforementioned active contraction activities can be carried out, and it cannot be involved in the research and study of the electric field stimulation project, which brings great benefits to the comprehensive experiment and study. hinder

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  • Temperature-control detachable bath for configuration of field stimulating electrode and application method thereof
  • Temperature-control detachable bath for configuration of field stimulating electrode and application method thereof
  • Temperature-control detachable bath for configuration of field stimulating electrode and application method thereof

Examples

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Embodiment 1

[0037] A detachable temperature-controlled bath equipped with field stimulating electrodes, comprising a full water jacket 4 and a bath, the bath is detachably arranged in the full water jacket 4; the full water jacket 4 is provided with a temperature-controlled perfusion inlet 6 and a temperature control perfusion outlet 7; the bath is provided with an electrode group and an oxygen inlet 9; the electrode group includes a positive electrode 1 and a negative electrode 2; the positive electrode 1 and the negative electrode 2 are arranged vertically; The electrode and the negative electrode are made of stainless steel (or other materials such as depolarized silver wire or platinum wire). The full water jacket 4 is set separately from the bath tank, and the bath tank can be separated from the full water jacket 4 according to the needs of the experiment, and then placed separately in any temperature environment required by the experiment for testing.

Embodiment 2

[0039] The detachable temperature-controlled bath equipped with field stimulation electrodes as described in Example 1 differs in that the electrode groups include multiple pairs of positive electrodes 1 and negative electrodes 2; each electrode group is connected to a separate control switch. The advantage of the design here is that it adapts to the specifications of tissue or organ samples from different sources, ensures that the samples can be stimulated by an effective electric field, improves the accuracy and diversification of the experiment, and has higher versatility.

Embodiment 3

[0041]The detachable temperature-controlled bath configured with field stimulating electrodes as described in Example 2 is different in that an electrode joint 14 is provided through the side wall of the bath, and the positive electrode 1 and the negative electrode 2 are connected to the electrode joint respectively. Hinged; the electrode joint 14 is electrically connected to the stimulator 10 . The electrodes are hinged with the electrode connector 14. After the positive and negative electrodes are selected according to the experimental requirements, the electrodes that do not need to be opened can be folded up to be flush with the inner wall of the bath, so as to avoid interference with the experimental operation, improve the experimental efficiency, and facilitate observation. .

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Abstract

The invention relates to a detachable temperature-control bath for configuration of a field stimulating electrode and an application method thereof. The bath comprises a full water jacket and a bath. The full water jacket is provided with a temperature-control perfusion inlet and a temperature-control perfusion outlet. An electrode assembly and an oxygen inlet are arranged in the bath. The electrode assembly comprises a positive electrode and a negative electrode which are arranged opposite to each other in the vertical direction. The full water jacket and the bath are separately arranged and can be individually placed in any temperature environment required by experiments for testing after separated from each other according to experiment needs. The detachable temperature-control bath for configuration of the field stimulating electrode has advantages of compact and concise design, low cost and no higher requirement on electrode material, is suitable for popularization and application, is easy to dismount and replace and is compatible with experiment requirements on different capacities and temperature demands.

Description

Technical field: [0001] The invention relates to a temperature-controlled detachable bath equipped with field stimulating electrodes and a method for using the same, belonging to the technical field of isolated tissue or organ experiments. Background technique: [0002] In modern medicine, biology, especially neuroscience research, muscle tension analysis of isolated tissues or organs is one of the most important and widely used experimental techniques. It provides functional research evidence at the organ tissue level for the research of physiology, pharmacology and other disciplines, and can be combined with other studies from the molecular cell level and the whole animal level to achieve high-level and comprehensive research. The study of neuromodulation is an important topic in the study of the functional activities of isolated tissues or organs; this study requires that in addition to the observation of active contraction tension (that is, only a certain mechanical prel...

Claims

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Application Information

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IPC IPC(8): G01N27/00
Inventor 王蓉刘传勇
Owner SHANDONG UNIV