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Application of 3-phenylcoumarin robustic acid

A technology of licorice root and pharmaceutical preparation, applied in the field of medicine, can solve the problems of high oxidative stress, reduced oxygen free radical scavenging ability of free radicals, etc., and achieve the effect of strong inhibitory activity

Active Publication Date: 2016-02-03
南城县工业与科技创新投资发展集团有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the oxidative stress in diabetic patients is higher than that of normal people. Oxidative stress is caused by the oxidation of sugar and the reaction between sugar and protein. This process increases oxygen free radicals and reduces the ability to scavenge free radicals.

Method used

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  • Application of 3-phenylcoumarin robustic acid
  • Application of 3-phenylcoumarin robustic acid
  • Application of 3-phenylcoumarin robustic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Mix soil licorice A and starch slurry at a mass ratio of 1:1, pass through a 80-mesh sieve, mix well, add 10% starch slurry, pass through a 14-mesh sieve to granulate, and dry at 52°C until the moisture content is lower than 1%. The dry granules are granulated through a 16-mesh sieve. The prepared dry granule is added with 3% magnesium stearate, mixed evenly, and pressed into tablets, and the weight of each tablet is controlled to be 0.2 g, so as to obtain the tablet of Glycyrrhizae A.

Embodiment 2

[0029] Dry the soil licorice A into powder, mix the soil licorice A and starch in a mass ratio of 2:1, add 0.5% magnesium stearate in total weight, fill it with hard capsules, control the filling amount at 0.2-0.3g, That is to get the capsule of licorice A.

Embodiment 3

[0031] Mix soil licorice A and sodium chloride at a mass ratio of 60:40, dissolve in water for injection, filter to obtain a solution, and fill it into an ampoule under aseptic conditions to obtain an injection.

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Abstract

The invention discloses an application of 3-phenylcoumarin robustic acid in a medicinal preparation for treating diabetes. Free radical removing experiments in vitro prove that the 3-phenylcoumarin robustic acid has obvious removing effects on DPPH free radicals and ABTS free radicals, and IC50 values are 1mg / ml and 0.5mg / ml respectively; the 3-phenylcoumarin robustic acid and 2,6-di-tert-butyl-4-methylphenol have similar antioxidation capabilities. At the same time, the 3-phenylcoumarin robustic acid has a good inhibition effect on alpha-glucosidase activity.

Description

technical field [0001] The invention relates to the technical field of medicine. More specifically, the present invention relates to an application of licorice root A. Background technique [0002] Diabetes is a metabolic disorder of sugar, protein and fat. Its etiology and pathogenesis have not been fully elucidated, mainly due to abnormal secretion or production of insulin. Clinically, it is manifested as polydipsia, polyuria, polyphagia, weight loss, etc . Studies have shown that inhibitors of α-glucosidase can inhibit the activity of α-glucosidase in the upper part of the small intestine, and can block the decomposition of carbohydrates into single glucose, so as to achieve the purpose of controlling excessive blood sugar after meals. In addition, the oxidative stress in diabetic patients is higher than that of normal people. Oxidative stress is caused by the oxidation of sugar and the reaction of sugar and protein. This process increases oxygen free radicals and reduc...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/37A61P3/10A61P39/06
Inventor 霍丽妮韦建华陈睿李培源苏炜
Owner 南城县工业与科技创新投资发展集团有限公司
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